Search Results - "DRUG METABOLISM AND PHARMACOKINETICS" :: K.UTB vyhledávací portál

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Screening methods comparison of the effect of pharmaceutical excipients on drug permeability

by Morita, Tokio, Yoshida, Hiroyuki, Tomita, Naomi, Sato, Yoji
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Utilizing PBPK modeling and in vitro data for predicting complex DDIS of OATP1B and CYP substrates caused by various perpetrators

by Sugiyama, Yuichi
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Utilizing patient-derived tumoroids as a screening platform for evaluating cell- based immunotherapies in solid tumors

by Wallace, Gillian, Yang, Xiaoyu (Jenny), Steinitz, Lindsay Bailey, Mafreshi, Maryam, Delgadillo, Jacob, Wong, Garrett, Chandra, Vivek, Paul, Colin, Yankaskas, Chris, Balhouse, Brittany, Sharp, Jason, Dallas, Matt
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Identification of a novel OATP2B1 substrate by a docking study using AlphaFold2 structure

by Matsuda, Runa, Nishimura, Tomohiro, Tomi, Masatoshi, Noguchi, Saki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Mass balance recovery, absorption, metabolism and excretion of [14C]-Acoziborole in healthy male subjects after single oral dosing - II - mass balance and clinical safety assessments

by Shaw, Iain, Sidhu, Sharan, Remby, Sandra, Gillon, Jean-Yves, Simon, François, Tarral, Antoine, van Andel, Lotte, Vaes, Wouter
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Impact of N-acetyltransferase (NAT) genetic polymorphisms on NAT catalytic activity in human colon mucosa

by Massey, Thomas, King, Will, Ho, Vikki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Industrial perspective of reactive metabolites: When to be afraid and when to be very afraid

by Bauman, Jonathan
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Characterization of 14C-Eltanexor metabolism and disposition in rats

by Fan, Rong, Benayoud, Farid, Kotreka, Udai, Kye, Steve, Gudi, Girish
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Mucoadhesive hemi-porous Janus microparticles: Potential formulation to improve intestinal absorption for BCS Class 3 drugs

by Matsumoto, Akihiro, Murao, Satoshi, Maki, Syou, Kaneda, Masayuki, Kitazawa, Takeo, Takashima, Tomoya, Murakami, Masahiro
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Investigation of OATP1B inhibitory effect by a cyclic peptide using an endogenous biomarker coproporphyrin-I in monkeys

by Watari, Ryosuke, Sawada, Hiromi, Mayumi, Kei
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture

by Zhang, Suhong, Koppara, Samuel
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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In vitro - In vivo extrapolation approaches for glucuronidated drugs: Promises and pitfalls

by Miners, John O.
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Challenges and opportunities for improved prediction of CNS penetration across species using MDR1-overexpressing cells

by Sóskuti, Emőka, Szilvásy, Nóra, Temesszentandrási-Ambrus, Csilla, Urbán, Zoltán, Csíkvári, Olivér, Szabó, Zoltán, Kecskeméti, Gábor, Pusztai, Éva, Gáborik, Zsuzsanna
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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High impact application of a continuous learn and confirm PBPK modeling strategy: Evaluating the drug-drug interaction potential for a transglutaminase-2 inhibitor

by Mudunuru, Jennypher, Salem, Farzaneh, Thomson, Debbie, Uings, Iain, Taskar, Kunal
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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In vitro liver models for toxicological research

by Fukunaga, Ichiro, Takebe, Takanori
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach

by Bachhav, Namrata, Prasad, Bhagwat
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Monkey blood-brain barrier co-culture model as an alternative method for predicting brain penetration

by Kanki, Satomi
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Liver humanized chimeric PXB-MOUSE® as a model to predict human renal toxicity by aldehyde oxidase dependent metabolism of SGX-523

by Johnson, Kevin, Hutzler, Matt, Long, Kelly, Markovits, Judit, Touchette, Erin, Cooper, Joshua, Aulbach, Adam, Jones, Langston
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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The impact of glucose levels on efficacy of the FDA-approved antisense oligonucleotide drugs

by Giang Nguyen, Le Tra
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Antisense oligonucleotides’ metabolite identification using hydrophilic interaction liquid chromatography—High resolution mass spectrometry: Application for non-human primate study samples of tofersen

by Liu, Ying, Post, Noah, Gu, Chungang (Chuck)
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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