Search Results - "DRUG METABOLISM AND PHARMACOKINETICS" :: K.UTB vyhledávací portál

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Review of finalized ICH M12 guideline on drug interaction studies

by Ishiguro, Akihiro
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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How will CYP induction related PBPK applications be evaluated during the NDA reviews?

by Wang, Ying-Hong
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Metabolite profiling of [14C]BMS-986166 and its active metabolite (BMS-986166-P) following a single oral dose to intact/bile duct cannulated rats

by Chen, Weiqi, Lecureux, Lloyd, Li, Wenying
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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ABCC4 genetic polymorphism may indirectly regulate disposition of capecitabine metabolite in colorectal cancer patients

by Masuo, Yusuke, Matsumoto, Natsumi, Oishi, Ayano, Ikeda, Yui, Fujita, Ken-ichi, Kato, Yukio
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Metabolism of zastaprazan in human and animal hepatocytes

by Lee, Min Seo, Kim, John, Cha, Hyunju, Cheon, Banyoon, Song, Im-Sook, Lee, Hye Suk
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Confirmation of albumin-mediated effect on organic anion transporter 1/3 and its improvement to prediction of renal clearance

by Feng Tan, Shawn Pei, Tillmann, Annika, Murby, Susan, Rostami-Hodjegan, Amin, Scotcher, Daniel, Galetin, Aleksandra
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Influence of buffer composition on parameterization of liver and kidney scaling factors in rats and mice

by Doerksen, Michael, Jones, Robert, Coughtrie, Michael, Collier, Abby
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Population pharmacokinetics of ceftriaxone in Japanese patients with hemodialysis

by Tohi, Makiko, Hotta, Takumi, Nishioka, Hiroaki, Fukushima, Keizo, Hashida, Tohru, Sugioka, Nobuyuki, Muroi, Nobuyuki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes epigenetic effects: Possible mechanism based on whole-genome methylation analysis

by Fujimoto, Mana, Sano, Hiroe, Li, Ren-shi, Chen, Hong-bin, Koga, Takayuki, Tanaka, Yoshitaka, Ishii, Yuji
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Developing natural products as potential therapeutic agents

by Soumyanath, Amala
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Assessment of integrated strategy for prodrug metabolic transformation in plasma: Statistical and analytical

by Wang, Wei, Aoyama, Ron, Yue, Qin, Soohoo, Daniel, Murray, Bernard
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Effect of the hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat on expression of breast cancer resistance protein (BCRP/ABCG2) in human kidney epithelial cell line HK-2

by Nagai, Junya, Yamazaki, Makiko, Takahashi, Ai, Urakami-Takebayashi, Yumiko, Ohno, Yoshio, Motohashi, Hideyuki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Evaluation of a cinnamomum verum product on the pharmacokinetics of the CYP2A6 model drugs nicotine and letrozole in healthy adults

by Nguyen, Aiden-Hung, Cherel, Maxey, Cope, Vixen, Hadi, Deena, Manwill, Preston, Cech, Nadja, Thummel, Kenneth, Paine, Mary
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Selection of liver models of hepatic drug clearance: Improvements and implications for ivive and PBPK modeling

by Pang, K. Sandy, Lu, Weijia Ivy, Mulder, Gerard
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Pharmacokinetic and pharmacodynamic interactions between astragalus membranaceus polysaccharides and metformin in diabetic mice

by Zuo, Zhong, Song, Qianbo, Zou, Junju, Shaw, Pang Chui
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Characterization of age-dependent abundance of drug transporter proteins and conjugating enzymes in human hepatocytes: Implication for pediatric drug dosing

by Thakur, Aarzoo, Subash, Sandhya, Ahire, Deepak, Prasad, Bhagwat
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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An improved sample preparation and analysis procedure for estradiol LC-MS/MS quantification

by Johns, Michael, Tsivkovski, Oleg, Coutinho, Eulalia, Dalvie, Deepak, Fowler, Melissa, Markison, Stacy
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Exceeding 100% bioavailability in dog PK: Implication of CYP2D15 polymorphism

by Zang, Richard, Shi, Jianxia, Jain, Jay, Li, Austin
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Global proteomic profiling of a patient-derived 3D CYST model and reference tissue of polycystic kidney disease

by Meyer, Alina, Khalil, Bola, Iljin, Margarita, Bange, Hester, Price, Leo, Peters, Dorien, Artursson, Per
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Effects of mefenamic acid on the conjugative metabolism of indole and p-cresol in relation to cellular necrosis in a metabolically competent human hepatoma cell line

by Kiang, Tony, Al-Dajani, Ala’a
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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