First X-ray Cocrystal Structure of a Bacterial FabH Condensing Enzyme and a Small Molecule Inhibitor Achieved Using Rational Design and Homology Modeling
Daines, Robert A, Pendrak, Israil, Sham, Kelvin, Van Aller, Glenn S, Konstantinidis, Alex K, Lonsdale, John T, Janson, Cheryl A, Qiu, Xiayang, Brandt, Martin, Khandekar, Sanjay S, Silverman, Carol, Head, Martha S
Published in Journal of medicinal chemistry (02.01.2003)
Published in Journal of medicinal chemistry (02.01.2003)
Get full text
Journal Article
Crystal structure and substrate specificity of the β‐ketoacyl‐acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Qiu, Xiayang, Choudhry, Anthony E., Janson, Cheryl A., Grooms, Michael, Daines, Robert A., Lonsdale, John T., Khandekar, Sanjay S.
Published in Protein science (01.08.2005)
Published in Protein science (01.08.2005)
Get full text
Journal Article
(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists
Daines, Robert A, Chambers, Pamela A, Eggleston, Drake S, Foley, James J, Griswold, Don E, Haltiwanger, R. Curtis, Jakas, Dalia R, Kingsbury, William D, Martin, Lenox D
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
Get full text
Journal Article
Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist
Aiyar, N, Daines, R A, Disa, J, Chambers, P A, Sauermelch, C F, Quiniou, M, Khandoudi, N, Gout, B, Douglas, S A, Willette, R N
Published in The Journal of pharmacology and experimental therapeutics (01.03.2001)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.03.2001)
Journal Article
(E)-3-[6-[[(2,6-Dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2- propenoic Acid: A High-Affinity Leukotriene B4 Receptor Antagonist with Oral Antiinflammatory Activity
Daines, Robert A, Chambers, Pamela A, Foley, James J, Griswold, Don E, Kingsbury, William D, Martin, Lenox D, Schmidt, Dulcie B, Sham, Kelvin K. C, Sarau, Henry M
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
Get full text
Journal Article
Synthesis of structural analogs of leukotriene B4 and their receptor binding activity
Kingsbury, William D, Pendrak, Israil, Leber, Jack D, Boehm, Jeffery C, Mallet, Brenda, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Daines, Robert A
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
Get full text
Journal Article
Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships
Daines, Robert A, Chambers, Pamela A, Pendrak, Israil, Jakas, Dalia R, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Kingsbury, William D
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
Get full text
Journal Article
(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist
Daines, Robert A, Chambers, Pamela A, Pendrak, Israil, Jakas, Dalia R, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Griswold, Don E, Martin, Lenox D
Published in Journal of medicinal chemistry (01.09.1993)
Published in Journal of medicinal chemistry (01.09.1993)
Get full text
Journal Article
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
Khandekar, S S, Gentry, D R, Van Aller, G S, Warren, P, Xiang, H, Silverman, C, Doyle, M L, Chambers, P A, Konstantinidis, A K, Brandt, M, Daines, R A, Lonsdale, J T
Published in The Journal of biological chemistry (10.08.2001)
Published in The Journal of biological chemistry (10.08.2001)
Get full text
Journal Article
Identification, Substrate Specificity, and Inhibition of theStreptococcus pneumoniae β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH)
Khandekar, Sanjay S., Gentry, Daniel R., Van Aller, Glenn S., Warren, Patrick, Xiang, Hong, Silverman, Carol, Doyle, Michael L., Chambers, Pamela A., Konstantinidis, Alex K., Brandt, Martin, Daines, Robert A., Lonsdale, John T.
Published in The Journal of biological chemistry (10.08.2001)
Published in The Journal of biological chemistry (10.08.2001)
Get full text
Journal Article
Identification, Substrate Specificity, and Inhibition of theStreptococcus pneumoniae β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH)
Sanjay S. Khandekar, Daniel R. Gentry, Glenn S. Van Aller, Patrick Warren, Hong Xiang, Carol Silverman, Michael L. Doyle, Pamela A. Chambers, Alex K. Konstantinidis, Martin Brandt, Robert A. Daines, John T. Lonsdale
Published in The Journal of biological chemistry (10.08.2001)
Published in The Journal of biological chemistry (10.08.2001)
Get full text
Journal Article
Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists
Daines, Robert A., Sham, Kelvin K.C., Taggart, Jack J., Kingsbury, William D., Chan, James, Breen, Ann, Disa, Jyoti, Aiyar, Nambi
Published in Bioorganic & medicinal chemistry letters (21.10.1997)
Published in Bioorganic & medicinal chemistry letters (21.10.1997)
Get full text
Journal Article