Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
Bubser, Michael, Bridges, Thomas M, Dencker, Ditte, Gould, Robert W, Grannan, Michael, Noetzel, Meredith J, Lamsal, Atin, Niswender, Colleen M, Daniels, J. Scott, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Byers, Frank W, Wess, Jürgen, Duggan, Mark E, Dunlop, John, Wood, Michael W, Brandon, Nicholas J, Wood, Michael R, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K
Published in ACS chemical neuroscience (15.10.2014)
Published in ACS chemical neuroscience (15.10.2014)
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Challenges in the development of an M-4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Wood, Michael R., Noetzel, Meredith J., Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B., Weiner, Rebecca L., Cho, Hyekyung P., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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Journal Article
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
Lindsley, Craig W., Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article
Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes
Fan, Jianjia, Zareyan, Shahab, Zhao, Wenchen, Shimizu, Yoko, Pfeifer, Tom A, Tak, Jun-Hyung, Isman, Murray B, Van den Hoven, Bernard, Duggan, Mark E, Wood, Michael W, Wellington, Cheryl L, Kulic, Iva
Published in PloS one (06.09.2016)
Published in PloS one (06.09.2016)
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Challenges in the development of an M-4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Bertron, Jeanette L., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
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A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
Kinney, Gene G, O'Brien, Julie A, Lemaire, Wei, Burno, Maryann, Bickel, Denise J, Clements, Michelle K, Chen, Tsing-Bau, Wisnoski, David D, Lindsley, Craig W, Tiller, Philip R, Smith, Sheri, Jacobson, Marlene A, Sur, Cyrille, Duggan, Mark E, Pettibone, Douglas J, Conn, P Jeffrey, Williams, Jr, David L
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
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State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 – Relation to antipsychotic-like drug effects
Gould, Robert W., Nedelcovych, Michael T., Gong, Xuewen, Tsai, Erica, Bubser, Michael, Bridges, Thomas M., Wood, Michael R., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Wood, Michael W., Ivarsson, Magnus, Noetzel, Meredith J., Daniels, J. Scott, Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Published in Neuropharmacology (01.03.2016)
Published in Neuropharmacology (01.03.2016)
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Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia
Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Poslusney, Michael S., Nance, Kellie D., Hurtado, Miguel A., Luscombe, Vincent B., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Bubser, Michael, Blobaum, Anna L., Engers, Darren W., Niswender, Colleen M., Jones, Carrie K., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
DeFeo-Jones, Deborah, Barnett, Stanley F, Fu, Sheng, Hancock, Paula J, Haskell, Kathleen M, Leander, Karen R, McAvoy, Elizabeth, Robinson, Ronald G, Duggan, Mark E, Lindsley, Craig W, Zhao, Zhijian, Huber, Hans E, Jones, Raymond E
Published in Molecular cancer therapeutics (01.02.2005)
Published in Molecular cancer therapeutics (01.02.2005)
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A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain
O'Brien, Julie A, Lemaire, Wei, Wittmann, Marion, Jacobson, Marlene A, Ha, Sookhee N, Wisnoski, David D, Lindsley, Craig W, Schaffhauser, Hervé J, Rowe, Blake, Sur, Cyrille, Duggan, Mark E, Pettibone, Douglas J, Conn, P Jeffrey, Williams, Jr, David L
Published in The Journal of pharmacology and experimental therapeutics (01.05.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2004)
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Journal Article
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands
Schmidt, Azriel, Harada, Shun-Ichi, Kimmel, Donald B., Bai, Chang, Chen, Fang, Rutledge, Su Jane, Vogel, Robert L., Scafonas, Angela, Gentile, Michael A., Nantermet, Pascale V., McElwee-Witmer, Sheila, Pennypacker, Brenda, Masarachia, Patricia, Sahoo, Soumya P., Kim, Yuntae, Meissner, Robert S., Hartman, George D., Duggan, Mark E., Rodan, Gideon A., Towler, Dwight A., Ray, William J.
Published in The Journal of biological chemistry (25.12.2009)
Published in The Journal of biological chemistry (25.12.2009)
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Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo
Sivakumaran, Sudhir, Cardarelli, Ross A, Maguire, Jamie, Kelley, Matt R, Silayeva, Liliya, Morrow, Danielle H, Mukherjee, Jayanta, Moore, Yvonne E, Mather, Robert J, Duggan, Mark E, Brandon, Nicholas J, Dunlop, John, Zicha, Stephen, Moss, Stephen J, Deeb, Tarek Z
Published in The Journal of neuroscience (27.05.2015)
Published in The Journal of neuroscience (27.05.2015)
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Design, Synthesis, and In Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived from a Series of [4-Phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl Benzamides
Lindsley, Craig W., Zhao, Zhijian, Leister, William H., O'Brien, Julie, Lemaire, Wei, Williams Jr, David L., Chen, Tsing-Bau, Chang, Raymond S. L., Burno, Maryann, Jacobson, Marlene A., Sur, Cyrille, Kinney, Gene G., Pettibone, Douglas J., Tiller, Philip R., Smith, Sheri, Tsou, Nancy N., Duggan, Mark E., Conn, P. Jeffrey, Hartman, George D.
Published in ChemMedChem (11.08.2006)
Published in ChemMedChem (11.08.2006)
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Journal Article
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154
Gould, Robert W., Grannan, Michael D., Gunter, Barak W., Ball, Jacob, Bubser, Michael, Bridges, Thomas M., Wess, Jurgen, Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity
Cardarelli, Ross A, Jones, Karen, Pisella, Lucie I, Wobst, Heike J, McWilliams, Lisa J, Sharpe, Paul M, Burnham, Matthew P, Baker, David J, Chudotvorova, Ilona, Guyot, Justine, Silayeva, Liliya, Morrow, Danielle H, Dekker, Niek, Zicha, Stephen, Davies, Paul A, Holenz, Jörg, Duggan, Mark E, Dunlop, John, Mather, Robert J, Wang, Qi, Medina, Igor, Brandon, Nicholas J, Deeb, Tarek Z, Moss, Stephen J
Published in Nature medicine (07.12.2017)
Published in Nature medicine (07.12.2017)
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Journal Article
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M 4 PAM VU0467154
Gould, Robert W, Grannan, Michael D, Gunter, Barak W, Ball, Jacob, Bubser, Michael, Bridges, Thomas M, Wess, Jurgen, Wood, Michael W, Brandon, Nicholas J, Duggan, Mark E, Niswender, Colleen M, Lindsley, Craig W, Conn, P Jeffrey, Jones, Carrie K
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity
Johansson, Patrik, Kaspersson, Karin, Gurrell, Ian K, Bäck, Elisabeth, Eketjäll, Susanna, Scott, Clay W, Cebers, Gvido, Thorne, Philip, McKenzie, Michael J, Beaton, Haydn, Davey, Paul, Kolmodin, Karin, Holenz, Jörg, Duggan, Mark E, Budd Haeberlein, Samantha, Bürli, Roland W
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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