Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B‑Cell Lymphomas
Vaswani, Rishi G, Gehling, Victor S, Dakin, Les A, Cook, Andrew S, Nasveschuk, Christopher G, Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C, Campbell, Robert, Lee, Christina, Cantone, Nico, Cummings, Richard T, Normant, Emmanuel, Bellon, Steven F, Albrecht, Brian K, Harmange, Jean-Christophe, Trojer, Patrick, Audia, James E, Zhang, Ying, Justin, Neil, Chen, Shuyang, Wilson, Jon R, Gamblin, Steven J
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
Get full text
Journal Article
Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance
Crawford, Terry D., Vartanian, Steffan, Côté, Alexandre, Bellon, Steve, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Zawadzke, Laura, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G., Stokoe, David
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Get full text
Journal Article
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
Tremblay, Martin, Bonneau, Pierre, Bousquet, Yves, DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Goudreau, Nathalie, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lemke, Christopher T., Mason, Stephen W., Simoneau, Bruno, Surprenant, Simon, Titolo, Steve, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Get full text
Journal Article
Genomic Organization and Molecular Analysis of Virulent Bacteriophage 2972 Infecting an Exopolysaccharide-Producing Streptococcus thermophilus Strain
Lévesque, Céline, Duplessis, Martin, Labonté, Jessica, Labrie, Steve, Fremaux, Christophe, Tremblay, Denise, Moineau, Sylvain
Published in Applied and Environmental Microbiology (01.07.2005)
Published in Applied and Environmental Microbiology (01.07.2005)
Get full text
Journal Article
Characterization of Streptococcus thermophilus Host Range Phage Mutants
Duplessis, Martin, Lévesque, Céline M, Moineau, Sylvain
Published in Applied and Environmental Microbiology (01.04.2006)
Published in Applied and Environmental Microbiology (01.04.2006)
Get full text
Journal Article
Characterization of the cro-ori Region of the Streptococcus thermophilus Virulent Bacteriophage DT1
Lamothe, Geneviève, Lévesque, Céline, Bissonnette, Frédéric, Cochu, Armelle, Vadeboncoeur, Christian, Frenette, Michel, Duplessis, Martin, Tremblay, Denise, Moineau, Sylvain
Published in Applied and Environmental Microbiology (01.03.2005)
Published in Applied and Environmental Microbiology (01.03.2005)
Get full text
Journal Article
Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry
Gagnon, Alexandre, Duplessis, Martin, Fader, Lee
Published in Organic preparations and procedures international (02.02.2010)
Published in Organic preparations and procedures international (02.02.2010)
Get full text
Journal Article
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Taylor, Alexander M., Bailey, Chris, Belmont, Lisa D., Campbell, Robert, Cantone, Nico, Côté, Alexandre, Crawford, Terry D., Cummings, Richard, DeMent, Kevin, Duplessis, Martin, Flynn, Megan, Good, Andrew C., Huang, Hon-Ren, Joshi, Shivangi, Leblanc, Yves, Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Adrianne, Poy, Florence, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Tsui, Vickie, Zawadzke, Laura, Sims, Robert J., Audia, James E., Bellon, Steven F., Magnuson, Steven R., Albrecht, Brian K., Cochran, Andrea G.
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
Get full text
Journal Article
Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite
Beaulieu, Pierre L., Bolger, Gordon, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Stammers, Timothy, Kukolj, George, Duan, Jianmin
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Get full text
Journal Article
Discovery, design, and synthesis of indole-based EZH2 inhibitors
Gehling, Victor S., Vaswani, Rishi G., Nasveschuk, Christopher G., Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C., Campbell, Robert, Lee, Christina, Dakin, Les A., Cook, Andrew S., Gagnon, Alexandre, Harmange, Jean-Christophe, Audia, James E., Cummings, Richard T., Normant, Emmanuel, Trojer, Patrick, Albrecht, Brian K.
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Get full text
Journal Article
표적화 단백질의 분해를 위한 트리시클릭 이종이관능성 화합물
HENDERSON JAMES A, JACKSON KATRINA L, MOUSTAKIM MOSES, LIANG YANKE, ANDERSON COREY DON, GARZA VICTORIA, DUPLESSIS MARTIN, NASVESCHUK CHRISTOPHER G
Year of Publication 17.07.2023
Get full text
Year of Publication 17.07.2023
Patent
뇌 또는 CNS로의 암 전이를 치료하기 위한 EGFR 분해제
HIRD ALEXANDER W, LAZARSKI KIEL, RICCI ANTONIO, MICHAEL RYAN E, RUEHER DANIEL, LIANG YANKE, GOERGLER ANNICK, JAESCHKE GEORG, DUPLESSIS MARTIN, NASVESCHUK CHRISTOPHER G, AHN JAE YOUNG
Year of Publication 14.02.2024
Get full text
Year of Publication 14.02.2024
Patent
A Practical Synthesis of Indoles via a Pd-Catalyzed C–N Ring Formation
Vaswani, Rishi G, Albrecht, Brian K, Audia, James E, Côté, Alexandre, Dakin, Les A, Duplessis, Martin, Gehling, Victor S, Harmange, Jean-Christophe, Hewitt, Michael C, Leblanc, Yves, Nasveschuk, Christopher G, Taylor, Alexander M
Published in Organic letters (15.08.2014)
Published in Organic letters (15.08.2014)
Get full text
Journal Article
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1‑like
Wang, Shumei, Tsui, Vickie, Crawford, Terry D, Audia, James E, Burdick, Daniel J, Beresini, Maureen H, Côté, Alexandre, Cummings, Richard, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Jiang, Ying, Joshi, Shivangi, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Taylor, Alexander M, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
Get full text
Journal Article
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors
Gehling, Victor S., Mcgrath, John P., Duplessis, Martin, Khanna, Avinash, Brucelle, Francois, Vaswani, Rishi G., Cote, Alexandre, Stuckey, Jacob, Watson, Venita, Cummings, Richard T., Balasubramanian, Srividya, Iyer, Priya, Sawant, Priyanka, Good, Andrew C., Albrecht, Brian K., Harmange, Jean-Christophe, Audia, James E., Bellon, Steven F., Trojer, Patrick, Levell, Julian R.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
Get full text
Journal Article