Chemical optimization of Pneumocandin B0 and selection of the pre-clinical candidate Caspofungin
Balkovec, JM, Black, RM, Bouffard, FA, Dropinski, JF, Hammond, ML, Zambias, RA
Published in Planta Medica (01.07.2012)
Published in Planta Medica (01.07.2012)
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Conference Proceeding
Novel 2,3-Dihydrobenzofuran-2-carboxylic Acids: Highly Potent and Subtype-Selective PPARα Agonists with Potent Hypolipidemic Activity
Shi, Guo Q, Dropinski, James F, Zhang, Yong, Santini, Conrad, Sahoo, Soumya P, Berger, Joel P, MacNaul, Karen L, Zhou, Gaochao, Agrawal, Arun, Alvaro, Raul, Cai, Tian-quan, Hernandez, Melba, Wright, Samuel D, Moller, David E, Heck, James V, Meinke, Peter T
Published in Journal of medicinal chemistry (25.08.2005)
Published in Journal of medicinal chemistry (25.08.2005)
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Journal Article
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists
Dropinski, James F., Akiyama, Taro, Einstein, Monica, Habulihaz, Bahanu, Doebber, Tom, Berger, Joel P., Meinke, Peter T., Shi, Guo Q.
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Journal Article
Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
Shi, Guo Q, Dropinski, James F, McKeever, Brian M, Xu, Shihua, Becker, Joseph W, Berger, Joel P, MacNaul, Karen L, Elbrecht, Alex, Zhou, Gaochao, Doebber, Thomas W, Wang, Peiran, Chao, Yu-Sheng, Forrest, Mike, Heck, James V, Moller, David E, Jones, A. Brian
Published in Journal of medicinal chemistry (30.06.2005)
Published in Journal of medicinal chemistry (30.06.2005)
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Journal Article
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872)
BARTIZAL, K, GILL, C. J, BALKOVEC, J, ABRUZZO, G. K, FLATTERY, A. M, KONG, L, SCOTT, P. M, SMITH, J. G, LEIGHTON, C. E, BOUFFARD, A, DROPINSKI, J. F
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
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Journal Article
Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis
ABRUZZO, G. K, FLATTERY, A. M, KROPP, H, BARTIZAL, K, GILL, C. J, KONG, L, SMITH, J. G, PIKOUNIS, V. B, BALKOVEC, J. M, BOUFFARD, A. F, DROPINSKI, J. F, ROSEN, H
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
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Journal Article
Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872)
HAJDU, R, THOMPSON, R, SUNDELOF, J. G, PELAK, B. A, BOUFFARD, F. A, DROPINSKI, J. F, KROPP, H
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
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Journal Article
Efficacy of MK-991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii
POWLES, M. A, LIBERATOR, P, SCHMATZ, D, ANDERSON, J, KARKHANIS, Y, DROPINSKI, J. F, BOUFFARD, F. A, BALKOVEC, J. M, FUJIOKA, H, AIKAWA, M, MCFADDEN, D
Published in Antimicrobial agents and chemotherapy (01.08.1998)
Published in Antimicrobial agents and chemotherapy (01.08.1998)
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Journal Article
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NOVEL CATIONIC PNEUMOCANDIN B-O DERIVATIVES
BOUFFARD, FA, ZAMBIAS, RA, DROPINSKI, JF, BALKOVEC, JM, HAMMOND, ML, ABRUZZO, GK, BARTIZAL, KF, MARRINAN, JA, KURTZ, MB, MCFADDEN, DC, NOLLSTADT, KH, POWLES, MA, SCHMATZ, DM
Published in Journal of medicinal chemistry (21.01.1994)
Published in Journal of medicinal chemistry (21.01.1994)
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Journal Article
Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis
KURTZ, M. B, DOUGLAS, C, BOUFFARD, F. A, DROPINSKI, J. F, HAMMOND, M. L, ZAMBIAS, R. A, ABRUZZO, G, BARTIZAL, K, MCMANUS, O. B, GARCIA, M. L, MARRINAN, J, NOLLSTADT, K, ONISHI, J, DREIKORN, S, MILLIGAN, J, MANDALA, S, THOMPSON, J, BALKOVEC, J. M
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
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Journal Article
New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat
SCHMATZ, D. M, POWLES, M. A, MCFADDEN, D, NOLLSTADT, K, BOUFFARD, F. A, DROPINSKI, J. F, LIBERATOR, P, ANDERSEN, J
Published in Antimicrobial Agents and Chemotherapy (01.06.1995)
Published in Antimicrobial Agents and Chemotherapy (01.06.1995)
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Journal Article