Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor
Parry, David, Guzi, Timothy, Shanahan, Frances, Davis, Nicole, Prabhavalkar, Deepa, Wiswell, Derek, Seghezzi, Wolfgang, Paruch, Kamil, Dwyer, Michael P, Doll, Ronald, Nomeir, Amin, Windsor, William, Fischmann, Thierry, Wang, Yaolin, Oft, Martin, Chen, Taiying, Kirschmeier, Paul, Lees, Emma M
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Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening
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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1
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Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2
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Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist
Dwyer, Michael P, Yu, Younong, Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Biju, Purakkattle, Girijavallabhan, Viyyoor, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, Rokosz, Laura L, Kaiser, Bernd, Li, Ge, Wang, Wei, Stauffer, Tara, Ozgur, Lynne, Baldwin, John, Taveras, Arthur G
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
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Structure-guided discovery of cyclin-dependent kinase inhibitors
Fischmann, Thierry O., Hruza, Alan, Duca, José S., Ramanathan, Lata, Mayhood, Todd, Windsor, William T., Le, Hung V., Guzi, Timothy J., Dwyer, Michael P., Paruch, Kamil, Doll, Ronald J., Lees, Emma, Parry, David, Seghezzi, Wolfgang, Madison, Vincent
Published in Biopolymers (01.05.2008)
Published in Biopolymers (01.05.2008)
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Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms
Tong, Ling, Yu, Wensheng, Chen, Lei, Selyutin, Oleg, Dwyer, Michael P, Nair, Anilkumar G, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Yin, Jingjun, Ruck, Rebecca T, Davies, Ian W, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Liu, Rong, Agrawal, Sony, Xia, Ellen, Curry, Stephanie, McMonagle, Patricia, Bystol, Karin, Lahser, Frederick, Carr, Donna, Rokosz, Laura, Ingravallo, Paul, Chen, Shiying, Feng, Kung-I, Cartwright, Mark, Asante-Appiah, Ernest, Kozlowski, Joseph A
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Published in Journal of medicinal chemistry (12.01.2017)
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Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors
Morriello, Gregori J., Dwyer, Michael P., Chen, Yili, Ginetti, Anthony T., Xu, Shimin, Lu, Jun, Abeywickrema, Pravien, Wang, Deping, Crespo, Alejandro, Cabalu, Tamara D., Wilson, Jonathan E., Stachel, Shawn J., Paone, Daniel V., Sinz, Christopher
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
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Enantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates and Diazoacetamides Using Chiral Dirhodium(II) Carboxamide Catalysts
Doyle, Michael P, Austin, Richard E, Bailey, A. Scott, Dwyer, Michael P, Dyatkin, Alexey B, Kalinin, Alexey V, Kwan, Michelle M. Y, Liras, Spiros, Oalmann, Christopher J
Published in Journal of the American Chemical Society (01.05.1995)
Published in Journal of the American Chemical Society (01.05.1995)
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Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors
Tong, Ling, Yu, Wensheng, Coburn, Craig A., Meinke, Peter T., Nair, Anilkumar G., Dwyer, Michael P., Chen, Lei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Fells, James, Hu, Bin, Zhong, Bin, Soll, Richard M., Liu, Rong, Agrawal, Sony, Xia, Ellen, Zhai, Ying, Kong, Rong, Ingravallo, Paul, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
Dwyer, Michael P., Keertikar, Kartik, Paruch, Kamil, Alvarez, Carmen, Labroli, Marc, Poker, Cory, Fischmann, Thierry O., Mayer-Ezell, Rosemary, Bond, Richard, Wang, Yan, Azevedo, Rita, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development
Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael P., Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Allard, Melissa L., Buckle, Ronald N., Gauuan, Polivina Jolicia F., Holst, Christian L., Martin, Gregory S., Naicker, Kannan P., Vellekoop, Samuel, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases
Paruch, Kamil, Dwyer, Michael P, Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J, Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry, Hruza, Alan, Madison, Vincent, Nomeir, Amin A, Wang, Yaolin, Kirschmeier, Paul, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Frances, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A, Paradkar, Vidyadhar M, Park, Haengsoon, Rokosz, Laura R, Stauffer, Tara M, Guzi, Timothy J
Published in ACS medicinal chemistry letters (12.08.2010)
Published in ACS medicinal chemistry letters (12.08.2010)
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Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV‑1 Protease Inhibitors
Bungard, Christopher J, Williams, Peter D, Schulz, Jurgen, Wiscount, Catherine M, Holloway, M. Katharine, Loughran, H. Marie, Manikowski, Jesse J, Su, Hua-Poo, Bennett, David J, Chang, Lehua, Chu, Xin-Jie, Crespo, Alejandro, Dwyer, Michael P, Keertikar, Kartik, Morriello, Gregori J, Stamford, Andrew W, Waddell, Sherman T, Zhong, Bin, Hu, Bin, Ji, Tao, Diamond, Tracy L, Bahnck-Teets, Carolyn, Carroll, Steven S, Fay, John F, Min, Xu, Morris, William, Ballard, Jeanine E, Miller, Michael D, McCauley, John A
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor
Stachel, Shawn J, Berger, Richard, Nomland, Ashley B, Ginnetti, Anthony T, Paone, Daniel V, Wang, Deping, Puri, Vanita, Lange, Henry, Drott, Jason, Lu, Jun, Marcus, Jacob, Dwyer, Michael P, Suon, Sokreine, Uslaner, Jason M, Smith, Sean M
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742
Yu, Wensheng, Zhou, Guowei, Coburn, Craig A., Zeng, Qingbei, Tong, Ling, Dwyer, Michael P., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Chen, Lei, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Selyutin, Oleg, Rosenblum, Stuart B., Lavey, Brian, Nair, Anilkumar G., Heon Kim, Seong, Keertikar, Kerry M., Rokosz, Laura, Agrawal, Sony, Liu, Rong, Xia, Ellen, Zhai, Ying, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity
Yu, Wensheng, Coburn, Craig A., Yang, De-Yi, Meinke, Peter T., Wong, Michael, Rosenblum, Stuart B., Chen, Kevin X., Njoroge, George F., Chen, Lei, Dwyer, Michael P., Jiang, Yueheng, Nair, Anilkumar G., Selyutin, Oleg, Tong, Ling, Zeng, Qingbei, Zhong, Bin, Ji, Tao, Hu, Bin, Agrawal, Sony, Xia, Ellen, Zhai, Ying, Liu, Rong, Kong, Rong, Ingravallo, Paul, Asante-Appiah, Ernest, Nomeir, Amin, Fells, James, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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