Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Di Lello, Paola, Pastor, Richard, Murray, Jeremy M, Blake, Robert A, Cohen, Frederick, Crawford, Terry D, Drobnick, Joy, Drummond, Jason, Kategaya, Lorna, Kleinheinz, Tracy, Maurer, Till, Rougé, Lionel, Zhao, Xianrui, Wertz, Ingrid, Ndubaku, Chudi, Tsui, Vickie
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
Bryan, Marian C, Drobnick, Joy, Gobbi, Alberto, Kolesnikov, Aleksandr, Chen, Yongsheng, Rajapaksa, Naomi, Ndubaku, Chudi, Feng, Jianwen, Chang, Willy, Francis, Ross, Yu, Christine, Choo, Edna F, DeMent, Kevin, Ran, Yingqing, An, Le, Emson, Claire, Huang, Zhiyu, Sujatha-Bhaskar, Swathi, Brightbill, Hans, DiPasquale, Antonio, Maher, Jonathan, Wai, John, McKenzie, Brent S, Lupardus, Patrick J, Zarrin, Ali A, Kiefer, James R
Published in Journal of medicinal chemistry (11.07.2019)
Published in Journal of medicinal chemistry (11.07.2019)
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Journal Article
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Heffron, Timothy P, Ndubaku, Chudi O, Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G, Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G
Published in ACS medicinal chemistry letters (14.04.2016)
Published in ACS medicinal chemistry letters (14.04.2016)
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Journal Article
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
Rudolph, Joachim, Murray, Lesley J, Ndubaku, Chudi O, O’Brien, Thomas, Blackwood, Elizabeth, Wang, Weiru, Aliagas, Ignacio, Gazzard, Lewis, Crawford, James J, Drobnick, Joy, Lee, Wendy, Zhao, Xianrui, Hoeflich, Klaus P, Favor, David A, Dong, Ping, Zhang, Haiming, Heise, Christopher E, Oh, Angela, Ong, Christy C, La, Hank, Chakravarty, Paroma, Chan, Connie, Jakubiak, Diana, Epler, Jennifer, Ramaswamy, Sreemathy, Vega, Roxanne, Cain, Gary, Diaz, Dolores, Zhong, Yu
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Journal Article
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
Corzo, Cesar A, Varfolomeev, Eugene, Setiadi, A Francesca, Francis, Ross, Klabunde, Sha, Senger, Kate, Sujatha-Bhaskar, Swathi, Drobnick, Joy, Do, Steven, Suto, Eric, Huang, Zhiyu, Eastham-Anderson, Jeffrey, Katewa, Arna, Pang, Jodie, Domeyer, Melanie, Dela Cruz, Christopher, Paler-Martinez, Andres, Lau, Vivian W C, Hadadianpour, Azadeh, Ramirez-Carrozi, Vladimir, Sun, Yonglian, Bao, Katherine, Xu, Daqi, Hunley, Emily, Brightbill, Hans D, Warming, Soren, Roose-Girma, Merone, Wong, Alfred, Tam, Lucinda, Emson, Claire L, Crawford, James J, Young, Wendy B, Pappu, Rajita, McKenzie, Brent S, Asghari, Vida, Vucic, Domagoj, Hackney, Jason A, Austin, Cary D, Lee, Wyne P, Lekkerkerker, Annemarie, Ghilardi, Nico, Bryan, Marian C, Kiefer, James R, Townsend, Michael J, Zarrin, Ali A
Published in Science signaling (02.06.2020)
Published in Science signaling (02.06.2020)
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A chemoselective Reformatsky–Negishi approach to α-haloaryl esters
Wong, Brian, Linghu, Xin, Crawford, James J., Drobnick, Joy, Lee, Wendy, Zhang, Haiming
Published in Tetrahedron (18.02.2014)
Published in Tetrahedron (18.02.2014)
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Journal Article
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety
Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (31.10.2015)
Published in ACS medicinal chemistry letters (31.10.2015)
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Journal Article
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity
Rajapaksa, Naomi S, Gobbi, Alberto, Drobnick, Joy, Do, Steven, Kolesnikov, Aleksandr, Liang, Jun, Chen, Yongsheng, Sujatha-Bhaskar, Swathi, Huang, Zhiyu, Brightbill, Hans, Francis, Ross, Yu, Christine, Choo, Edna F, DeMent, Kevin, Ran, Yingqing, An, Le, Emson, Claire, Maher, Jonathan, Wai, John, McKenzie, Brent S, Lupardus, Patrick J, Zarrin, Ali A, Kiefer, James R, Bryan, Marian C
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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Journal Article
Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety
Ndubaku, Chudi O, Crawford, James J, Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M, Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E, Hoeflich, Klaus P, Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P, Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J, O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1
Gazzard, Lewis, Appleton, Brent, Chapman, Kerry, Chen, Huifen, Clark, Kevin, Drobnick, Joy, Goodacre, Simon, Halladay, Jason, Lyssikatos, Joseph, Schmidt, Stephen, Sideris, Steve, Wiesmann, Christian, Williams, Karen, Wu, Ping, Yen, Ivana, Malek, Shiva
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Journal Article
Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1
Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Michael, Gancia, Emanuela, Gill, Matthew, Goodacre, Simon, Halladay, Jason, Hewitt, Joanne, Hunt, Hazel, Kintz, Samuel, Lyssikatos, Joseph, Macleod, Calum, Major, Sarah, Médard, Guillaume, Narukulla, Raman, Ramiscal, Judi, Schmidt, Stephen, Seward, Eileen, Wiesmann, Christian, Wu, Ping, Yee, Sharon, Yen, Ivana, Malek, Shiva
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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Journal Article
Abstract B23: Crucial deubiquitinases in cancer cell survival
Kategaya, Lorna, Cuellar, Trinna, Haley, Ben, Liu, Jinfeng, Tran, Andy, Cao, Yi, Stokoe, David, McCleland, Mark, Blackwood, Beth, Yee, Sharon, Drobnick, Joy, Drummond, Jake, Ernst, James, Kwok, Michael, Ly, Cuong, Pastor, Richard, Lello, Paola Di, Ndubaku, Chudi, Blake, Robert, Tsui, Vickie, Murray, Jeremy, Maurer, Till, Wertz, Ingrid
Published in Clinical cancer research (01.01.2017)
Published in Clinical cancer research (01.01.2017)
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Journal Article
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis
Ndubaku, Chudi O, Crawford, Terry D, Chen, Huifen, Boggs, Jason W, Drobnick, Joy, Harris, Seth F, Jesudason, Rajiv, McNamara, Erin, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Vitorino, Philip, Wang, Lan, Wu, Ping, Yeung, Stacey, Chen, Jinhua, Chen, Kevin, Ding, Charles Z, Wang, Tao, Xu, Zijin, Gould, Stephen E, Murray, Lesley J, Ye, Weilan
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Journal Article
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar Moiety
Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
HPK1 억제제로서의 나프티리딘
CHAN BRYAN, WEI BINQING, LU AIJUN, WANG WEIRU, CARTWRIGHT MATTHEW W, LIANG JUN, HEFFRON TIMOTHY, FAVOR DAVID, DANIELS BLAKE, MADIN ANDREW, HU YONGHAN, MALHOTRA SUSHANT, ZHOU AIHE, GOOD ANDREW, TELLIS JOHN, DROBNICK JOY, SEWARD EILEEN, LAINCHBURY MICHAEL, HUESTIS MALCOLM, JONES GRAHAM, FONG KIN CHIU, SIU MICHAEL, RAJAPAKSA NAOMI, HU BAIHUA, GANCIA EMANUELA, MENDONCA ROHAN, STIVALA CRAIG, GAZZARD LEWIS
Year of Publication 09.12.2019
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Year of Publication 09.12.2019
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HPK1의 억제제인 이소퀴놀린
GOOD ANDREW, TELLIS JOHN, CHAN BRYAN, DROBNICK JOY, WEI BINQING, WANG WEIRU, SEWARD EILEEN, LAINCHBURY MICHAEL, CARTWRIGHT MATTHEW W, LIANG JUN, FONG KIN CHIU, HEFFRON TIMOTHY, FAVOR DAVID, RAJAPAKSA NAOMI, GANCIA EMANUELA, MENDONCA ROHAN, MADIN ANDREW, HU YONGHAN, MALHOTRA SUSHANT, STIVALA CRAIG, ZHOU AIHE, GAZZARD LEWIS
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
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1,7-DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER
DROBNICK JOY, MACLEOD CALUM, CHEN HUIFEN, LYSSIKATOS JOSEPH P, DYKE HAZEL JOAN, WILLIAMS KAREN, ELLWOOD CHARLES, GAZZARD LEWIS J, GOODACRE SIMON, KINTZ SAMUEL
Year of Publication 19.09.2012
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Year of Publication 19.09.2012
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Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Drobnick, Joy, Rajapaksa, Naomi S, Bryan, Marian C, Kolesnikov, Aleksandr, Kiefer, Jr., James Richard
Year of Publication 06.09.2022
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Year of Publication 06.09.2022
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BENZOFURANS AS IRAK4 MODULATORS
GOBBI, Alberto, KATSUMOTO, Tamiko, RAJAPAKSA, Naomi, BRYAN, Marian C, DROBNICK, Joy, KIEFER, James Richard
Year of Publication 27.04.2022
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Year of Publication 27.04.2022
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8-aminoisoquinoline compounds and uses thereof
Wang, Weiru, Liang, Jun, Drobnick, Joy, Choo, Edna F, Gazzard, Lewis J, Heffron, Timothy, Mendonca, Rohan V, Wei, BinQing, Chan, Bryan, Tellis, John, Siu, Michael
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
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