Search Results - "DRUG METABOLISM AND PHARMACOKINETICS" :: K.UTB vyhledávací portál

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Investigating the influence of CYP3A and CYP2C8 phenotypes on tucatinib clearance in a diverse cohort of human hepatocyte donors

by Latham, Bethany, Jackson, Klarissa, Montazeri, Pegah
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Change in transport function of drugs into the multicellular inner blood-retinal barrier spheroids under hypoxic culture with advanced glycation end-products

by Akanuma, Shin-ichi, Yoshisaki, Misa, Tega, Yuma, Hosoya, Ken-ichi
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Assess CYP450 induction by qRT-PCR quantificaiton of CYP450 mRNAs from Small Extracellular Vesicles (SEVS) derived from plasma

by Xu, Shengjie, Achour, Brahim, Gibson, Christopher, Wang, Weixun, Spellman, Daniel, Zhang, Rena
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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The gut microbiome regulates hepatic drug processing genes in livers of humanized PXR-CAR-CYP3A4/3A7 mice

by Liem, Jennifer, Lim, Joe, Chen, Xin, Cui, Julia, Mao, Qingcheng, Lin, Yvonne
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Quantitative analysis of gastrointestinal drug absorption and disposition using state-of-the-art technology

by Shirasaka, Yoshiyuki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Quantitative analysis of the impact of C421A mutation on BCRP activity in human ileal CRYPT-derived differentiated cells

by Namai, Mana, Hashimoto, Yoshiki, Michiba, Kazuyoshi, Shimomura, Osamu, Miyazaki, Yoshihiro, Hashimoto, Shinji, Ohara, Yusuke, Enomoto, Tsuyoshi, Oda, Tatsuya, Kazuya, Maeda, Kusuhara, Hiroyuki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Xenobiotic transporter SLC22A4 expressed in microglia and neuron as a potential target for neurogenesis in Alzheimer's disease model mice

by Yamashita, Reiya, Ishimoto, Takahiro, Masuo, Yusuke, Sasaguri, Hiroki, Saito, Takashi, Saido, Takaomi, Kato, Yukio
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Role of intestinal transporters in regional absorption kinetics and intricate pharmacokinetic profiles of talinolol

by Ishida, Kazuya, Liang, Xiaomin, Buyukozturk, Fulden, Hao, Jia, Wan, Christine, Lai, Yurong
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Identification and characterization of phase II metabolites of resolvins D1 and D5

by Nogueira, Marina, Sanchez, Stephanie, Amin, Warda, Thomas, Sarah, Yang, Gong, Milne, Ginger
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Development of an in vitro Metabolic Dysfunction-Associated Steatohepatitis (MASH) model to study hepatic transporters

by Kyburz, Sarina, Murphy, William A., Kralj, Thomas, Fallon, John K., Tiley, Jacqueline B., Brouwer, Kim L.R.
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Unraveling the impact of metabolic dysfunction-associated steatohepatitis on the therapeutic efficacy of FDA-approved siRNA drugs

by Tawfik, Sherouk, Giang Nguyen, Le Tra, Jin, Jing, Armanios, Beshoy, Zhong, Xiao-bo
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Functional characterization of ATP13A3 as a plasma membrane polyamine transporter

by Morimoto, Haruka, Ishihara, Takuma, Yasujima, Tomoya, Yamashiro, Takahiro, Yuasa, Hiroaki
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Drug-drug interaction studies of cortisol in cynomolgus monkeys by measuring cortisol, cortisol-D4, and their 6β-hydroxymetabolites in plasma

by Nakanishi, Yasuharu, Nishimura, Yuki, Aikawa, Taiki, Tanaka, Fumi, Nakamura, Takatoshi, Utoh, Masahiro
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Influence of the genetic polymorphism of CYP2D1 on metabolism and pharmacokinetics of E2027 in rats

by Kasamori, Nana, Yamamoto, Masae, Mochizuki, Toshiki, Sagane, Koji, Nagaya, Yoko, Nakatani, Yosuke, Nozaki, Yoshitane
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range

by Enoru, Julius, Joshi, Anand, Natarajan, Paramasivam, Jones, Mira, Sarvaiya, Hetal, Keller, Steve
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Species-specific plasma matrix matching for mist coverage determination

by Freiberger, Elyse, Underwood, Essence, Thompson, Michael, Wagner, David
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Unexpected major circulating metabolite M219 detected in 14C-labeled human adme study of brilaroxazine

by Shen, Li, Fan, Yanfeng, Bhat, Laxminarayan, Bhat, Seema, Kulanthaivel, Palaniappan, Mutlib, Abdul
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Production and use of recombinant mirnas to dissect the intrinsic differences in miRNA biogenesis and regulation of drug metabolism and disposition

by Tu, Meijuan, Wang, Yimei, Yu, Aiming, Batra, Neelu
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Development of an in vitro platform for screening UGT inhibitors using human liver microsomes

by Jiang, Lifang, Kan, Yating, Liu, Xi, Ma, Hongying, Tao, Yi, Shen, Liang, Chen, Genfu
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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An evaluation of CYP and non-CYP reaction phenotyping study trends from 2000-2023: A cro perspective

by Mueller, Tina, Bohl, Christopher, Taylor, Andrew, Noah, Courtney, Ogilvie, Brian
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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