Ketopiperazine-based renin inhibitors: Optimization of the “C” ring
Holsworth, Daniel D., Cai, Cuiman, Cheng, Xue-Min, Cody, Wayne L., Downing, Dennis M., Erasga, Noe, Lee, Chitase, Powell, Noel A., Edmunds, Jeremy J., Stier, Michael, Jalaie, Mehran, Zhang, Erli, McConnell, Pat, Ryan, Michael J., Bryant, John, Li, Tingsheng, Kasani, Aparna, Hall, Eric, Subedi, Rajendra, Rahim, Mohammad, Maiti, Samarendra
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Discovery of novel non-peptidic ketopiperazine-based renin inhibitors
Holsworth, Daniel D., Powell, Noel A., Downing, Dennis M., Cai, Cuiman, Cody, Wayne L., Ryan, J. Michael, Ostroski, Robert, Jalaie, Mehran, Bryant, John W., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (01.04.2005)
Published in Bioorganic & medicinal chemistry (01.04.2005)
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Journal Article
The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents
Wright, Jon L, Caprathe, Bradley W, Downing, Dennis M, Glase, Shelly A, Heffner, Thomas G, Jaen, Juan C, Johnson, Stephen J, Kesten, Suzanne R, MacKenzie, Robert G
Published in Journal of medicinal chemistry (01.10.1994)
Published in Journal of medicinal chemistry (01.10.1994)
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Journal Article
Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo Amide−Epoxide Cyclization
Powell, Noel A, Ciske, Fred L, Clay, Emma C, Cody, Wayne L, Downing, Dennis M, Blazecka, Peter G, Holsworth, Daniel D, Edmunds, Jeremy J
Published in Organic letters (28.10.2004)
Published in Organic letters (28.10.2004)
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Journal Article
Identification, Characterization and Pharmacological Profile of Three Metabolites of (R)-(+)-1,2,3,6-Tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1-yl)methyl]p yridine (CI-1007), a Dopamine Autoreceptor Agonist and Potential Antipsychotic Agent
Wright, Jon L, Downing, Dennis M, Feng, M. Rose, Hayes, Roger N, Heffner, Thomas G, MacKenzie, Robert G, Meltzer, Leonard T, Pugsley, Thomas A, Wise, Lawrence D
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Journal Article
Inter-Intraphase Temperature Gradients in Fresh and Deactivated Catalyst Particles
Butt, John B, Downing, Dennis M, Lee, J. W
Published in Industrial & engineering chemistry fundamentals (01.05.1977)
Published in Industrial & engineering chemistry fundamentals (01.05.1977)
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Journal Article
Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo Amide-Epoxide Cyclization
Powell, Noel A., Ciske, Fred L., Clay, Emma C., Cody, Wayne L., Downing, Dennis M., Blazecka, Peter G., Holsworth, Daniel D., Edmunds, Jeremy J.
Published in ChemInform (08.02.2005)
Published in ChemInform (08.02.2005)
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Journal Article
Piperazine derivative renin inhibitors
POWELL NOEL AARON, DOWNING DENNIS M, HOLSWORTH DANIEL DALE, CLAY EMMA HAZEL, EDMUNDS JEREMY JOHN, CAI CUIMAN, LI TINGSHENG
Year of Publication 28.10.2004
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Year of Publication 28.10.2004
Patent
Benzimidazoles and imidazopyridines as central nervous system agents
JOHNSON; STEPHEN J, WISE; LAWRENCE D, WRIGHT; JONATHAN L, DOWNING; DENNIS M, GLASE; SHELLY A
Year of Publication 23.01.1996
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Year of Publication 23.01.1996
Patent