Discovery of N‑(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)‑3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model
Fales, Kevin R., Njoroge, F. George, Brooks, Harold B., Thibodeaux, Stefan, Torrado, Alicia, Si, Chong, Toth, James L., Mc Cowan, Jefferson R., Roth, Kenneth D., Thrasher, Kenneth J., Frimpong, Kwame, Lee, Matthew R., Dally, Robert D., Shepherd, Timothy A., Durham, Timothy B., Margolis, Brandon J., Wu, Zhipei, Wang, Yong, Atwell, Shane, Wang, Jing, Hui, Yu-Hua, Meier, Timothy I., Konicek, Susan A., Geeganage, Sandaruwan
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models
Brooks, Harold B, Meier, Timothy I, Geeganage, Sandaruwan, Fales, Kevin R, Thrasher, Kenneth J, Konicek, Susan A, Spencer, Charles D, Thibodeaux, Stefan, Foreman, Robert T, Hui, Yu-Hua, Roth, Kenneth D, Qian, Yue-Wei, Wang, Tao, Luo, Shuang, Torrado, Alicia, Si, Chong, Toth, James L, Mc Cowan, Jefferson R, Frimpong, Kwame, Lee, Matthew R, Dally, Robert D, Shepherd, Timothy A, Durham, Timothy B, Wang, Yong, Wu, Zhipei, Iversen, Philip W, Njoroge, F George
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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Utilizing 19F NMR to investigate drug disposition early in drug discovery
Hu, Haitao, Huang, Naijia, Yi, Ping, Hui, Yu-Hua, Dally, Robert D., Ehlhardt, William J., Kulanthaivel, Palaniappan
Published in Xenobiotica (2015)
Published in Xenobiotica (2015)
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A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats
Hummel, Conrad W, Geiser, Andrew G, Bryant, Henry U, Cohen, Ilene R, Dally, Robert D, Fong, Kin Chiu, Frank, Scott A, Hinklin, Ronald, Jones, Scott A, Lewis, George, McCann, Denis J, Rudmann, Daniel G, Shepherd, Timothy A, Tian, Hongqi, Wallace, Owen B, Wang, Minmin, Wang, Yong, Dodge, Jeffrey A
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach
Smith, Roger A, Barbosa, James, Blum, Cheri L, Bobko, Mark A, Caringal, Yolanda V, Dally, Robert, Johnson, Jeffrey S, Katz, Michael E, Kennure, Nancy, Kingery-Wood, Jill, Lee, Wendy, Lowinger, Timothy B, Lyons, John, Marsh, Vivienne, Rogers, Daniel H, Swartz, Stephen, Walling, Tracy, Wild, Hanno
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Structure–activity relationships of SERMs optimized for uterine antagonism and ovarian safety
Richardson, Timothy I., Frank, Scott A., Wang, Minmin, Clarke, Christian A., Jones, Scott A., Ying, Bai-Ping, Kohlman, Dan T., Wallace, Owen B., Shepherd, Timothy A., Dally, Robert D., Palkowitz, Alan D., Geiser, Andrew G., Bryant, Henry U., Henck, Judith W., Cohen, Ilene R., Rudmann, Daniel G., McCann, Denis J., Coutant, David E., Oldham, Samuel W., Hummel, Conrad W., Fong, Kin C., Hinklin, Ronald, Lewis, George, Tian, Hongqi, Dodge, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Synthesis of optically active 6-substituted 2-(aminomethyl)chromans
Zhang, Mingbao, Reeves, Raymond, Bi, Cheng, Dally, Robert, Ladouceur, Gaetan, Bullock, William, Chin, Jefferson
Published in Tetrahedron letters (28.06.2004)
Published in Tetrahedron letters (28.06.2004)
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Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences
Bueno, Ana B., Agejas, Javier, Broughton, Howard, Dally, Robert, Durham, Timothy B., Espinosa, Juan Félix, González, Rosario, Hahn, Patric J., Marcos, Alicia, Rodríguez, Ramón, Sanz, Gema, Soriano, José F., Timm, David, Vidal, Paloma, Yang, Hsiu-Chiung, McCarthy, James R.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Utilizing 19 F NMR to investigate drug disposition early in drug discovery
Hu, Haitao, Huang, Naijia, Yi, Ping, Hui, Yu-Hua, Dally, Robert D., Ehlhardt, William J., Kulanthaivel, Palaniappan
Published in Xenobiotica (02.12.2015)
Published in Xenobiotica (02.12.2015)
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Imidazolyl benzimidazoles and imidazo[4,5- b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties
Mader, Mary, de Dios, Alfonso, Shih, Chuan, Bonjouklian, Rosanne, Li, Tiechao, White, Wesley, de Uralde, Beatriz López, Sánchez-Martinez, Concepción, del Prado, Miriam, Jaramillo, Carlos, de Diego, Eugenio, Martín Cabrejas, Luisa M., Dominguez, Carmen, Montero, Carlos, Shepherd, Timothy, Dally, Robert, Toth, John E., Chatterjee, Arindam, Pleite, Sehila, Blanco-Urgoiti, Jaime, Perez, Leticia, Barberis, Mario, Lorite, María José, Jambrina, Enrique, Nevill, C. Richard, Lee, Paul A., Schultz, Richard C., Wolos, Jeffrey A., Li, Li C., Campbell, Robert M., Anderson, Bryan D.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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CD73 억제제
NJOROGE FRANK GEORGE, GARCIA PAREDES MARIA CRISTINA, HOWELL JENNIFER MARIE, ZHAO GENSHI, DALLY ROBERT DEAN, HEINZ LAWRENCE JOSEPH II, WANG YAN
Year of Publication 13.10.2020
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Year of Publication 13.10.2020
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