Discovery of N‑(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)‑3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model
Fales, Kevin R., Njoroge, F. George, Brooks, Harold B., Thibodeaux, Stefan, Torrado, Alicia, Si, Chong, Toth, James L., Mc Cowan, Jefferson R., Roth, Kenneth D., Thrasher, Kenneth J., Frimpong, Kwame, Lee, Matthew R., Dally, Robert D., Shepherd, Timothy A., Durham, Timothy B., Margolis, Brandon J., Wu, Zhipei, Wang, Yong, Atwell, Shane, Wang, Jing, Hui, Yu-Hua, Meier, Timothy I., Konicek, Susan A., Geeganage, Sandaruwan
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models
Brooks, Harold B, Meier, Timothy I, Geeganage, Sandaruwan, Fales, Kevin R, Thrasher, Kenneth J, Konicek, Susan A, Spencer, Charles D, Thibodeaux, Stefan, Foreman, Robert T, Hui, Yu-Hua, Roth, Kenneth D, Qian, Yue-Wei, Wang, Tao, Luo, Shuang, Torrado, Alicia, Si, Chong, Toth, James L, Mc Cowan, Jefferson R, Frimpong, Kwame, Lee, Matthew R, Dally, Robert D, Shepherd, Timothy A, Durham, Timothy B, Wang, Yong, Wu, Zhipei, Iversen, Philip W, Njoroge, F George
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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Utilizing 19F NMR to investigate drug disposition early in drug discovery
Hu, Haitao, Huang, Naijia, Yi, Ping, Hui, Yu-Hua, Dally, Robert D., Ehlhardt, William J., Kulanthaivel, Palaniappan
Published in Xenobiotica (2015)
Published in Xenobiotica (2015)
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A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats
Hummel, Conrad W, Geiser, Andrew G, Bryant, Henry U, Cohen, Ilene R, Dally, Robert D, Fong, Kin Chiu, Frank, Scott A, Hinklin, Ronald, Jones, Scott A, Lewis, George, McCann, Denis J, Rudmann, Daniel G, Shepherd, Timothy A, Tian, Hongqi, Wallace, Owen B, Wang, Minmin, Wang, Yong, Dodge, Jeffrey A
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Structure–activity relationships of SERMs optimized for uterine antagonism and ovarian safety
Richardson, Timothy I., Frank, Scott A., Wang, Minmin, Clarke, Christian A., Jones, Scott A., Ying, Bai-Ping, Kohlman, Dan T., Wallace, Owen B., Shepherd, Timothy A., Dally, Robert D., Palkowitz, Alan D., Geiser, Andrew G., Bryant, Henry U., Henck, Judith W., Cohen, Ilene R., Rudmann, Daniel G., McCann, Denis J., Coutant, David E., Oldham, Samuel W., Hummel, Conrad W., Fong, Kin C., Hinklin, Ronald, Lewis, George, Tian, Hongqi, Dodge, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Utilizing 19 F NMR to investigate drug disposition early in drug discovery
Hu, Haitao, Huang, Naijia, Yi, Ping, Hui, Yu-Hua, Dally, Robert D., Ehlhardt, William J., Kulanthaivel, Palaniappan
Published in Xenobiotica (02.12.2015)
Published in Xenobiotica (02.12.2015)
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O1-06-02: The design and synthesis of an efficacious BACE inhibitor
McCarthy, James R., Agejas, Javier, Bender, David M., Broughton, Howard, Bueno, Ana, Dally, Robert D., Durham, Timothy, Erickson, Jon A., Espinosa, Juan F., Gonzalez, Rosario, Hahn, Patric J., Laigle, Debra K., Kohn, Todd J., May, Patrick C., Rodriguez, Juan R., Sanz, Gema, Shepherd, Timothy A., Timm, David, Vidal, Paloma, Yang, Hsiu-Chiung
Published in Alzheimer's & dementia (01.07.2006)
Published in Alzheimer's & dementia (01.07.2006)
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PYRROLIDINE DERIVATIVES USEFUL AS BASE INHIBITORS
BENDER DAVID M, SHEPHERD TIMOTHY A, ROJO GARCIA MARIA I, DALLY ROBERT D
Year of Publication 13.09.2007
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Year of Publication 13.09.2007
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Selective estrogen receptor modulators
WEBER WAYNE W.II, DODGE JEFFREY A, SHEPHERD TIMOTHY A, HUMMEL CONRAD W, WALLACE OWEN B, JONES SCOTT A, DALLY ROBERT D
Year of Publication 17.05.2007
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Year of Publication 17.05.2007
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Selective estrogen receptor modulators containing a phenylsulfonyl group
DODGE JEFFREY A, LEWIS GEORGE S, SHEPHERD TIMOTHY A, HUMMEL CONRAD W, FRANK SCOTT A, WALLACE OWEN B, JONES SCOTT A, DALLY ROBERT D, FONG KIN C
Year of Publication 17.08.2006
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Year of Publication 17.08.2006
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3-(2-Acylamino-1-Hydroxyethyl)-Morpholine Derivatives and Their Use as Bace Inhibitors
MCCARTHY JAMES R, BUENO MELENDO ANA B, SHEPHERD TIMOTHY A, HENRY KENNETH J.JR, KOHN TODD J, SA LILLY, GONZALEZ-GARCIA MARIA ROSARIO, HAHN PATRIC J, DALLY ROBERT D, DURHAM TIMOTHY B, BROUGHTON HOWARD B, ERICKSON JON A
Year of Publication 27.09.2007
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Year of Publication 27.09.2007
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Sulfonamidaminomethylenderivater som immunosuppressive stoffer
CONNELL, RICHARD D, DALLY, ROBERT D, KATZ, MICHAEL E, OSTERMAN, DAVID G
Year of Publication 19.07.1999
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Year of Publication 19.07.1999
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SULFONAMIDAMINOMETHYLENDERIVATE ALS IMMUNSUPPRESSIVA
CONNELL, RICHARD D, DALLY, ROBERT D, KATZ, MICHAEL E, OSTERMAN, DAVID G
Year of Publication 15.11.1998
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Year of Publication 15.11.1998
Patent
Sulfonamide aminomethylene derivatives as immunosuppressants
CONNELL, RICHARD D, DALLY, ROBERT D, KATZ, MICHAEL E, OSTERMAN, DAVID G
Year of Publication 04.11.1998
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Year of Publication 04.11.1998
Patent
Aminomethylene derivaties as immunosuppressants
OSTERMAN; DAVID G, CONNELL; RICHARD D, KATZ; MICHAEL E, DALLY; ROBERT D
Year of Publication 11.11.1997
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Year of Publication 11.11.1997
Patent
Sulfonamide aminomethylene derivatives as immunosuppressants
OSTERMAN; DAVID G, CONNELL; RICHARD D, KATZ; MICHAEL E, DALLY; ROBERT D
Year of Publication 27.05.1997
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Year of Publication 27.05.1997
Patent
Benzimidazoles and benzothiazoles as inhibitors of map kinase
PLEITE SELGAS SHEILA, DE DIOS ALFONSO, BONJOUKLIAN ROSANNE, VIETH MICHAL, DALLY ROBERT D, MARTIN-CABREJAS LUISA M, SANCHEZ-MARTINEZ CONCEPCION, LI TIECHO, YORK JEREMY S, SHEPHERD TIMOTHY A, HAMDOUCHI CHAFIQ H, WIKEL JAMES H, MONTERO SALGADO CARLOS, DE URALDE GARMENDIA BEATRIZ L, DEL PRADO CATALINA MIRIAM F, JARAMILLO AGUADO CARLOS, DE DIEGO GOMEZ JOSE E
Year of Publication 08.12.2005
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Year of Publication 08.12.2005
Patent
NOVEL AMINOMETHYLENE DERIVATIVES AS IMMUNOSUPPRESSANTS
CONNELL, RICHARD D, DALLY, ROBERT D, KATZ, MICHAEL E, OSTERMAN, DAVID G
Year of Publication 28.09.1994
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Year of Publication 28.09.1994
Patent