Search Results - "DRUG METABOLISM AND PHARMACOKINETICS" :: K.UTB vyhledávací portál

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Converting suspension-type human primary hepatocytes to be plateable-type for use as an in vitro pharmacokinetics model

by Shahin, Raghda, Sakai, Yoko, Shirai, Kotaro, Hashita, Tadahiro, Matsunaga, Tamihide, Iwao, Takahiro
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Investigation of an OATP1B inhibitory effect by a cyclic peptide using the endogenous biomarker coproporphyrin-I in monkeys

by Sawada, Hiromi, Kido, Yasuto, Iwasaki, Makoto, Nishida, Kimiko, Mayumi, Kei, Watari, Ryosuke
Published in Drug metabolism and pharmacokinetics (01.08.2025)

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Construction of refined CYP2D6-Template system for studies of its metabolism and inhibition

by Yamazoe, Yasushi, Murayama, Norie, Yoshinari, Kouichi
Published in Drug metabolism and pharmacokinetics (01.08.2025)

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Continuous exposure to therapeutic drugs doxorubicin and vincristine reduces drug efficacy through transcriptional and post-transcriptional regulation of P-glycoprotein in follicular lymphoma

by Yano, Kentaro, Iwase, Yumiko, Ogihara, Takuo, Kuwabara, Takashi
Published in Drug metabolism and pharmacokinetics (01.08.2025)

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Human brain organoids for understanding substance use disorders

by Li, Kangle, Gu, Longjun, Cai, Hongwei, Lu, Hui-Chen, Mackie, Ken, Guo, Feng
Published in Drug metabolism and pharmacokinetics (01.10.2024)

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Impact of degradation in subcutaneous tissue and lymphatic fluid on absorption of Fc-fusion proteins following subcutaneous administration

by Yokoyama, Miki, Suzuki, Eiko, Nakai, Daisuke
Published in Drug metabolism and pharmacokinetics (01.07.2025)

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In vitro hydrolysis of areca nut xenobiotics in human liver

by Paolillo, Vincenzo, Jayakumar, Mahendran, Sheperd, Colton, Tran, Andrew, Hoang, Stephanie, Dao, Nhu, Jain, Parag, Myers, Alan L.
Published in Drug metabolism and pharmacokinetics (01.02.2025)

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Substrate inhibition potential of arachidonic acid on 14,15-epoxidation, a biological drug developmental target, mediated by recombinant human cytochrome P450 2J2 and 2C8 enzymes

by Kojima, Ayaka, Nadai, Masayuki, Yamazaki, Hiroshi, Katoh, Miki
Published in Drug metabolism and pharmacokinetics (01.04.2025)

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Establishment of an air-liquid interface intestinal organoid monolayer and its characterization for drug absorption and metabolism

by Wehl, Ilona, Walser, Veronika, Beck, Stefan, Geigner, Stefanie, Mueller, Juergen, Damme, Katja, Schreck, Ilona
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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First-in-human dose estimation for a new composition bee venom, a candidate drug of Alzheimer disease, based on pharmacokinetic interspecies allometric scaling from mice, rats, and beagle dogs

by Kim, Da Hyun, Chae, Soon Uk, Jo, Seong Jun, Kim, Duk Yeon, Lee, Sangyoung, Lee, Chae Bin, Min, Jee Sun, Bae, Soo Kyung
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Hepash cells, a novel platform to assess the clearance of low metabolic turnover compounds and CYP induction

by Tsuruta, Satoshi, Nakagawa, Toshito, Kawai, Shigeto, Yamada, Mimori, Tanno, Honoka, Shimojo, Tomofumi, Nakano, Kiyotaka, Tachibana, Tatsuhiko
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Application of enteroid monolayers to evaluate potential pharmacokinetic oregano oil-drug interactions

by O'Mahony, Eimear, Arian, Christopher, Kelly, Edward, Paine, Mary, Thummel, Kenneth
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Assessment of unintentional effects on endangered species endemic to the Bonin Islands caused by deployment of anticoagulant rodenticide

by Koide, Masashi, Kawai, Yusuke, Kondo, Mitsuki, Odaya, Yoshiya, Horikoshi, Kazuo, Suzuki, Hajime, Nagamine, Takashi, Nakaya, Yumiko, Ikenaka, Yoshinori, Ishizuka, Mayumi, Nakayama, Shouta
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation

by Cech, Nadja
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Gastrointestinal imaging with MRI: Insights into the behavior of dosage forms and the conditions at the site of drug release

by Weitschies, Werner
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Functional identification of a lysosomal transporter SLC46A3 as a novel glycoside transporter

by Tomabechi, Ryuto, Watanabe, Mitsuki, Saito, Naoki, Saito, Daisuke, Kishimoto, Hisanao, Higuchi, Kei, Kazuya, Maeda, Inoue, Katsuhisa
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – I – Preparation of GMP [14C]- acoziborole drug substance

by Carver, David, Cousin, Peggy, Shaw, Iain, Remby, Sandra, Gillon, Jean-Yves, Robinson, Stephen
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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PM2.5 engages impairment of mucosal immunity, involving alteration of complement activation and cell junction assembly by regulated IL-17 levels: Pathological and proteomic approaches

by Palpai, Warat, Tansrivorarat, Thamradee, Moonwiriyakit, Aekkacha, Chiangjong, Wararat
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Buffer compositions strongly impact the in vitro assessment of CYP fraction metabolized using human liver microsomes or expressed isoenzymes

by Tamemoto, Yuta, Shibata, Yukihiro, Hashimoto, Natsumi, Yoshitomo, Aoi, Hozuki, Shizuka, Takahashi, Keita, Kumemura, Hana, Hatakeyama, Hiroto, Sato, Hiromi, Hisaka, Akihiro
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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Effect of substrates and inhibitors of breast cancer resistance protein on apixaban and rivaroxaban pharmacokinetics in Japanese patients

by Ueshima, Satoshi, Hira, Daiki, Matsuda, Sayana, Tabuchi, Yohei, Isono, Tetsuichiro, Ozawa, Tomoya, Itoh, Hideki, Morita, Shin-ya, Nakagawa, Yoshihisa, Horie, Minoru, Terada, Tomohiro, Katsura, Toshiya
Published in Drug metabolism and pharmacokinetics (01.06.2025)

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