Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds
Boudhar, Aicha, Ng, Xiao Wei, Loh, Chiew Yee, Chia, Wan Ni, Tan, Zhi Ming, Nosten, Francois, Dymock, Brian W, Tan, Kevin S W
Published in Antimicrobial agents and chemotherapy (01.05.2016)
Published in Antimicrobial agents and chemotherapy (01.05.2016)
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Journal Article
Predicting chemotherapeutic drug combinations through gene network profiling
Nguyen, Thi Thuy Trang, Chua, Jacqueline Kia Kee, Seah, Kwi Shan, Koo, Seok Hwee, Yee, Jie Yin, Yang, Eugene Guorong, Lim, Kim Kiat, Pang, Shermaine Yu Wen, Yuen, Audrey, Zhang, Louxin, Ang, Wee Han, Dymock, Brian, Lee, Edmund Jon Deoon, Chen, Ee Sin
Published in Scientific reports (21.01.2016)
Published in Scientific reports (21.01.2016)
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Journal Article
Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis
William, Anthony D, Lee, Angeline C.-H, Poulsen, Anders, Goh, Kee Chuan, Madan, Babita, Hart, Stefan, Tan, Evelyn, Wang, Haishan, Nagaraj, Harish, Chen, Dizhong, Lee, Chai Ping, Sun, Eric T, Jayaraman, Ramesh, Pasha, Mohammad Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Journal Article
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Sharp, Swee Y, Prodromou, Chrisostomos, Boxall, Kathy, Powers, Marissa V, Holmes, Joanna L, Box, Gary, Matthews, Thomas P, Cheung, Kwai-Ming J, Kalusa, Andrew, James, Karen, Hayes, Angela, Hardcastle, Anthea, Dymock, Brian, Brough, Paul A, Barril, Xavier, Cansfield, Julie E, Wright, Lisa, Surgenor, Allan, Foloppe, Nicolas, Hubbard, Roderick E, Aherne, Wynne, Pearl, Laurence, Jones, Keith, McDonald, Edward, Raynaud, Florence, Eccles, Sue, Drysdale, Martin, Workman, Paul
Published in Molecular cancer therapeutics (01.04.2007)
Published in Molecular cancer therapeutics (01.04.2007)
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Journal Article
Antioxidant kinase inhibitors for LRRK2 Parkinson's disease
Sharan, Priyankan, Angeles, Dario C, Ho, Patrick, Dymock, Brian W, Lim, Kah-Leong, Tan, Eng-King
Published in Parkinsonism & related disorders (01.01.2016)
Published in Parkinsonism & related disorders (01.01.2016)
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Journal Article
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P., White, Clara Bantry, Barker, Oliver, Barker, Stephanie, Bennett, James, Brown, David, Boyd, E. Andrew, Brennan, Christopher, Chowdhury, Chandana, Collins, Ian, Convers-Reignier, Emmanuelle, Dymock, Brian W., Fletcher, Rowena, Haydon, David J., Gardiner, Mihaly, Hatcher, Stuart, Ingram, Peter, Lancett, Paul, Mortenson, Paul, Papadopoulos, Konstantinos, Smee, Carol, Thomaides-Brears, Helena B., Tye, Heather, Workman, James, Czaplewski, Lloyd G.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Analysis of Protein Target Interactions of Synthetic Mixtures by Affinity-LC/MS
Singh, Prachi, Madhaiyan, Kalaipriya, Duong-Thi, Minh-Dao, Dymock, Brian W., Ohlson, Sten
Published in SLAS discovery (01.04.2017)
Published in SLAS discovery (01.04.2017)
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Journal Article
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors
Poulsen, Anders, Williams, Meredith, Nagaraj, Harish Mysore, William, Anthony D., Wang, Haishan, Soh, Chang Kai, Xiong, Zheng Chang, Dymock, Brian
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
Blanchard, Stéphanie, Soh, Chang Kai, Lee, Chai Ping, Poulsen, Anders, Bonday, Zahid, Goh, Kay Lin, Goh, Kee Chuan, Goh, Miah Kiat, Pasha, Mohammed Khalid, Wang, Haishan, Williams, Meredith, Wood, Jeanette M., Ethirajulu, Kantharaj, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
4-Amino derivatives of the Hsp90 inhibitor CCT018159
Barril, Xavier, Beswick, Mandy C., Collier, Adam, Drysdale, Martin J., Dymock, Brian W., Fink, Alexandra, Grant, Kate, Howes, Robert, Jordan, Allan M., Massey, Andrew, Surgenor, Allan, Wayne, Joanne, Workman, Paul, Wright, Lisa
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening
Lee, Angeline C.-H., Ramanujulu, Pondy Murugappan, Poulsen, Anders, Williams, Meredith, Blanchard, Stéphanie, Ma, Diana M., Bonday, Zahid, Goh, Kay Lin, Goh, Kee Chuan, Goh, Miah Kiat, Wood, Jeanette, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Journal Article
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity
Ermann, Monika, Riether, Doris, Walker, Edward R., Mushi, Innocent F., Jenkins, James E., Noya-Marino, Beatriz, Brewer, Mark L., Taylor, Malcolm G., Amouzegh, Patricia, East, Stephen P., Dymock, Brian W., Gemkow, Mark J., Kahrs, Andreas F., Ebneth, Andreas, Löbbe, Sabine, O’Shea, Kathy, Shih, Daw-Tsun, Thomson, David
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures
Dymock, Brian, Barril, Xavier, Beswick, Mandy, Collier, Adam, Davies, Nicholas, Drysdale, Martin, Fink, Alexandra, Fromont, Christophe, Hubbard, Roderick E., Massey, Andrew, Surgenor, Allan, Wright, Lisa
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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Journal Article
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
Smith, Nicola F, Hayes, Angela, James, Karen, Nutley, Bernard P, McDonald, Edward, Henley, Alan, Dymock, Brian, Drysdale, Martin J, Raynaud, Florence I, Workman, Paul
Published in Molecular cancer therapeutics (01.06.2006)
Published in Molecular cancer therapeutics (01.06.2006)
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Journal Article
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity
Guertin, Kevin R., Setti, Lina, Qi, Lida, Dunsdon, Rachel M., Dymock, Brian W., Jones, Philip S., Overton, Hilary, Taylor, Mathew, Williams, Glyn, Sergi, Joseph A., Wang, Karen, Peng, Ying, Renzetti, Marcia, Boyce, Rogely, Falcioni, Fiorenza, Garippa, Ralph, Olivier, Andrée R.
Published in Bioorganic & medicinal chemistry letters (01.09.2003)
Published in Bioorganic & medicinal chemistry letters (01.09.2003)
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Journal Article
3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone
Brough, Paul A., Barril, Xavier, Beswick, Mandy, Dymock, Brian W., Drysdale, Martin J., Wright, Lisa, Grant, Kate, Massey, Andrew, Surgenor, Allan, Workman, Paul
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Journal Article
Novel Approaches to the Treatment of Hepatitis C Virus Infection
Dymock, Brian W, Jones, Philip S, Wilson, Francis X
Published in Antiviral Chemistry and Chemotherapy (01.03.2000)
Published in Antiviral Chemistry and Chemotherapy (01.03.2000)
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Book Review
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