Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor
Al-Karmalawy, Ahmed A., Dahab, Mohammed A., Metwaly, Ahmed M., Elhady, Sameh S., Elkaeed, Eslam B., Eissa, Ibrahim H., Darwish, Khaled M.
Published in Frontiers in chemistry (04.05.2021)
Published in Frontiers in chemistry (04.05.2021)
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New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies
Elkady, Hazem, Elwan, Alaa, El-Mahdy, Hesham A., Doghish, Ahmed S., Ismail, Ahmed, Taghour, Mohammed S., Elkaeed, Eslam B., Eissa, Ibrahim H., Dahab, Mohammed A., Mahdy, Hazem A., Khalifa, Mohamed M.
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
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New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
Elkaeed, Eslam B., Taghour, Mohammed S., Mahdy, Hazem A., Eldehna, Wagdy M., El-Deeb, Nehal M., Kenawy, Ahmed M., A. Alsfouk, Bshra, Dahab, Mohammed A., Metwaly, Ahmed M., Eissa, Ibrahim H., El-Zahabi, Mohamed A.
Published in Journal of enzyme inhibition and medicinal chemistry (31.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (31.12.2022)
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Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation
Elwan, Alaa, Abdallah, Abdallah E, Mahdy, Hazem A, Dahab, Mohammed A, Taghour, Mohammed S, Elkaeed, Eslam B, Mehany, Ahmed B M, Nabeeh, Ahmed, Adel, Mohammed, Alsfouk, Aisha A, Elkady, Hazem, Eissa, Ibrahim H
Published in Molecules (Basel, Switzerland) (08.08.2022)
Published in Molecules (Basel, Switzerland) (08.08.2022)
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Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation
Taghour, Mohammed S., Mahdy, Hazem A., Gomaa, Maher H., Aglan, Ahmed, Eldeib, Mahmoud Gomaa, Elwan, Alaa, Dahab, Mohammed A., Elkaeed, Eslam B., Alsfouk, Aisha A., Khalifa, Mohamed M., Eissa, Ibrahim H., Elkady, Hazem
Published in Journal of enzyme inhibition and medicinal chemistry (31.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (31.12.2022)
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Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
Sobh, Eman A., Dahab, Mohammed A., Elkaeed, Eslam B., Alsfouk, Aisha A., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
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Journal Article
Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers
Eissa, Ibrahim H., El-Haggar, Radwan, Dahab, Mohammed A., Ahmed, Marwa F., Mahdy, Hazem A., Alsantali, Reem I., Elwan, Alaa, Masurier, Nicolas, Fatahala, Samar S.
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
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Phytochemical Characterization of Pterocephalus frutescens with In-Silico Evaluation as Chemotherapeutic Medicine and Oral Pharmacokinetics Prediction Study
El-Hela, Atef A., Bakr, Marwa S. Abu, Hegazy, Mostafa M., Dahab, Mohammed A., Elmaaty, Ayman Abo, Ibrahim, Adel Ehab, El Deeb, Sami, Abbass, Hatem S.
Published in Scientia pharmaceutica (01.01.2023)
Published in Scientia pharmaceutica (01.01.2023)
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New Thieno[2,3-d]pyrimidines as Anticancer VEGFR-2 Inhibitors with Apoptosis Induction: Design, Synthesis, and Biological and In Silico Studies
Sobh, Eman A, Dahab, Mohammed A, Elkaeed, Eslam B, Alsfouk, Bshra A, Ibrahim, Ibrahim M, Metwaly, Ahmed M, Eissa, Ibrahim H
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.01.2024)
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.01.2024)
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Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies
Eissa, Ibrahim H., Elkady, Hazem, Rashed, Mahmoud, Elwan, Alaa, Hagras, Mohamed, Dahab, Mohammed A., Taghour, Mohammed S., Ibrahim, Ibrahim M., Husein, Dalal Z., Elkaeed, Eslam B., Al-ghulikah, Hanan A., Metwaly, Ahmed M., Mahdy, Hazem A.
Published in Heliyon (30.01.2024)
Published in Heliyon (30.01.2024)
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New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
Alanazi, Mohammed M, Elkady, Hazem, Alsaif, Nawaf A, Obaidullah, Ahmad J, Alkahtani, Hamad M, Alanazi, Manal M, Alharbi, Madhawi A, Eissa, Ibrahim H, Dahab, Mohammed A
Published in RSC advances (06.09.2021)
Published in RSC advances (06.09.2021)
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New bis([1,2,4]triazolo)[4,3-a:3′,4′-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation
Alanazi, Mohammed M., Mahdy, Hazem A., Alsaif, Nawaf A., Obaidullah, Ahmad J., Alkahtani, Hamad M., Al-Mehizia, Abdulrahman A., Alsubaie, Sultan M., Dahab, Mohammed A., Eissa, Ibrahim H.
Published in Bioorganic chemistry (01.07.2021)
Published in Bioorganic chemistry (01.07.2021)
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Journal Article
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Alsaif, Nawaf A., Dahab, Mohammed A., Alanazi, Mohammed M., Obaidullah, Ahmad J., Al-Mehizia, Abdulrahman A., Alanazi, Manal M., Aldawas, Saleh, Mahdy, Hazem A., Elkady, Hazem
Published in Bioorganic chemistry (01.05.2021)
Published in Bioorganic chemistry (01.05.2021)
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Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation
Bayoumi, Hatem Hussein, Ibrahim, Mohamed-Kamal, Dahab, Mohammed A, Khedr, Fathalla, El-Adl, Khaled
Published in RSC advances (05.07.2024)
Published in RSC advances (05.07.2024)
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Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers
Bayoumi, Hatem Hussein, Ibrahim, Mohamed-Kamal, Dahab, Mohammed A, Khedr, Fathalla, El-Adl, Khaled
Published in RSC advances (22.08.2024)
Published in RSC advances (22.08.2024)
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Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies
Alsaif, Nawaf A., Taghour, Mohammed S., Alanazi, Mohammed M., Obaidullah, Ahmad J., Alanazi, Wael A., Alasmari, Abdullah, Albassam, Hussam, Dahab, Mohammed A., Mahdy, Hazem A.
Published in Bioorganic & medicinal chemistry (15.09.2021)
Published in Bioorganic & medicinal chemistry (15.09.2021)
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Synthesis of 1,2,4-Triazinones Exploiting the Reactivity of Diazadiene and N‑Isocyanate Intermediates
Vuillermet, Frédéric, Dahab, Mohammed A., Abdelhamid, Dalia, Polat, Dilan E., Gill, Monica A., Beauchemin, André M.
Published in Journal of organic chemistry (17.02.2023)
Published in Journal of organic chemistry (17.02.2023)
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Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site
Eissa, Ibrahim H., Dahab, Mohammed A., Ibrahim, Mohamed K., Alsaif, Nawaf A., Alanazi, A.Z., Eissa, Sally I., Mehany, Ahmed B.M., Beauchemin, André M.
Published in Bioorganic chemistry (01.07.2021)
Published in Bioorganic chemistry (01.07.2021)
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New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies
Elkady, Hazem, Mahdy, Hazem A., Taghour, Mohammed S., Dahab, Mohammed A., Elwan, Alaa, Hagras, Mohamed, Hussein, Mona H., Ibrahim, Ibrahim M., Husein, Dalal Z., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Biochimica et biophysica acta. General subjects (01.06.2024)
Published in Biochimica et biophysica acta. General subjects (01.06.2024)
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