MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
Fell, Matthew J, Mirescu, Christian, Basu, Kallol, Cheewatrakoolpong, Boonlert, DeMong, Duane E, Ellis, J Michael, Hyde, Lynn A, Lin, Yinghui, Markgraf, Carrie G, Mei, Hong, Miller, Michael, Poulet, Frederique M, Scott, Jack D, Smith, Michelle D, Yin, Zhizhang, Zhou, Xiaoping, Parker, Eric M, Kennedy, Matthew E, Morrow, John A
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
Get full text
Journal Article
Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
Get full text
Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease
Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
Get full text
Journal Article
A Novel Method for the Preparation of 4‑Arylimidazolones
DeMong, Duane E, Ng, Irene, Miller, Michael W, Stamford, Andrew W
Published in Organic letters (07.06.2013)
Published in Organic letters (07.06.2013)
Get full text
Journal Article
Asymmetric Synthesis of (2S,3R)-Capreomycidine and the Total Synthesis of Capreomycin IB
DeMong, Duane E, Williams, Robert M
Published in Journal of the American Chemical Society (16.07.2003)
Published in Journal of the American Chemical Society (16.07.2003)
Get full text
Journal Article
Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs
Chen, Helen Y., Plummer, Christopher W., Xiao, Dong, Chobanian, Harry R., DeMong, Duane, Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Souza, Sarah, Tatosian, Daniel A., Chen, Qing, Hafey, Michael J., Houle, Robert, Nolting, Andrew F., Orr, Robert, Ehrhart, Juliann, Weinglass, Adam B., Tschirret-Guth, Richard, Howard, Andrew D., Colletti, Steven L.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
Get full text
Journal Article
Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists
Xia, Mingde, Hou, Cuifen, DeMong, Duane E, Pollack, Scott R, Pan, Meng, Brackley, James A, Jain, Nareshkumar, Gerchak, Chrissy, Singer, Monica, Malaviya, Ravi, Matheis, Michele, Olini, Gil, Cavender, Druie, Wachter, Michael
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
Get full text
Journal Article
Asymmetric Synthesis of (+)-Hypusine
Jain, Rajendra P, Albrecht, Brian K, DeMong, Duane E, Williams, Robert M
Published in Organic letters (27.12.2001)
Published in Organic letters (27.12.2001)
Get full text
Journal Article
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins
Fryszkowska, Anna, An, Chihui, Alvizo, Oscar, Banerjee, Goutami, Canada, Keith A., Cao, Yang, DeMong, Duane, Devine, Paul N., Duan, Da, Elgart, David M., Farasat, Iman, Gauthier, Donald R., Guidry, Erin N., Jia, Xiujuan, Kong, Jongrock, Kruse, Nikki, Lexa, Katrina W., Makarov, Alexey A., Mann, Benjamin F., Milczek, Erika M., Mitchell, Vesna, Nazor, Jovana, Neri, Claudia, Orr, Robert K., Orth, Peter, Phillips, Eric M., Riggins, James N., Schafer, Wes A., Silverman, Steven M., Strulson, Christopher A., Subramanian, Nandhitha, Voladri, Rama, Yang, Hao, Yang, Jie, Yi, Xiang, Zhang, Xiyun, Zhong, Wendy
Published in Science (American Association for the Advancement of Science) (17.06.2022)
Published in Science (American Association for the Advancement of Science) (17.06.2022)
Get full text
Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
Get full text
Journal Article
ChemInform Abstract: A Novel Method for the Preparation of 4-Arylimidazolones
DeMong, Duane E., Ng, Irene, Miller, Michael W., Stamford, Andrew W.
Published in ChemInform (01.10.2013)
Published in ChemInform (01.10.2013)
Get full text
Journal Article
Abstract PR017: Discovery and clinical evaluation of a potent and selective A2A/2B dual receptor antagonist
DeMong, Duane, Ranganath, Sheila, Cumming, Jared, Larsen, Matthew, Zhang, Yonglian, Plummer, Christopher, Ali, Amjad, Palmieri, Anthony, Barry, Evan, Daublain, Pierre, Gupta, Pranav, Chatterjee, Manash, Giranda, Vincent, Presland, Jeremy, Schneider, Sebastian, Ciaccio, Paul, Tatosian, Daniel, Sather, Aaron, Turnbull, Ben, Silverman, Steven, Chobanian, Harry, Krishnamurthy, Harini, Wnek, Richard, Afshar, Roshi, Crowley, Stephen, Miller, Alita, Ayers, Mark, Whitehead, Alan, Hinton, Marlene, Chiang, Derek, Orr, Robert, Chrencik, Jill
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
Get full text
Journal Article
The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist
DeMong, Duane, Dai, Xing, Hwa, Joyce, Miller, Michael, Lin, Sue-Ing, Kang, Ling, Stamford, Andrew, Greenlee, William, Yu, Wensheng, Wong, Michael, Lavey, Brian, Kozlowski, Joseph, Zhou, Guowei, Yang, De-Yi, Patel, Bhuneshwari, Soriano, Aileen, Zhai, Ying, Sondey, Christopher, Zhang, Hongtao, Lachowicz, Jean, Grotz, Diane, Cox, Kathleen, Morrison, Richard, Andreani, Teresa, Cao, Yang, Liang, Mark, Meng, Tao, McNamara, Paul, Wong, Jesse, Bradley, Prudence, Feng, Kung-I, Belani, Jitendra, Chen, Ping, Dai, Peng, Gauuan, Jolicia, Lin, Peishan, Zhao, He
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
Get full text
Journal Article
Synthesis and structure–activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists
Xia, Mingde, Hou, Cuifen, DeMong, Duane, Pollack, Scott, Pan, Meng, Singer, Monica, Matheis, Michele, Murray, William, Cavender, Druie, Wachter, Michael
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
Get full text
Journal Article
A Novel Carbohydrate-Glycosphingolipid Interaction between a β-(1–3)-Glucan Immunomodulator, PGG-glucan, and Lactosylceramide of Human Leukocytes
Zimmerman, Janet W., Lindermuth, Johanna, Fish, Pamela A., Palace, Gerard P., Stevenson, Tom T., DeMong, Duane E.
Published in The Journal of biological chemistry (21.08.1998)
Published in The Journal of biological chemistry (21.08.1998)
Get full text
Journal Article
Substituted dipiperidine alcohols as potent CCR2 antagonists
Xia, Mingde, Hou, Cuifen, DeMong, Duane, Pollack, Scott, Pan, Meng, Brackley, James, Singer, Monica, Matheis, Michele, Cavender, Druie, Wachter, Michael
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
Get full text
Journal Article