Medicinal chemistry design principles for liver targeting through OATP transporters
Tu, Meihua, Mathiowetz, Alan M, Pfefferkorn, Jeffrey A, Cameron, Kimberly O, Dow, Robert L, Litchfield, John, Di, Li, Feng, Bo, Liras, Spiros
Published in Current topics in medicinal chemistry (01.04.2013)
Published in Current topics in medicinal chemistry (01.04.2013)
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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors
Huard, Kim, Bagley, Scott W, Menhaji-Klotz, Elnaz, Préville, Cathy, Southers, James A, Smith, Aaron C, Edmonds, David J, Lucas, John C, Dunn, Matthew F, Allanson, Nigel M, Blaney, Emma L, Garcia-Irizarry, Carmen N, Kohrt, Jeffrey T, Griffith, David A, Dow, Robert L
Published in Journal of organic chemistry (16.11.2012)
Published in Journal of organic chemistry (16.11.2012)
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Journal Article
High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid
Chirapu, Srinivas Reddy, Rotter, Charles J, Miller, Emily L, Varma, Manthena V, Dow, Robert L, Finn, M G
Published in Current topics in medicinal chemistry (01.04.2013)
Published in Current topics in medicinal chemistry (01.04.2013)
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Journal Article
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease
Gopalsamy, Ariamala, Aulabaugh, Ann E., Barakat, Amey, Beaumont, Kevin C., Cabral, Shawn, Canterbury, Daniel P., Casimiro-Garcia, Agustin, Chang, Jeanne S., Chen, Ming Z., Choi, Chulho, Dow, Robert L., Fadeyi, Olugbeminiyi O., Feng, Xidong, France, Scott P., Howard, Roger M., Janz, Jay M., Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H., King-Ahmad, Amanda, Knee, Kelly M., Kohrt, Jeffrey T., Limberakis, Chris, Liras, Spiros, Martinez, Carlos A., McClure, Kim F., Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J., O'Connell, Thomas N., Parikh, Mihir D., Piotrowski, David W., Plotnikova, Olga, Robinson, Ralph P., Sahasrabudhe, Parag, Sharma, Raman, Thuma, Benjamin A., Vasa, Dipy, Wei, Liuqing, Wenzel, A. Zane, Withka, Jane M., Xiao, Jun, Yayla, Hatice G.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Huard, Kim, Smith, Aaron C, Cappon, Gregg, Dow, Robert L, Edmonds, David J, El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P, Griffith, David A, Kalgutkar, Amit S, Ross, Trenton T, Bagley, Scott W, Beebe, David, Bi, Yi-An, Cabral, Shawn, Crowley, Collin, Doran, Shawn D, Dowling, Matthew S, Liras, Spiros, Mascitti, Vincent, Niosi, Mark, Pfefferkorn, Jeffrey A, Polivkova, Jana, Préville, Cathy, Price, David A, Shavnya, Andre, Shirai, Norimitsu, Smith, Andrew H, Southers, James R, Tess, David A, Thuma, Benjamin A, Varma, Manthena V, Yang, Xiaojing
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Journal Article
2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety
Dow, Robert L, Ammirati, Mark, Bagley, Scott W, Bhattacharya, Samit K, Buckbinder, Leonard, Cortes, Christian, El-Kattan, Ayman F, Ford, Kristen, Freeman, Gary B, Guimarães, Cristiano R. W, Liu, Shenping, Niosi, Mark, Skoura, Athanasia, Tess, David
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
Griffith, David A, Dow, Robert L, Huard, Kim, Edmonds, David J, Bagley, Scott W, Polivkova, Jana, Zeng, Dongxiang, Garcia-Irizarry, Carmen N, Southers, James A, Esler, William, Amor, Paul, Loomis, Kathrine, McPherson, Kirk, Bahnck, Kevin B, Préville, Cathy, Banks, Tereece, Moore, Dianna E, Mathiowetz, Alan M, Menhaji-Klotz, Elnaz, Smith, Aaron C, Doran, Shawn D, Beebe, David A, Dunn, Matthew F
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist
Griffith, David A, Hadcock, John R, Black, Shawn C, Iredale, Philip A, Carpino, Philip A, DaSilva-Jardine, Paul, Day, Robert, DiBrino, Joseph, Dow, Robert L, Landis, Margaret S, O’Connor, Rebecca E, Scott, Dennis O
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino-piperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist
GRIFFITH, David A, HADCOCK, John R, O'CONNOR, Rebecca E, SCOTT, Dennis O, BLACK, Shawn C, IREDALE, Philip A, CARPINO, Philip A, DASILVA-JARDINE, Paul, DAY, Robert, DIBRINO, Joseph, DOW, Robert L, LANDIS, Margaret S
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1
Schwaid, Adam G, Su, Chunyan, Loos, Paula, Wu, Jiang, Nguyen, Chuong, Stone, Kathryn L, Kanyo, Jean, Geoghegan, Kieran F, Bhattacharya, Samit K, Dow, Robert L, Buckbinder, Leonard, Carpino, Philip A
Published in ACS chemical biology (18.12.2015)
Published in ACS chemical biology (18.12.2015)
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Journal Article
Thyroid receptor agonists for the treatment of androgenetic alopecia
Li, Jie Jack, Mitchell, Lorna H., Dow, Robert L.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
Dow, Robert L, Li, Jian-Cheng, Pence, Michael P, Gibbs, E. Michael, LaPerle, Jennifer L, Litchfield, John, Piotrowski, David W, Munchhof, Michael J, Manion, Tara B, Zavadoski, William J, Walker, Gregory S, McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Published in ACS medicinal chemistry letters (12.05.2011)
Published in ACS medicinal chemistry letters (12.05.2011)
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Journal Article
Total synthesis of the polyether antibiotic ionomycin
Evans, David A, Dow, Robert L, Shih, Thomas L, Takacs, James M, Zahler, Robert
Published in Journal of the American Chemical Society (01.06.1990)
Published in Journal of the American Chemical Society (01.06.1990)
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Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor
Dow, Robert L., Andrews, Melissa P., Li, Jian-Cheng, Michael Gibbs, E., Guzman-Perez, Angel, LaPerle, Jennifer L., Li, Qifang, Mather, Dawn, Munchhof, Michael J., Niosi, Mark, Patel, Leena, Perreault, Christian, Tapley, Susan, Zavadoski, William J.
Published in Bioorganic & medicinal chemistry (01.09.2013)
Published in Bioorganic & medicinal chemistry (01.09.2013)
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Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif
Filipski, Kevin J., Guzman-Perez, Angel, Bian, Jianwei, Perreault, Christian, Aspnes, Gary E., Didiuk, Mary T., Dow, Robert L., Hank, Richard F., Jones, Christopher S., Maguire, Robert J., Tu, Meihua, Zeng, Dongxiang, Liu, Shenping, Knafels, John D., Litchfield, John, Atkinson, Karen, Derksen, David R., Bourbonais, Francis, Gajiwala, Ketan S., Hickey, Michael, Johnson, Theodore O., Humphries, Paul S., Pfefferkorn, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Journal Article
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment
Ammirati, Mark, Bagley, Scott W, Bhattacharya, Samit K, Buckbinder, Leonard, Carlo, Anthony A, Conrad, Rebecca, Cortes, Christian, Dow, Robert L, Dowling, Matthew S, El-Kattan, Ayman, Ford, Kristen, Guimarães, Cristiano R. W, Hepworth, David, Jiao, Wenhua, LaPerle, Jennifer, Liu, Shenping, Londregan, Allyn, Loria, Paula M, Mathiowetz, Alan M, Munchhof, Michael, Orr, Suvi T. M, Petersen, Donna N, Price, David A, Skoura, Athanasia, Smith, Aaron C, Wang, Jian
Published in ACS medicinal chemistry letters (12.11.2015)
Published in ACS medicinal chemistry letters (12.11.2015)
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Journal Article
Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity
Dow, Robert L, Carpino, Philip A, Hadcock, John R, Black, Shawn C, Iredale, Philip A, DaSilva-Jardine, Paul, Schneider, Steven R, Paight, Ernest S, Griffith, David A, Scott, Dennis O, O’Connor, Rebecca E, Nduaka, Chudy I
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents
Dow, Robert L, Carpino, Philip A, Gautreau, Denise, Hadcock, John R, Iredale, Philip A, Kelly-Sullivan, Dawn, Lizano, Jeffrey S, O’Connor, Rebecca E, Schneider, Steven R, Scott, Dennis O, Ward, Karen M
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
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Journal Article
Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core
Dow, Robert L., Andrews, Melissa, Aspnes, Gary E., Balan, Gayatri, Michael Gibbs, E., Guzman-Perez, Angel, Karki, Kapil, LaPerle, Jennifer L., Li, Jian-Cheng, Litchfield, John, Munchhof, Michael J., Perreault, Christian, Patel, Leena
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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Journal Article
Undesired versus designed enzymatic cleavage of linkers for liver targeting
Chirapu, Srinivas R., Bauman, Jonathan N., Eng, Heather, Goosen, Theunis C., Strelevitz, Timothy J., Sinha, Subhash C., Dow, Robert L., Finn, M. G.
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
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