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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

by Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal
Published in Journal of medicinal chemistry (10.05.2018)

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Journal Article

Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

by Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G
Published in Journal of medicinal chemistry (14.07.2016)

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Journal Article

Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (23.04.2015)

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Journal Article

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)

by Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal
Published in Journal of medicinal chemistry (10.05.2018)

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Journal Article

Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sebastien L., Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamontt, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Remy, Norman, Richard A., Peru, Aurelien, Pink, Jennifer H., Ple, Patrick A., Roberts, Bryan, Scott, James S.
Published in Journal of medicinal chemistry (23.04.2015)

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Journal Article

Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)

Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)

by Degorce, Sébastien L, Boyd, Scott, Curwen, Jon O, Ducray, Richard, Halsall, Christopher T, Jones, Clifford D, Lach, Franck, Lenz, Eva M, Pass, Martin, Pass, Sarah, Trigwell, Catherine
Published in Journal of medicinal chemistry (26.05.2016)

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Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline

Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline

by Ducray, Richard, Jones, Clifford D., Jung, Frederic H., Simpson, Iain, Curwen, Jon, Pass, Martin
Published in Bioorganic & medicinal chemistry letters (15.08.2011)

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Journal Article

Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

by Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G
Published in Journal of medicinal chemistry (26.07.2018)

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Journal Article

Two Novel 1,2,4,5-Tetrazines that Participate in Inverse Electron Demand Diels−Alder Reactions with an Unexpected Regioselectivity

Two Novel 1,2,4,5-Tetrazines that Participate in Inverse Electron Demand Diels−Alder Reactions with an Unexpected Regioselectivity

by Hamasaki, Akiyuki, Ducray, Richard, Boger, Dale L
Published in Journal of organic chemistry (06.01.2006)

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Journal Article

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

by DUCRAY, Richard, BALLARD, Peter, BARLAAM, Bernard C, HICKINSON, Mark D, KETTLE, Jason G, OGILVIE, Donald J, TRIGWELL, Catherine B
Published in Bioorganic & medicinal chemistry (01.02.2008)

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Journal Article

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

by Ducray, Richard, Simpson, Iain, Jung, Frederic H., Nissink, J. Willem M., Kenny, Peter W., Fitzek, Martina, Walker, Graeme E., Ward, Lara T., Hudson, Kevin
Published in Bioorganic & medicinal chemistry letters (15.08.2011)

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Journal Article

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

by Bardelle, Catherine, Barlaam, Bernard, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Ducray, Richard, Green, Isabelle, Brempt, Christine Lambert-van der, Olivier, Annie, Read, Jon
Published in Bioorganic & medicinal chemistry letters (01.11.2010)

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Journal Article

Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (14.04.2016)

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Journal Article

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

by Barlaam, Bernard, Ducray, Richard, Brempt, Christine Lambert-van der, Plé, Patrick, Bardelle, Catherine, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Kettle, Jason G., Read, Jon
Published in Bioorganic & medicinal chemistry letters (15.04.2011)

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Journal Article

Total Synthesis of (±)-FR66979

Total Synthesis of (±)-FR66979

by Ducray, Richard, Ciufolini, Marco A.
Published in Angewandte Chemie (International ed.) (16.12.2002)

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Journal Article

A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2- a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5- a]pyridines

A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2- a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5- a]pyridines

by Ducray, Richard, Boutron, Pascal, Didelot, Myriam, Germain, Hervé, Lach, Franck, Lamorlette, Maryannick, Legriffon, Antoine, Maudet, Mickael, Ménard, Morgan, Pasquet, Georges, Renaud, Fabrice, Simpson, Iain, Young, Gail L.
Published in Tetrahedron letters (08.09.2010)

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Journal Article

Abstract B238: Novel imidazo[1,2- a ]pyridines as inhibitors of the IGF-1R tyrosine kinase

Abstract B238: Novel imidazo[1,2- a ]pyridines as inhibitors of the IGF-1R tyrosine kinase

by Ducray, Richard, Simpson, Iain, Jones, Clifford D., Curwen, Jon, Trigwell, Catherine B., Veldman-Jones, Margaret H., Fitzek, Martina, Walker, Graeme E., Ward, Lara T., Hudson, Kevin, Pass, Martin
Published in Molecular cancer therapeutics (12.11.2011)

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Journal Article

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

by Barlaam, Bernard, Ballard, Peter, Bradbury, Robert H., Ducray, Richard, Germain, Hervé, Hickinson, D. Mark, Hudson, Kevin, Kettle, Jason G., Klinowska, Teresa, Magnien, Françoise, Ogilvie, Donald J., Olivier, Annie, Pearson, Stuart E., Scott, James S., Suleman, Abid, Trigwell, Cath B., Vautier, Michel, Whittaker, Robin D., Wood, Robin
Published in Bioorganic & medicinal chemistry (15.01.2008)

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Journal Article

Novel 3-alkoxy-1 H-pyrazolo[3,4- d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Novel 3-alkoxy-1 H-pyrazolo[3,4- d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

by Ducray, Richard, Ballard, Peter, Barlaam, Bernard C., Hickinson, Mark D., Kettle, Jason G., Ogilvie, Donald J., Trigwell, Catherine B.
Published in Bioorganic & medicinal chemistry letters (2008)

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Journal Article

PYRIMIDINE DERIVATIVES 934

PYRIMIDINE DERIVATIVES 934

by DUCRAY RICHARD, KETTLE JASON GRANT, BARLAAM BERNARD CHRISTOPHE
Year of Publication 23.04.2010

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