Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives
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Published in Journal of medicinal chemistry (01.08.1991)
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Discovery of the CCR1 Antagonist, BMS-817399, for the Treatment of Rheumatoid Arthritis
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Published in ACS medicinal chemistry letters (10.06.2021)
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Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR
Khan, Javed A., Camac, Daniel M., Low, Simon, Tebben, Andrew J., Wensel, David L., Wright, Martin C., Su, Julie, Jenny, Victoria, Gupta, Ruchira Das, Ruzanov, Max, Russo, Katie A., Bell, Aneka, An, Yongmi, Bryson, James W., Gao, Mian, Gambhire, Pallavi, Baldwin, Eric T., Gardner, Daniel, Cavallaro, Cullen L., Duncia, John V., Hynes, John
Published in Journal of molecular biology (27.02.2015)
Published in Journal of molecular biology (27.02.2015)
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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors
Wityak, John, Hobbs, Frank W., Gardner, Daniel S., Santella, Joseph B., Petraitis, Joseph J., Sun, Jung-Hui, Favata, Margaret F., Daulerio, Andrea J., Horiuchi, Kurumi Y., Copeland, Robert A., Scherle, Peggy A., Jaffe, Bruce D., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Duncia, John V.
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672
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Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives
Duncia, John V, Chiu, Andrew T, Carini, David J, Gregory, George B, Johnson, Alexander L, Price, William A, Wells, Gregory J, Wong, Pancras C, Calabrese, Joseph C, Timmermans, Pieter B. M. W. M
Published in Journal of medicinal chemistry (01.05.1990)
Published in Journal of medicinal chemistry (01.05.1990)
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The discovery of BMS-457, a potent and selective CCR1 antagonist
Gardner, Daniel S., Santella, Joseph B., Duncia, John V., Carter, Percy H., Dhar, T.G.Murali, Wu, Hong, Guo, Weiwei, Cavallaro, Cullen, Van Kirk, Katy, Yarde, Melissa, Briceno, Stephanie W., Robert Grafstrom, R., Liu, Richard, Patel, Sima R., Tebben, Andrew J., Camac, Dan, Khan, Javed, Watson, Andrew, Yang, Guchen, Rose, Anne, Foster, William R., Cvijic, Mary Ellen, Davies, Paul, Hynes, John
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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면역억제제로서 유용한 마크로시클릭 PAD4 억제제
DUNCIA JOHN V, ANNUNZIATO CHRISTOPHER, GARDNER DANIEL S, NGU KHEHYONG
Year of Publication 12.10.2022
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Year of Publication 12.10.2022
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Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5
Carter, Percy H, Brown, Gregory D, Cherney, Robert J, Batt, Douglas G, Chen, Jing, Clark, Cheryl M, Cvijic, Mary Ellen, Duncia, John V, Ko, Soo S, Mandlekar, Sandhya, Mo, Ruowei, Nelson, David J, Pang, Jian, Rose, Anne V, Santella, Joseph B, Tebben, Andrew J, Traeger, Sarah C, Xu, Songmei, Zhao, Qihong, Barrish, Joel C
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
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Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: The discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis
Santella, Joseph B., Gardner, Daniel S., Yao, Wenqing, Shi, Chongsheng, Reddy, Prabhakar, Tebben, Andrew J., DeLucca, George V., Wacker, Dean A., Watson, Paul S., Welch, Patricia K., Wadman, Eric A., Davies, Paul, Solomon, Kimberly A., Graden, Dani M., Yeleswaram, Swamy, Mandlekar, Sandhya, Kariv, Ilona, Decicco, Carl P., Ko, Soo S., Carter, Percy H., Duncia, John V.
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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PAD4 억제제로서의 치환된 벤즈이미다졸
DUNCIA JOHN V, SANTELLA JOSEPH B, GARDNER DANIEL S, ANNUNZIATO CHRISTOPHER, NGU KHEHYONG
Year of Publication 20.04.2021
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Year of Publication 20.04.2021
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From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3 S)-3-benzylpiperidine in a series of potent CCR3 antagonists
Gardner, Daniel S., Santella, Joseph B., Tebben, Andrew J., Batt, Douglas G., Ko, Soo S., Traeger, Sarah C., Welch, Patricia K., Wadman, Eric A., Davies, Paul, Carter, Percy H., Duncia, John V.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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헤테로시클릭 PAD4 억제제
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Year of Publication 18.10.2022
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Year of Publication 18.10.2022
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Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists
Varnes, Jeffrey G, Gardner, Daniel S, Santella, Joseph B, Duncia, John V, Estrella, Melissa, Watson, Paul S, Clark, Cheryl M, Ko, Soo S, Welch, Patricia, Covington, Maryanne, Stowell, Nicole, Wadman, Eric, Davies, Paul, Solomon, Kimberley, Newton, Robert C, Trainor, George L, Decicco, Carl P, Wacker, Dean A
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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