Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S
Published in Science translational medicine (28.06.2017)
Published in Science translational medicine (28.06.2017)
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Journal Article
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R
Published in mBio (06.03.2018)
Published in mBio (06.03.2018)
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Journal Article
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Published in Scientific reports (06.03.2017)
Published in Scientific reports (06.03.2017)
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Journal Article
C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines
Loach, Richard P, Fenton, Owen S, Amaike, Kazuma, Siegel, Dustin S, Ozkal, Erhan, Movassaghi, Mohammad
Published in Journal of organic chemistry (21.11.2014)
Published in Journal of organic chemistry (21.11.2014)
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Journal Article
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
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Synthesis and Anticancer Activity of All Known (−)-Agelastatin Alkaloids
Han, Sunkyu, Siegel, Dustin S, Morrison, Karen C, Hergenrother, Paul J, Movassaghi, Mohammad
Published in Journal of organic chemistry (06.12.2013)
Published in Journal of organic chemistry (06.12.2013)
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Journal Article
Genome size drives morphological evolution in organ‐specific ways
Itgen, Michael W., Natalie, Giovanna R., Siegel, Dustin S., Sessions, Stanley K., Mueller, Rachel Lockridge
Published in Evolution (01.07.2022)
Published in Evolution (01.07.2022)
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Journal Article
Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses
Gordon, Calvin J., Walker, Simon M., Tchesnokov, Egor P., Kocincova, Dana, Pitts, Jared, Siegel, Dustin S., Perry, Jason K., Feng, Joy Y., Bilello, John P., Götte, Matthias
Published in The Journal of biological chemistry (01.08.2024)
Published in The Journal of biological chemistry (01.08.2024)
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Journal Article
Total synthesis of all (-)-Agelastatin alkaloids
Movassaghi, Mohammad, Siegel, Dustin S, Han, Sunkyu
Published in Chemical science (Cambridge) (01.01.2010)
Published in Chemical science (Cambridge) (01.01.2010)
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Journal Article
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study
Mackman, Richard L, Sangi, Michael, Sperandio, David, Parrish, Jay P, Eisenberg, Eugene, Perron, Michel, Hui, Hon, Zhang, Lijun, Siegel, Dustin, Yang, Hai, Saunders, Oliver, Boojamra, Constantine, Lee, Gary, Samuel, Dharmaraj, Babaoglu, Kerim, Carey, Anne, Gilbert, Brian E, Piedra, Pedro A, Strickley, Robert, Iwata, Quynh, Hayes, Jaclyn, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Jordan, Robert, Desai, Manoj, Cihlar, Tomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Journal Article
The larval attachment organ of the tropical gar Atractosteus tropicus Gill, 1863 (Lepisosteiformes: Lepisosteidae)
Pinion, Amanda K., Siegel, Dustin S., Britz, Ralf, Martínez‐García, Rafael, Álvarez‐González, Carlos A., Conway, Kevin W.
Published in Journal of fish biology (01.08.2021)
Published in Journal of fish biology (01.08.2021)
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Journal Article
External nasal gland morphology of Eurycea bislineata (Amphibia, Urodela, Plethodontidae)
Trame, Samantha D., Denova, Jacob R., Pereira, Kenzie E., McClelland, Sara J., Gribbins, Kevin M., Rheubert, Justin L., Siegel, Dustin S.
Published in Journal of morphology (1931) (01.08.2022)
Published in Journal of morphology (1931) (01.08.2022)
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Journal Article
Enantioselective Total Synthesis of (−)-Acylfulvene and (−)-Irofulven
Siegel, Dustin S, Piizzi, Grazia, Piersanti, Giovanni, Movassaghi, Mohammad
Published in Journal of organic chemistry (18.12.2009)
Published in Journal of organic chemistry (18.12.2009)
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