Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Huard, Kim, Smith, Aaron C, Cappon, Gregg, Dow, Robert L, Edmonds, David J, El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P, Griffith, David A, Kalgutkar, Amit S, Ross, Trenton T, Bagley, Scott W, Beebe, David, Bi, Yi-An, Cabral, Shawn, Crowley, Collin, Doran, Shawn D, Dowling, Matthew S, Liras, Spiros, Mascitti, Vincent, Niosi, Mark, Pfefferkorn, Jeffrey A, Polivkova, Jana, Préville, Cathy, Price, David A, Shavnya, Andre, Shirai, Norimitsu, Smith, Andrew H, Southers, James R, Tess, David A, Thuma, Benjamin A, Varma, Manthena V, Yang, Xiaojing
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Journal Article
A Synthesis of Echinopine B
Michels, Theo D., Dowling, Matthew S., Vanderwal, Christopher D.
Published in Angewandte Chemie International Edition (23.07.2012)
Published in Angewandte Chemie International Edition (23.07.2012)
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Journal Article
Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine
Dowling, Matthew B, Chaturvedi, Apurva, MacIntire, Ian C, Javvaji, Vishal, Gustin, John, Raghavan, Srinivasa R, Scalea, Thomas M, Narayan, Mayur
Published in Injury (01.10.2016)
Published in Injury (01.10.2016)
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Journal Article
Two Scalable Syntheses of (S)‑2-Methylazetidine
Dowling, Matthew S, Fernando, Dilinie P, Hou, Jie, Liu, Bo, Smith, Aaron C
Published in Journal of organic chemistry (01.04.2016)
Published in Journal of organic chemistry (01.04.2016)
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Journal Article
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Futatsugi, Kentaro, Kung, Daniel W, Orr, Suvi T. M, Cabral, Shawn, Hepworth, David, Aspnes, Gary, Bader, Scott, Bian, Jianwei, Boehm, Markus, Carpino, Philip A, Coffey, Steven B, Dowling, Matthew S, Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y, Li, Qifang, Clark, Ronald W, Erion, Derek M, Kou, Kou, Lee, Kyuha, Pabst, Brandon A, Perez, Sylvie M, Purkal, Julie, Jorgensen, Csilla C, Goosen, Theunis C, Gosset, James R, Niosi, Mark, Pettersen, John C, Pfefferkorn, Jeffrey A, Ahn, Kay, Goodwin, Bryan
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions
Dowling, Matthew, Samuelson, Jonathan, Fadl-Alla, Bahaa, Pondenis, Holly C, Byrum, Mark, Barger, Anne M, Fan, Timothy M
Published in PloS one (02.01.2019)
Published in PloS one (02.01.2019)
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Journal Article
Encapsulated fusion protein confers "sense and respond" activity to chitosan-alginate capsules to manipulate bacterial quorum sensing
Gupta, Apoorv, Terrell, Jessica L., Fernandes, Rohan, Dowling, Matthew B., Payne, Gregory F., Raghavan, Srinivasa R., Bentley, William E.
Published in Biotechnology and bioengineering (01.02.2013)
Published in Biotechnology and bioengineering (01.02.2013)
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Journal Article
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
Yazdi, Aliakbar Khalili, Perveen, Sumera, Dong, Cheng, Song, Xiaosheng, Dong, Aiping, Szewczyk, Magdalena M, Calabrese, Matthew F, Casimiro-Garcia, Agustin, Chakrapani, Subramanyam, Dowling, Matthew S, Ficici, Emel, Lee, Jisun, Montgomery, Justin I, O'Connell, Thomas N, Skrzypek, Grzegorz J, Tran, Tuan P, Troutman, Matthew D, Wang, Feng, Young, Jennifer A, Min, Jinrong, Barsyte-Lovejoy, Dalia, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Vedadi, Masoud, Owen, Dafydd R
Published in MedChemComm (20.03.2024)
Published in MedChemComm (20.03.2024)
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Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases
Ruggeri, Roger B, Buckbinder, Leonard, Bagley, Scott W, Carpino, Philip A, Conn, Edward L, Dowling, Matthew S, Fernando, Dilinie P, Jiao, Wenhua, Kung, Daniel W, Orr, Suvi T. M, Qi, Yingmei, Rocke, Benjamin N, Smith, Aaron, Warmus, Joseph S, Zhang, Yan, Bowles, Daniel, Widlicka, Daniel W, Eng, Heather, Ryder, Tim, Sharma, Raman, Wolford, Angela, Okerberg, Carlin, Walters, Karen, Maurer, Tristan S, Zhang, Yanwei, Bonin, Paul D, Spath, Samantha N, Xing, Gang, Hepworth, David, Ahn, Kay, Kalgutkar, Amit S
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Journal Article
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Huard, Kim, Ahn, Kay, Amor, Paul, Beebe, David A, Borzilleri, Kris A, Chrunyk, Boris A, Coffey, Steven B, Cong, Yang, Conn, Edward L, Culp, Jeffrey S, Dowling, Matthew S, Gorgoglione, Matthew F, Gutierrez, Jemy A, Knafels, John D, Lachapelle, Erik A, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Raymer, Brian, Ross, Trenton T, Shavnya, Andre, Smith, Aaron C, Subashi, Timothy A, Tesz, Gregory J, Thuma, Benjamin A, Tu, Meihua, Weaver, John D, Weng, Yan, Withka, Jane M, Xing, Gang, Magee, Thomas V
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Journal Article
Sprayable Foams Based on an Amphiphilic Biopolymer for Control of Hemorrhage Without Compression
Dowling, Matthew B, MacIntire, Ian C, White, Joseph C, Narayan, Mayur, Duggan, Michael J, King, David R, Raghavan, Srinivasa R
Published in ACS biomaterials science & engineering (08.06.2015)
Published in ACS biomaterials science & engineering (08.06.2015)
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Journal Article
Determination of efficacy of novel modified chitosan sponge dressing in a lethal arterial injury model in swine
De Castro, Gerard P, Dowling, Matthew B, Kilbourne, Michael, Keledjian, Kaspar, Driscoll, Ian R, Raghavan, Srinivasa R, Hess, John R, Scalea, Thomas M, Bochicchio, Grant V
Published in The journal of trauma and acute care surgery (01.04.2012)
Published in The journal of trauma and acute care surgery (01.04.2012)
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Journal Article
Route Selection and Optimization in the Synthesis of Two Imidazopyridine Inhibitors of DGAT‑2
Bader, Scott J, Herr, Michael, Aspnes, Gary E, Cabral, Shawn, Li, Qifang, Bian, Jianwei, Coffey, Steven B, Dowling, Matthew S, Fernando, Dilinie P, Jiao, Wenhua, Lavergne, Sophie Y, Kung, Daniel W
Published in Organic process research & development (16.03.2018)
Published in Organic process research & development (16.03.2018)
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Journal Article
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Edmonds, David J, Kung, Daniel W, Kalgutkar, Amit S, Filipski, Kevin J, Ebner, David C, Cabral, Shawn, Smith, Aaron C, Aspnes, Gary E, Bhattacharya, Samit K, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew F, Caspers, Nicole L, Cokorinos, Emily C, Conn, Edward L, Dowling, Matthew S, Eng, Heather, Feng, Bo, Fernando, Dilinie P, Genung, Nathan E, Herr, Michael, Kurumbail, Ravi G, Lavergne, Sophie Y, Lee, Esther C.-Y, Li, Qifang, Mathialagan, Sumathy, Miller, Russell A, Panteleev, Jane, Polivkova, Jana, Rajamohan, Francis, Reyes, Allan R, Salatto, Christopher T, Shavnya, Andre, Thuma, Benjamin A, Tu, Meihua, Ward, Jessica, Withka, Jane M, Xiao, Jun, Cameron, Kimberly O
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Journal Article
Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577
Smith, Aaron C, Kung, Daniel W, Shavnya, Andre, Brandt, Thomas A, Dent, Philip D, Genung, Nathan E, Cabral, Shawn, Panteleev, Jane, Herr, Michael, Yip, Ka Ning, Aspnes, Gary E, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Edmonds, Ian D, Fernando, Dilinie P, Herrinton, Paul M, Keene, Nandell F, Lavergne, Sophie Y, Li, Qifang, Polivkova, Jana, Rose, Colin R, Thuma, Benjamin A, Vetelino, Michael G, Wang, Guoqiang, Weaver, John D, Widlicka, Daniel W, Price Wiglesworth, Kristin E, Xiao, Jun, Zahn, Todd, Zhang, Yingxin
Published in Organic process research & development (15.06.2018)
Published in Organic process research & development (15.06.2018)
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Journal Article
Vesicle capture on patterned surfaces coated with amphiphilic biopolymers
Dowling, Matthew B, Javvaji, Vishal, Payne, Gregory F, Raghavan, Srinivasa R
Published in Soft matter (01.01.2011)
Published in Soft matter (01.01.2011)
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