Antifungal activity of a series of 1,2-benzisothiazol-3(2 H)-one derivatives
Dou, Dengfeng, Alex, Deepu, Du, Bingfan, Tiew, Kok-Chuan, Aravapalli, Sridhar, Mandadapu, Sivakoteswara Rao, Calderone, Richard, Groutas, William C.
Published in Bioorganic & medicinal chemistry (01.10.2011)
Published in Bioorganic & medicinal chemistry (01.10.2011)
Get full text
Journal Article
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors
Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moyer, Bryan D., Peterson, Emily A., Roberts, John, Yu, Violeta L., Weiss, Matthew M.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Get full text
Journal Article
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement
Marx, Isaac E, Dineen, Thomas A, Able, Jessica, Bode, Christiane, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Du, Bingfan, Foti, Robert S, Fremeau, Robert T, Gao, Hua, Gunaydin, Hakan, Hall, Brian E, Huang, Liyue, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Lin, Min-Hwa Jasmine, Liu, Dong, McDermott, Jeff S, Moyer, Bryan D, Peterson, Emily A, Roberts, Jonathan T, Rose, Paul, Wang, Jean, Youngblood, Beth D, Yu, Violeta, Weiss, Matthew M
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
Get full text
Journal Article
Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones
Nguyen, Hanh Nho, Cee, Victor J, Deak, Holly L, Du, Bingfan, Faber, Kathleen Panter, Gunaydin, Hakan, Hodous, Brian L, Hollis, Steven L, Krolikowski, Paul H, Olivieri, Philip R, Patel, Vinod F, Romero, Karina, Schenkel, Laurie B, Geuns-Meyer, Stephanie D
Published in Journal of organic chemistry (20.04.2012)
Published in Journal of organic chemistry (20.04.2012)
Get full text
Journal Article
785 STING-agonist ADCs targeting tumor-associated antigens coordinate immune-mediated killing of antigen-negative cancer cells
Wongthida, Phonphimon, Catcott, Kalli, Lancaster, Kelly, Bentley, Keith, Dirksen, Anouk, Du, Bingfan, Eitas, Timothy, Kelleher, Eugene, Malli, Naniye, Mosher, Rebecca, Protopopova, Marina, Shaw, Pamela, Stevenson, Cheri, Thomas, Joshua, Uttard, Alex, Duvall, Jeremy, Toader, Dorin, Damelin, Marc, Bukhalid, Raghida, Lowinger, Timothy
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
Get full text
Journal Article
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists
Nguyen, Hanh Nho, Bregman, Howie, Buchanan, John L., Du, Bingfan, Feric, Elma, Huang, Liyue, Li, Xingwen, Ligutti, Joseph, Liu, Dong, Malmberg, Annika B., Matson, David J., McDermott, Jeff S., Patel, Vinod F., Wilenkin, Ben, Zou, Anruo, McDonough, Stefan I., DiMauro, Erin F.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Get full text
Journal Article
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists
Chakka, Nagasree, Bregman, Howie, Du, Bingfan, Nguyen, Hanh Nho, Buchanan, John L., Feric, Elma, Ligutti, Joseph, Liu, Dong, McDermott, Jeff S., Zou, Anruo, McDonough, Stefan I., DiMauro, Erin F.
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Get full text
Journal Article
Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer
Toader, Dorin, Fessler, Shawn P, Collins, Scott D, Conlon, Patrick R, Bollu, Reddy, Catcott, Kalli C, Chin, Chen-Ni, Dirksen, Anouk, Du, Bingfan, Duvall, Jeremy R, Higgins, Stacy, Kozytska, Mariya V, Bellovoda, Kamela, Faircloth, Chelsey, Lee, David, Li, Fu, Qin, Liuliang, Routhier, Caitlin, Shaw, Pamela, Stevenson, Cheri A, Wang, Jason, Wongthida, Phonphimon, Ter-Ovanesyan, Elena, Ditty, Elizabeth, Bradley, Stephen P, Xu, Ling, Yin, Mao, Yurkovetskiy, Aleksandr V, Mosher, Rebecca, Damelin, Marc, Lowinger, Timothy B
Published in Molecular cancer therapeutics (01.09.2023)
Published in Molecular cancer therapeutics (01.09.2023)
Get full text
Journal Article
Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios
Clardy, Susan M, Uttard, Alex, Du, Bingfan, Catcott, Kalli C, Lancaster, Kelly L, Ditty, Elizabeth, Sadowsky, Jack, Zurita, Jeffrey, Malli, Naniye, Qin, LiuLiang, Bradley, Stephen P, Avocetien, Kenneth, Carter, Tyler, Kim, Dokyong, Nazzaro, Mark, Xu, Ling, Pillow, Thomas H, Zacharias, Neelie T, Lewis, Gail D, Rowntree, Rebecca K, Iyengar, Radha, Lee, David H, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B
Published in Molecular cancer therapeutics (03.01.2024)
Published in Molecular cancer therapeutics (03.01.2024)
Get full text
Journal Article
Abstract 907: XMT-1660, a B7-H4-targeted Dolasynthen antibody-drug conjugate for the treatment of breast cancer
Fessler, Shawn P., Wang, Jason, Collins, Scott D., Qin, LiuLiang, Avocetien, Kenneth, Xu, Ling, Eydelloth, Ronald, Vonderfecht, Steven, Chin, Chen-Ni, Bradley, Steven, Clardy, Susan, Dirksen, Anouk, Ditty, Elizabeth, Du, Bingfan, Kim, Dokyong, Mosher, Rebecca, Ter-Ovanesyen, Elena, Slocum, Kelly, Uttard, Alex, Wongthida, Phonphimon, Zurita, Jeffrey, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract P167: Site-specific Dolasynthen ADCs demonstrate consistent exposure across a wide range of drug-to-antibody ratios
Catcott, Kalli C., Clardy, Susan, Sadowsky, Jack, Rowntree, Rebecca K., Centibas, Naniye Malli, Xu, Ling, Polson, Andy, Avocetien, Kenneth, Carter, Tyler, Nazzaro, Mark, Kim, Dokyong "DK", Pillow, Thomas H., Zacharias, Neelie, Wu, Cong, Zurita, Jeffrey, Ditty, Elizabeth, Bradley, Stephen, Uttard, Alex, Du, Bingfan, Sawyer, William S., Leipold, Doug, Phillips, Gail Lewis, Qin, LiuLiang, Slocum, Kelly, Rosario, Geoffrey Del, Li, Ginny, Yu, Shang-Fan, Lee, David, Iyengar, Radha, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
Get full text
Journal Article
Abstract 2894: XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma
Fessler, Shawn, Dirksen, Anouk, Collins, Scott D., Xu, Ling, Lee, Winnie, Wang, Jason, Eydelloth, Ron, Ter-Ovanesyen, Elena, Zurita, Jeffrey, Ditty, Elizabeth, Nehilla, Barrett, Clardy, Susan, Carter, Tyler, Avocetien, Kenneth, Nazzaro, Mark, Le, Nam, Catcott, Kalli C., Uttard, Alex, Du, Bingfan, Chin, Chen-Ni, Mosher, Rebecca, Slocum, Kelly, Qin, Liuliang, Lee, David, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Discovery of N‑(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines
Geuns-Meyer, Stephanie, Cee, Victor J, Deak, Holly L, Du, Bingfan, Hodous, Brian L, Nguyen, Hanh Nho, Olivieri, Philip R, Schenkel, Laurie B, Vaida, Karina R, Andrews, Paul, Bak, Annette, Be, Xuhai, Beltran, Pedro J, Bush, Tammy L, Chaves, Mary K, Chung, Grace, Dai, Yang, Eden, Patrick, Hanestad, Kelly, Huang, Liyue, Lin, Min-Hwa Jasmine, Tang, Jin, Ziegler, Beth, Radinsky, Robert, Kendall, Richard, Patel, Vinod F, Payton, Marc
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
Get full text
Journal Article
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement
La, Daniel S., Peterson, Emily A., Bode, Christiane, Boezio, Alessandro A., Bregman, Howard, Chu-Moyer, Margaret Y., Coats, James, DiMauro, Erin F., Dineen, Thomas A., Du, Bingfan, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Fremeau, Robert, Huang, Xin, Ilch, Christopher, Kornecook, Thomas J., Kreiman, Charles, Ligutti, Joseph, Jasmine Lin, Min-Hwa, McDermott, Jeff S., Marx, Isaac, Matson, David J., McDonough, Stefan I., Moyer, Bryan D., Nho Nguyen, Hanh, Taborn, Kristin, Yu, Violeta, Weiss, Matthew M.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Get full text
Journal Article
Discovery of a biarylamide series of potent, state-dependent Na(V)1.7 inhibitors
Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moyer, Bryan D., Peterson, Emily A., Roberts, John, Yu, Violeta L., Weiss, Matthew M.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Get full text
Journal Article
Sulfonamides as Selective Na(v)1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement
Marx, Isaac E., Dineen, Thomas A., Able, Jessica, Bode, Christiane, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F., Du, Bingfan, Foti, Robert S., Fremeau, Robert T., Gao, Hua, Gunaydin, Hakan, Hall, Brian E., Huang, Liyue, Kornecook, Thomas, Kreiman, Charles R., La, Daniel S., Ligutti, Joseph, Ling, Min-Hwa Jasmine, Liu, Dong, McDermott, Jeff S., Moyer, Bryan D., Peterson, Emily A., Roberts, Jonathan T., Rose, Paul, Wang, Jean, Youngblood, Beth D., Yu, Violeta, Weiss, Matthew M.
Published in ACS medicinal chemistry letters (01.12.2016)
Published in ACS medicinal chemistry letters (01.12.2016)
Get full text
Journal Article
Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain
Bregman, Howard, Berry, Loren, Buchanan, John L, Chen, April, Du, Bingfan, Feric, Elma, Hierl, Markus, Huang, Liyue, Immke, David, Janosky, Brett, Johnson, Danielle, Li, Xingwen, Ligutti, Joseph, Liu, Dong, Malmberg, Annika, Matson, David, McDermott, Jeff, Miu, Peter, Nguyen, Hanh Nho, Patel, Vinod F, Waldon, Daniel, Wilenkin, Ben, Zheng, Xiao Mei, Zou, Anruo, McDonough, Stefan I, DiMauro, Erin F
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
Get full text
Journal Article
Abstract 2114: Tumor cell-targeted STING-agonist antibody-drug conjugates achieve potent anti-tumor activity by delivering STING agonist specifically to tumor cells andFcγRI-expressing subset of myeloid cells
Cetinbas, Naniye Malli, Catcott, Kalli C., Monnell, Travis, Soomer-James, Jahna, Bentley, Keith, Clardy, Susan, Du, Bingfan, Kelleher, Eoin, Protopopova, Marina, Stevenson, Cheri, Thomas, Joshua D., Uttard, Alex, Toader, Dorin, Duvall, Jeremy, Bukhalid, Raghida, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab
Duvall, Jeremy R., Bukhalid, Raghida A., Cetinbas, Naniye M., Catcott, Kalli C., Lancaster, Kelly, Bentley, Keith W., Clark, Suzanna, Clardy, Susan, Collins, Scott D., Dirksen, Anouk, Ditty, Elizabeth, Du, Bingfan, Kelleher, Eugene W., Monnell, Travis, Protopopova, Marina, Routhier, Caitlin, Stevenson, Cheri, Ter-Ovanesyan, Elena, Thomas, Joshua D., Uttard, Alex, Wang, Jason, Wongthida, Phonphimon, Xu, Ling, Yau, Annika, Zurita, Jeffrey, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists
Chakka, Nagasree, Bregman, Howie, Du, Bingfan, Nguyen, Hanh Nho, Buchanan, John L, Feric, Elma, Ligutti, Joseph, Liu, Dong, McDermott, Jeff S, Zou, Anruo, McDonough, Stefan I, Dimauro, Erin F
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Get full text
Journal Article