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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
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Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
Xu, Daigen, Rowland, Steven E, Clark, Patsy, Giroux, André, Côté, Bernard, Guiral, Sébastien, Salem, Myriam, Ducharme, Yves, Friesen, Richard W, Méthot, Nathalie, Mancini, Joseph, Audoly, Laurent, Riendeau, Denis
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor
Ducharme, Yves, Blouin, Marc, Brideau, Christine, Châteauneuf, Anne, Gareau, Yves, Grimm, Erich L, Juteau, Hélène, Laliberté, Sébastien, MacKay, Bruce, Massé, Frédéric, Ouellet, Marc, Salem, Myriam, Styhler, Angela, Friesen, Richard W
Published in ACS medicinal chemistry letters (08.07.2010)
Published in ACS medicinal chemistry letters (08.07.2010)
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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidines
Chen, Austin, Aspiotis, Renee, Campeau, Louis-Charles, Cauchon, Elizabeth, Chefson, Amadine, Ducharme, Yves, Falgueyret, Jean-Pierre, Gagné, Sébastien, Han, Yongxin, Houle, Robert, Laliberté, Sébastien, Larouche, Guillaume, Lévesque, Jean-François, McKay, Dan, Percival, David
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Substituted coumarins as potent 5-lipoxygenase inhibitors
Grimm, Erich L., Brideau, Christine, Chauret, Nathalie, Chan, Chi-Chung, Delorme, Daniel, Ducharme, Yves, Ethier, Diane, Falgueyret, Jean-Pierre, Friesen, Richard W., Guay, Jocelyne, Hamel, Pierre, Riendeau, Denis, Soucy-Breau, Chantal, Tagari, Philip, Girard, Yves
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain
Colucci, John, Boyd, Michael, Berthelette, Carl, Chiasson, Jean-Francois, Wang, Zhaoyin, Ducharme, Yves, Friesen, Rick, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Therien, Alex G., Clarke, Patsy, Rowland, Steve, Xu, Daigen, Han, Yongxin
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding
Chauret, Nathalie, Guay, Daniel, Li, Chun, Day, Stephen, Silva, José, Blouin, Marc, Ducharme, Yves, Yergey, James A., Nicoll-Griffith, Deborah A.
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability
Delorme, Daniel, Ducharme, Yves, Brideau, Christine, Chan, Chi-Chung, Chauret, Nathalie, Desmarais, Sylvie, Dubé, Daniel, Falgueyret, Jean-Pierre, Fortin, Réjean, Guay, Jocelyne, Hamel, Pierre, Jones, Tom R, Lépine, Carole, Li, Chun, McAuliffe, Malia, McFarlane, Cyril S, Nicoll-Griffith, Deborah A, Riendeau, Denis, Yergey, James A, Girard, Yves
Published in Journal of medicinal chemistry (27.09.1996)
Published in Journal of medicinal chemistry (27.09.1996)
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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
Côté, Bernard, Boulet, Louise, Brideau, Christine, Claveau, David, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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The next generation of PDE4 inhibitors
Huang, Zheng, Ducharme, Yves, Macdonald, Dwight, Robichaud, Annette
Published in Current Opinion in Chemical Biology (01.08.2001)
Published in Current Opinion in Chemical Biology (01.08.2001)
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Book Review
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Biarylimidazoles as inhibitors of microsomal prostaglandin E 2 synthase-1
Wu, Tom Y.H., Juteau, Hélène, Ducharme, Yves, Friesen, Richard W., Guiral, Sébastien, Dufresne, Lynn, Poirier, Hugo, Salem, Myriam, Riendeau, Denis, Mancini, Joseph, Brideau, Christine
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Substituted 4-(2,2-diphenylethyl)pyridine-n-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters
FRENETTE, Richard, BLOUIN, Marc, MASSON, Paul, MCAULIFFE, Malia, GIRARD, Yves, BRIDEAU, Christine, CHAURET, Nathalie, DUCHARME, Yves, FRIESEN, Richard W, HAMEL, Pierre, JONES, Tom R, LALIBERTE, France, CHUN LI
Published in Bioorganic & medicinal chemistry letters (01.10.2002)
Published in Bioorganic & medicinal chemistry letters (01.10.2002)
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Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases
Gallant, Michel, Beaulieu, Christian, Berthelette, Carl, Colucci, John, Crackower, Michael A., Dalton, Chad, Denis, Danielle, Ducharme, Yves, Friesen, Richard W., Guay, Daniel, Gervais, François G., Hamel, Martine, Houle, Robert, Krawczyk, Connie M., Kosjek, Birgit, Lau, Stephen, Leblanc, Yves, Lee, Ernest E., Levesque, Jean-François, Mellon, Christophe, Molinaro, Carmela, Mullet, Wayne, O’Neill, Gary P., O’Shea, Paul, Sawyer, Nicole, Sillaots, Susan, Simard, Daniel, Slipetz, Deborah, Stocco, Rino, Sørensen, Dan, Truong, Vouy Linh, Wong, Elizabeth, Wu, Jin, Zaghdane, Helmi, Wang, Zhaoyin
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E-2 Subtype 4 Receptor Antagonist
Blouin, Marc, Han, Yongxin, Burch, Jason, Farand, Julie, Mellon, Christophe, Gaudreault, Mireille, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Vigneault, Erika, Therien, Alex, Clark, Patsy, Rowland, Steve, Xu, Daigen, O'Neill, Gary, Ducharme, Yves, Friesen, Rick
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Trisubstituted ureas as potent and selective mPGES-1 inhibitors
Chiasson, Jean-François, Boulet, Louise, Brideau, Christine, Chau, Anh, Claveau, David, Côté, Bernard, Ethier, Diane, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Roy, Patrick, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E2 Subtype 4 Receptor Antagonist
Blouin, Marc, Han, Yongxin, Burch, Jason, Farand, Julie, Mellon, Christophe, Gaudreault, Mireille, Wrona, Mark, Lévesque, Jean-François, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Vigneault, Erika, Therien, Alex, Clark, Patsy, Rowland, Steve, Xu, Daigen, O’Neill, Gary, Ducharme, Yves, Friesen, Rick
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Design and synthesis of potent, isoxazole-containing renin inhibitors
Fournier, Pierre-André, Arbour, Mélissa, Cauchon, Elizabeth, Chen, Austin, Chefson, Amandine, Ducharme, Yves, Falgueyret, Jean-Pierre, Gagné, Sébastien, Grimm, Erich, Han, Yongxin, Houle, Robert, Lacombe, Patrick, Lévesque, Jean-François, MacDonald, Dwight, Mackay, Bruce, McKay, Dan, Percival, M. David, Ramtohul, Yeeman, St-Jacques, René, Toulmond, Sylvie
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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