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Intestinal secretion is potentially an important clearance mechanism for highly plasma-bound and low metabolic clearance efflux substrates
Subramanian, Murali, Ahire, Deepak, Tanna, Rakshit, Yu, Josh, Wang, Kelly, Wang, Wei, Smith, Gillian, Liu, Xingrong
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Protective effects of omeprazole against oxaliplatin-induced peripheral neuropathy via OCTN transporter-mediated mechanisms in a rodent model
Tsukushi, Yasuhito, Kobuchi, Shinji, Ito, Yukako, Sakaeda, Toshiyuki
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Impact of tyrosine kinases and inhibitors on SGLT1 activity
Kharve, Kshitee Sandeep, Shroff, Aayush, Cao, Jeiyun, Pasquariello, Kyle
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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A rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying the metabolites of seven major probe substrates in human liver microsomes
Li, Xiaotong, Zhu, Chunli, Wen, Xinxin, Li, Zhiyu, Jiang, Lifang, Xing, Lili, Tao, Yi, Shen, Liang
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Alteration in intercellular lipid composition of stratum corneum in Goto-Kakizaki rats: A model of type 2 diabetes with an increased fentanyl release ratio from the transdermal formulation
Mizuno, Satoshi, Shimada, Tsutomu, Makihara, Hiroko, Tsukui, Kei, Fujita, Arimi, Takabayashi, Makiko, Kawakami, Takahiro, Hara, Yusuke, Tokudome, Yoshihiro, Akase, Tomoko, Sai, Yoshimichi
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Hepatic expression of drug metabolizing enzymes is altered by concomitant obesogenic lipids and alcohol in mice and human hepatic organoids
Dempsey, Joseph, Kang, Inkyung, Harkin, Julia, Bayen, Susovon, Abdirahim, Samiraa, Stevens, Kelly, Carr, Rotonya
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Identification of the major circulating metabolite of MYMD-1 and elucidation of the mechanism of clearance of MYMD-1 in humans. Role of aldehyde oxidase and CYP2A6
Kassahun, Kelem, Yu, Sean, Tiller, Philip, Brager, Jenna, Chapman, Christopher, Mutlib, Abdul
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Expression and functional analyses of the PK-related genes in differentiated intestinal epithelial cells derived from cryopreserved human intestinal mucosal epithelium (CHIM)
Nakamura, Keiichiro, Tomabechi, Ryuto, Maeda, Kazuya
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Physiologically based pharmacokinetic modeling of cannabidiol (CBD), Δ-9- tetrahydrocannabinol (THC), and their active metabolites in healthy adults after administration of CBD and THC by multiple routes
Zhou, Zhu, Qian, Lixuan, Zhang, Tao, Dinh, Jean, Paine, Mary
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Quantitative prediction of P-GP/CYP3A substrate drug absorption in humans using a monolayer model derived from intestinal organoids
Mochizuki, Tatsuki, Tanaka, Kai, Tachibana, Tatsuhiko, Suzuki, Yukiko, Baba, Shogo, Nakano, Kiyotaka, Uchimura, Kousuke, Miyayama, Takashi, Kato, Yasutaka, Terao, Kimio
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Development and qualification of an in vitro assay to determine target mediated internalization of TREM2 receptor specific antibodies for TMDD assessment
Kraft, Thomas, Bolender, Anna-Lena, Padamsey, Aman, Koller, Erich, Britschgi, Markus, Niewoehner, Jens, Grimm, Hans Peter
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Establishment of a novel in vitro assay system with CRYPT-derived differentiated intestinal cells to evaluate drug-induced gastrointestinal toxicity caused by the disruption of mucus layer
Fukada, Shota, Tomabechi, Ryuto, Kazuya, Maeda
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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Systematic evaluation of underlying models that improve purely in-silico high- throughput mechanistic PBPK predictions across species
Jones, Jeremy, Bachorz, Rafal, Miller, David, Lawless, Michael, Chupakhin, Vladimir, Fraczkiewicz, Robert
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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