Search Results - "DUCKWORTH, DM" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

by Hayes, Philip, Meadows, Helen J, Gunthorpe, Martin J, Harries, Mark H, Duckworth, D.Malcolm, Cairns, William, Harrison, David C, Clarke, Catherine E, Ellington, Kathryn, Prinjha, Rab K, Barton, Amanda J.L, Medhurst, Andrew D, Smith, Graham D, Topp, Simon, Murdock, Paul, Sanger, Gareth J, Terrett, John, Jenkins, Owen, Benham, Christopher D, Randall, Andrew D, Gloger, Isro S, Davis, John B
Published in Pain (Amsterdam) (01.11.2000)

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The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K + channels TREK-1 and TRAAK

The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K + channels TREK-1 and TRAAK

by Meadows, H.J., Chapman, C.G., Duckworth, D.M., Kelsell, R.E., Murdock, P.R., Nasir, S., Rennie, G., Randall, A.D.
Published in Brain research (16.02.2001)

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A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

by Lovell, Peter J, Bromidge, Steven M, Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T, Jennings, Andrew J, King, Frank D, Middlemiss, Derek N, Rahman, Shirley K, Saunders, Damian V, Collin, Lissa L, Hagan, Jim J, Riley, Graham J, Thomas, David R
Published in Journal of medicinal chemistry (10.02.2000)

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Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

by Bromidge, Steven M, Dabbs, Steven, Davies, David T, Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T, Gaster, Laramie M, Ham, Peter, Jones, Graham E, King, Frank D, Mulholland, Keith R, Saunders, Damian V, Wyman, Paul A, Blaney, Frank E, Clarke, Stephen E, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Lightowler, Sean, Middlemiss, Derek N, Trail, Brenda, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (23.03.2000)

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In silico identification of novel therapeutic targets

In silico identification of novel therapeutic targets

by Duckworth, D Malcolm, Sanseau, Philippe
Published in Drug discovery today (01.06.2002)

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The selective 5-HT1B receptor inverse agonist 1 '-methyl-5[[2 '-methyl-4 '-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4 '-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo

The selective 5-HT1B receptor inverse agonist 1 '-methyl-5[[2 '-methyl-4 '-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4 '-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo

by Gaster, LM, Blaney, FE, Davies, S, Duckworth, DM, Ham, P, Jenkins, S, Jennings, AJ, Joiner, GF, King, FD, Mulholland, KR, Wyman, PA, Hagan, JJ, Hatcher, J, Jones, BJ, Middlemiss, DN, Price, GW, Riley, G, Roberts, C, Routledge, C, Selkirk, J, Slade, PD
Published in Journal of medicinal chemistry (09.04.1998)

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(R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7 Receptor Antagonist

(R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7 Receptor Antagonist

by Forbes, Ian T, Dabbs, Steven, Duckworth, D. Malcolm, Jennings, Andrew J, King, Frank D, Lovell, Peter J, Brown, Anthony M, Collin, Lissa, Hagan, Jim J, Middlemiss, Derek N, Riley, Graham J, Thomas, David R, Upton, Neil
Published in Journal of medicinal chemistry (26.02.1998)

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Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family

Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family

by Barnes, Michael R, Duckworth, D.Malcolm, Beeley, Lee J
Published in Trends in pharmacological sciences (Regular ed.) (01.10.1998)

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Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

by Bromidge, Steven M, Dabbs, Steven, Davies, David T, Duckworth, D. Malcolm, Forbes, Ian T, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Starr, Susannah, Thewlis, Kevin M, Wyman, Paul A, Blaney, Frank E, Naylor, Christopher B, Bailey, Fiona, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (07.05.1998)

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The impact of genomics on drug design

The impact of genomics on drug design

by Beeley, Lee J., Malcolm Duckworth, D.
Published in Drug discovery today (01.11.1996)

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1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

by BROMIDGE, S. M, DAVIES, S, LIGHTOWLER, S, MIDDLEMISS, D. N, RILEY, G. J, TRAIL, B, WOOD, M. D, DUCKWORTH, D. M, FORBES, I. T, JONES, G. E, JONES, J, KING, F. D, BLACKBURN, T. P, HOLLAND, V, KENNETT, G. A
Published in Bioorganic & medicinal chemistry letters (21.08.2000)

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1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents

by BROMIDGE, S. M, DABBS, S, HOLLAND, V, KENNETT, G. A, LIGHTOWLER, S, MIDDLEMISS, D. N, RILEY, G. J, TRAIL, B, WOOD, M. D, DAVIES, S, DUCKWORTH, D. M, FORBES, I. T, JONES, G. E, JONES, J, KING, F. D, SAUNDERS, D. V, BLACKBURN, T. P
Published in Bioorganic & medicinal chemistry letters (21.08.2000)

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Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT2C/2B Receptor Antagonists

Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT2C/2B Receptor Antagonists

by Forbes, Ian T, Dabbs, Steven, Duckworth, D. Malcolm, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Blaney, Frank E, Naylor, Christopher B, Baxter, Gordon S, Blackburn, Thomas P, Kennett, Guy A, Wood, Martyn D
Published in Journal of medicinal chemistry (06.12.1996)

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Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists

Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists

by BROMIDGE, S. M, DABBS, S, SAUNDERS, D. V, THEWLIS, K. M, VYAS, D, BLACKBURN, T. P, HOLLAND, V, KENNETT, G. A, RILEY, G. J, WOOD, M. D, DAVIES, D. T, DAVIES, S, DUCKWORTH, D. M, FORBES, I. T, GADRE, A, HAM, P, JONES, G. E, KING, F. D
Published in Bioorganic & medicinal chemistry (01.12.1999)

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BIOGENETICALLY PATTERNED SYNTHESIS OF CADAMBINE

BIOGENETICALLY PATTERNED SYNTHESIS OF CADAMBINE

by BROWN, RT, DUCKWORTH, DM, SANTOS, CAM
Published in Tetrahedron letters (22.04.1991)

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Co-cyclizations of nitrogen-containing acetylenes induced by a nickel triphenylphosphine complex to give aminoindane, isoindoline and isoindolinone derivatives

Co-cyclizations of nitrogen-containing acetylenes induced by a nickel triphenylphosphine complex to give aminoindane, isoindoline and isoindolinone derivatives

by Duckworth, DM, LeeWong, S, Slawin, AMZ, Smith, EH, Williams, DJ
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.04.1996)

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Magnetic properties and metal-metal interactions in mixed-metal (Pt2M) trimers (M = Ni, Co)

Magnetic properties and metal-metal interactions in mixed-metal (Pt2M) trimers (M = Ni, Co)

by Duckworth, Darrell M, Goodgame, David M. L, Hitchman, Michael A, Lippert, Bernhard, Murray, Keith
Published in Inorganic chemistry (01.06.1987)

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Conversion of secologanin into elenolic acid and 18-oxayohimban alkaloids

Conversion of secologanin into elenolic acid and 18-oxayohimban alkaloids

by Brown, Richard T., Chapple, C. Lyn, Duckworth, D. Malcolm, Platt, Ray
Published in Journal of the Chemical Society, Perkin Transactions 1 (1976)

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C-20 configuration in adirubine

C-20 configuration in adirubine

by Brown, Richard T., Duckworth, D. Malcolm
Published in Journal of the Chemical Society. Chemical communications (1976)

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