In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity
Hadcock, John R., Griffith, David A., Iredale, Phillip A., Carpino, Phillip A., Dow, Robert L., Black, Shawn C., O’Connor, Rebecca, Gautreau, Denise, Lizano, Jeffrey S., Ward, Karen, Hargrove, Diane M., Kelly-Sullivan, Dawn, Scott, Dennis O.
Published in Biochemical and biophysical research communications (02.04.2010)
Published in Biochemical and biophysical research communications (02.04.2010)
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Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors
Bahnck, Kevin B., Shavnya, Andrei, Tao, Yong, Lilley, Susan C., Andrews, Melissa P., Aspnes, Gary E., Bernhardson, David J., Bill, David R., Bundesmann, Mark W., Dow, Robert L., Karki, Kapil, Le, Tung, Li, Qifang, Munchhof, Michael J., Nematalla, Asaad, Nihlawi, Mohammed, Patel, Leena, Perreault, Christian, Waldo, Michael
Published in Synthesis (Stuttgart) (18.10.2012)
Published in Synthesis (Stuttgart) (18.10.2012)
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Journal Article
Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles
Dow, Robert L., Hadcock, John R., Scott, Dennis O., Schneider, Steven R., Paight, Ernest S., Iredale, Philip A., Carpino, Philip A., Griffith, David A., Hammond, Marlys, DaSilva-Jardine, Paul
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Journal Article
New bicyclic cannabinoid receptor-1 (CB 1-R) antagonists
Carpino, Philip A., Griffith, David A., Sakya, Subas, Dow, Robert L., Black, Shawn C., Hadcock, John R., Iredale, Philip A., Scott, Dennis O., Fichtner, Michael W., Rose, Colin R., Day, Robert, Dibrino, Joseph, Butler, Mary, DeBartolo, Demetria B., Dutcher, Darrin, Gautreau, Denise, Lizano, Jeff S., O’Connor, Rebecca E., Sands, Michelle A., Kelly-Sullivan, Dawn, Ward, Karen M.
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
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Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics
Dow, Robert L., Schneider, Steven R., Paight, Ernest S., Hank, Richard F., Chiang, Phoebe, Cornelius, Peter, Lee, Eunsun, Newsome, William P., Swick, Andrew G., Spitzer, Josephine, Hargrove, Diane M., Patterson, Terrell A., Pandit, Jayvardhan, Chrunyk, Boris A., LeMotte, Peter K., Danley, Dennis E., Rosner, Michele H., Ammirati, Mark J., Simons, Samuel P., Schulte, Gayle K., Tate, Bonnie F., DaSilva-Jardine, Paul
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Potent and selective, sulfamide-based human β3-adrenergic receptor agonists
DOW, Robert L, PAIGHT, Ernest S, SCHNEIDER, Steven R, HADCOCK, John R, HARGROVE, Diane M, MARTIN, Kelly A, MAURER, Tristan S, NARDONE, Nancy A, TESS, David A, DASILVA-JARDINE, Paul
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist
Hadcock, John R, Carpino, Philip A, Iredale, Philip A, Dow, Robert L, Gautreau, Denise, Thiede, Lucinda, Kelly-Sullivan, Dawn, Lizano, Jeffrey S, Liu, Xingrong, Van Deusen, Jeffrey, Ward, Karen M, O'Connor, Rebecca E, Black, Shawn C, Griffith, David A, Scott, Dennis O
Published in BMC pharmacology (16.08.2010)
Published in BMC pharmacology (16.08.2010)
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Journal Article
Prevention of Proteinuria by a Novel, Subnanomolar ApoL1 Inhibitor: FR-OR105
Antonio, Brett M., Zahler, Nathan, Mechin, Ingrid, Theile, Jonathan W., Dow, Robert L., Volkmann, Robert A., Zellmer, Shannon G., Chdid, Lhoucine, Nair, Anil, Krafte, Douglas
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Journal Article
N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITOR
DOW ROBERT L, GRIFFITH DAVID ANDREW, AARON CHRISTOPHER SMITH, SCOTT WILLIAM BAGLEY
Year of Publication 26.03.2015
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Year of Publication 26.03.2015
Patent
Benzyloxazolidine-2,4-diones as potent hypoglycemic agents
Dow, Robert L, Bechle, Bruce M, Chou, Thomas T, Clark, David A, Hulin, Bernard, Stevenson, Ralph W
Published in Journal of medicinal chemistry (01.05.1991)
Published in Journal of medicinal chemistry (01.05.1991)
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Journal Article
Recent advances in drug transporter sciences: highlights from the year 2020
Chothe, Paresh P., Nakakariya, Masanori, Rotter, Charles J., Sandoval, Philip, Tohyama, Kimio
Published in Drug metabolism reviews (03.07.2021)
Published in Drug metabolism reviews (03.07.2021)
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Journal Article
Undesired vs. Designed Enzymatic Cleavage of Linkers for Liver Targeting
Chirapu, Srinivas R., Bauman, Jonathan N., Eng, Heather, Goosen, Theunis C., Strelevitz, Timothy J., Sinha, Subhash C., Dow, Robert L., Finn, M.G.
Published in Bioorganic & medicinal chemistry letters (08.01.2014)
Published in Bioorganic & medicinal chemistry letters (08.01.2014)
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Journal Article
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
Hanke, J H, Gardner, J P, Dow, R L, Changelian, P S, Brissette, W H, Weringer, E J, Pollok, B A, Connelly, P A
Published in The Journal of biological chemistry (12.01.1996)
Published in The Journal of biological chemistry (12.01.1996)
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Journal Article
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
Hanke, Jeffrey H., Gardner, Joseph P., Dow, Robert L., Changelian, Paul S., Brissette, William H., Weringer, Elora J., Pollok, Brian A., Connelly, Patricia A.
Published in The Journal of biological chemistry (12.01.1996)
Published in The Journal of biological chemistry (12.01.1996)
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Corrigendum to “Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor” [Bioorg. Med. Chem. 21 (2013) 5081–5097]
Dow, Robert L., Andrews, Melissa P., Li, Jian-Cheng, Michael Gibbs, E., Guzman-Perez, Angel, LaPerle, Jennifer L., Li, Qifang, Mather, Dawn, Munchhof, Michael J., Niosi, Mark, Patel, Leena, Perreault, Christian, Tapley, Susan, Zavadoski, William J.
Published in Bioorganic & medicinal chemistry (01.11.2013)
Published in Bioorganic & medicinal chemistry (01.11.2013)
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