MP14: Community paramedic point of care blood analysis: validity and usability testing of two commercially available devices
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Structural basis for the binding of proline-rich peptides to SH3 domains
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Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers
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Src inhibitors: genomics to therapeutics
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Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption
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Structure of the PI3K SH3 domain and analysis of the SH3 family
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X-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 Inhibitor
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Structure-based design and synthesis of a novel class of Src SH2 inhibitors
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Published in Bioorganic & medicinal chemistry letters (16.08.1999)
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Structure-Based Design of Novel Bicyclic Nonpeptide Inhibitors for the Src SH2 Domain
Shakespeare, William C, Bohacek, Regine S, Azimioara, Mihai D, Macek, Karina J, Luke, George P, Dalgarno, David C, Hatada, Marcos H, Lu, Xiaode, Violette, Shelia M, Bartlett, Catherine, Sawyer, Tomi K
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Protein phosphorylation and signal transduction modulation: chemistry perspectives for small-molecule drug discovery
Sawyer, T K, Shakespeare, W C, Wang, Y, Sundaramoorthi, R, Huang, W-S, Metcalf, 3rd, C A, Thomas, M, Lawrence, B M, Rozamus, L, Noehre, J, Zhu, X, Narula, S, Bohacek, R S, Weigele, M, Dalgarno, D C
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Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.05.2005)
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Preclinical characterization of CNS-active, mutant-selective fourth-generation EGFR inhibitors with potent activity against single, double, and triple mutant EGFR variants including T790M and C797S
Zhang, S., Huang, W.S., Nadworny, S., Ye, E., Narasimhan, N., Eyermann, C.J., Dalgarno, D., Rivera, V., Shakespeare, W.
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AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim
Published in Cancer cell (06.11.2009)
Published in Cancer cell (06.11.2009)
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An efficient synthesis of a 4′-phosphonodifluoromethyl-3′-formyl-phenylalanine containing Src SH2 ligand
Shakespeare, William C., Bohacek, Regine S., Narula, Surinder S., Azimioara, Mihai D., Yuan, Ruth W., Dalgarno, David C., Madden, Laura, Botfield, Martyn C., Holt, Dennis A.
Published in Bioorganic & medicinal chemistry letters (01.11.1999)
Published in Bioorganic & medicinal chemistry letters (01.11.1999)
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A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain
Kawahata, N, Yang, M G, Luke, G P, Shakespeare, W C, Sundaramoorthi, R, Wang, Y, Johnson, D, Merry, T, Violette, S, Guan, W, Bartlett, C, Smith, J, Hatada, M, Lu, X, Dalgarno, D C, Eyermann, C J, Bohacek, R S, Sawyer, T K
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML
O'Hare, Thomas, Pollock, Roy, Stoffregen, Eric P., Keats, Jeffrey A., Abdullah, Omar M., Moseson, Erika M., Rivera, Victor M., Tang, Hao, Metcalf, Chester A., Bohacek, Regine S., Wang, Yihan, Sundaramoorthi, Raji, Shakespeare, William C., Dalgarno, David, Clackson, Tim, Sawyer, Tomi K., Deininger, Michael W., Druker, Brian J.
Published in Blood (15.10.2004)
Published in Blood (15.10.2004)
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A point mutation of human interferon gamma abolishes receptor recognition
Lunn, C A, Fossetta, J, Dalgarno, D, Murgolo, N, Windsor, W, Zavodny, P J, Narula, S K, Lundell, D
Published in Protein engineering (01.04.1992)
Published in Protein engineering (01.04.1992)
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An active covalently linked dimer of human interferon-gamma. Subunit orientation in the native protein
LUNN, C. A, DAVIES, L, DALGARNO, D, NARULA, S. K, ZAVODNY, P. J, LUNDELL, D
Published in The Journal of biological chemistry (05.09.1992)
Published in The Journal of biological chemistry (05.09.1992)
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