Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat
Sharma, Raman, Dowling, Matthew S., Futatsugi, Kentaro, Kalgutkar, Amit S.
Published in Chemical research in toxicology (19.06.2023)
Published in Chemical research in toxicology (19.06.2023)
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A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action
Dowling, Matthew B, Kumar, Rakesh, Keibler, Mark A, Hess, John R, Bochicchio, Grant V, Raghavan, Srinivasa R
Published in Biomaterials (01.05.2011)
Published in Biomaterials (01.05.2011)
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Foams with Enhanced Rheology for Stopping Bleeding
Choudhary, Hema, Rudy, Michael B, Dowling, Matthew B, Raghavan, Srinivasa R
Published in ACS applied materials & interfaces (31.03.2021)
Published in ACS applied materials & interfaces (31.03.2021)
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A comprehensive review of topical hemostatic agents: The good, the bad, and the novel
Tompeck, Allison J, Gajdhar, Aniq Ur Reham, Dowling, Matthew, Johnson, Steven B, Barie, Philip S, Winchell, Robert J, King, David, Scalea, Thomas M, Britt, L D, Narayan, Mayur
Published in The journal of trauma and acute care surgery (01.01.2020)
Published in The journal of trauma and acute care surgery (01.01.2020)
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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy
Cameron, Kimberly O, Kung, Daniel W, Kalgutkar, Amit S, Kurumbail, Ravi G, Miller, Russell, Salatto, Christopher T, Ward, Jessica, Withka, Jane M, Bhattacharya, Samit K, Boehm, Markus, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew, Caspers, Nicole L, Cokorinos, Emily, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Eng, Heather, Fernando, Dilinie P, Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R, Rose, Colin R, Ryder, Tim, Shavnya, Andre, Smith, Aaron C, Tu, Meihua, Wolford, Angela C, Xiao, Jun
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells
Mattheisen, Jordan M., Limberakis, Chris, Ruggeri, Roger B., Dowling, Matthew S., am Ende, Christopher W., Ceraudo, Emilie, Huber, Thomas, McClendon, Christopher L., Sakmar, Thomas P.
Published in Journal of the American Chemical Society (24.05.2023)
Published in Journal of the American Chemical Society (24.05.2023)
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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Futatsugi, Kentaro, Smith, Aaron C, Tu, Meihua, Raymer, Brian, Ahn, Kay, Coffey, Steven B, Dowling, Matthew S, Fernando, Dilinie P, Gutierrez, Jemy A, Huard, Kim, Jasti, Jayasankar, Kalgutkar, Amit S, Knafels, John D, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Ryder, Tim, Shavnya, Andre, Stock, Ingrid A, Tsai, Andy S, Tesz, Gregory J, Thuma, Benjamin A, Weng, Yan, Wisniewska, Hanna M, Xing, Gang, Zhou, Jun, Magee, Thomas V
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Journal Article
Hydrophobically-Modified Chitosan Gauze: A Novel Topical Hemostat
Chaturvedi, Apurva, Dowling, Matthew B., Ph.D, Gustin, John P., Ph.D, Scalea, Thomas M., M.D, Raghavan, Srinivasa R., Ph.D, Pasley, Jason D., D.O, Narayan, Mayur, M.D, M.P.H, M.B.A
Published in The Journal of surgical research (01.01.2017)
Published in The Journal of surgical research (01.01.2017)
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Journal Article
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3
Raux, Brigitt, Buchan, Karly A., Bennett, James, Christott, Thomas, Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Huber, Kilian V.M., Korczynska, Magdalena, Limberakis, Chris, Narayanan, Arjun, Owen, Dafydd R., Sáez, Laura Díaz, Stock, Ingrid A., Londregan, Allyn T.
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
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Journal Article
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Futatsugi, Kentaro, Cabral, Shawn, Kung, Daniel W., Huard, Kim, Lee, Esther, Boehm, Markus, Bauman, Jonathan, Clark, Ronald W., Coffey, Steven B., Crowley, Collin, Dechert-Schmitt, Anne-Marie, Dowling, Matthew S., Dullea, Robert, Gosset, James R., Kalgutkar, Amit S., Kou, Kou, Li, Qifang, Lian, Yajing, Loria, Paula M., Londregan, Allyn T., Niosi, Mark, Orozco, Christine, Pettersen, John C., Pfefferkorn, Jeffrey A., Polivkova, Jana, Ross, Trenton T., Sharma, Raman, Stock, Ingrid A., Tesz, Gregory, Wisniewska, Hanna, Goodwin, Bryan, Price, David A.
Published in Journal of medicinal chemistry (24.11.2022)
Published in Journal of medicinal chemistry (24.11.2022)
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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4
Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., Huber, Kilian, Korczynska, Magdalena, Lapham, Kimberly, Loria, Paula M., Narayanan, Arjun, Owen, Dafydd R., Raux, Brigitt, Sahasrabudhe, Parag V., Ruggeri, Roger B., Sáez, Laura Díaz, Stock, Ingrid A., Thuma, Benjamin A., Tsai, Andy, Varghese, Alison E.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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A chemical probe to modulate human GID4 Pro/N-degron interactions
Owens, Dominic D. G., Maitland, Matthew E. R., Khalili Yazdi, Aliakbar, Song, Xiaosheng, Reber, Viviane, Schwalm, Martin P., Machado, Raquel A. C., Bauer, Nicolas, Wang, Xu, Szewczyk, Magdalena M., Dong, Cheng, Dong, Aiping, Loppnau, Peter, Calabrese, Matthew F., Dowling, Matthew S., Lee, Jisun, Montgomery, Justin I., O’Connell, Thomas N., Subramanyam, Chakrapani, Wang, Feng, Adamson, Ella C., Schapira, Matthieu, Gstaiger, Matthias, Knapp, Stefan, Vedadi, Masoud, Min, Jinrong, Lajoie, Gilles A., Barsyte-Lovejoy, Dalia, Owen, Dafydd R., Schild-Poulter, Caroline, Arrowsmith, Cheryl H.
Published in Nature chemical biology (01.09.2024)
Published in Nature chemical biology (01.09.2024)
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Journal Article
Hydrophobically-modified chitosan foam: description and hemostatic efficacy
Dowling, Matthew B., PhD, Smith, William, BS, Balogh, Peter, BS, Duggan, Michael J., DVM, MacIntire, Ian C., BS, Harris, Erica, BS, Mesar, Tomaz, MD, Raghavan, Srinivasa R., PhD, King, David R., MD, LTC, USAR
Published in The Journal of surgical research (01.01.2015)
Published in The Journal of surgical research (01.01.2015)
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Journal Article
Expanding Hydrophobically Modified Chitosan Foam for Internal Surgical Hemostasis: Safety Evaluation in a Murine Model
Logun, Meghan T., Dowling, Matthew B., Raghavan, Srinivasa R., Wallace, Mandy L., Schmiedt, Chad, Stice, Steven, Karumbaiah, Lohitash
Published in The Journal of surgical research (01.07.2019)
Published in The Journal of surgical research (01.07.2019)
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