Synthesis and Biological Evaluation of Aryl-phospho-indole as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
Alexandre, François-René, Amador, Agnès, Bot, Stéphanie, Caillet, Catherine, Convard, Thierry, Jakubik, Jocelyn, Musiu, Chiara, Poddesu, Barbara, Vargiu, Luana, Liuzzi, Michel, Roland, Arlène, Seifer, Maria, Standring, David, Storer, Richard, Dousson, Cyril B
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Is there any need for new, long-acting nucleos(t)ide analogues for the treatment of hepatitis B infection?
Durantel, David, Dousson, Cyril B., Lampertico, Pietro
Published in Journal of hepatology (01.05.2021)
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Published in Antiviral research (01.07.2020)
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Synthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4′-Ethynyl-2-fluoro-2′-deoxyadenosine)
Alexandre, François-René, Rahali, Rachid, Rahali, Houcine, Guillon, Sandra, Convard, Thierry, Fillgrove, Kerry, Lai, Ming-Tain, Meillon, Jean-Christophe, Xu, Min, Small, James, Dousson, Cyril B, Raheem, Izzat T
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors
Alexandre, François-René, Badaroux, Eric, Bilello, John P., Bot, Stéphanie, Bouisset, Tony, Brandt, Guillaume, Cappelle, Sylvie, Chapron, Christopher, Chaves, Dominique, Convard, Thierry, Counor, Clément, Da Costa, Daniel, Dukhan, David, Gay, Marion, Gosselin, Gilles, Griffon, Jean-François, Gupta, Kusum, Hernandez-Santiago, Brenda, La Colla, Massimiliano, Lioure, Marie-Pierre, Milhau, Julien, Paparin, Jean-Laurent, Peyronnet, Jérôme, Parsy, Christophe, Pierra Rouvière, Claire, Rahali, Houcine, Rahali, Rachid, Salanson, Aurélien, Seifer, Maria, Serra, Ilaria, Standring, David, Surleraux, Dominique, Dousson, Cyril B.
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
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A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A
Ironmonger, Alan, Shipton, Mark, Slater, Fiona, Szeto, Pete, Unthank, Matthew G., Alexandre, François-René, Caillet, Catherine, Dousson, Cyril B.
Published in Tetrahedron letters (30.05.2018)
Published in Tetrahedron letters (30.05.2018)
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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor
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Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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Development and Scale-Up of a Manufacturing Route for the Non-nucleoside Reverse Transcriptase Inhibitor GSK2248761A (IDX-899): Synthesis of an Advanced Key Chiral Intermediate
Bellingham, Richard, Borrett, Gary, Bret, Guillaume, Choudary, Bernadette, Colclough, David, Hayes, Jerome, Hayler, John, Hodnett, Neil, Ironmonger, Alan, Ochen, Augustine, Pascoe, David, Richardson, John, Vit, Erica, Alexandre, François-René, Caillet, Catherine, Amador, Agnès, Bot, Stéphanie, Bonaric, Séverine, da Costa, Daniel, Lioure, Marie-Pierre, Roland, Arlène, Rosinovsky, Elodie, Parsy, Christophe, Dousson, Cyril B
Published in Organic process research & development (16.02.2018)
Published in Organic process research & development (16.02.2018)
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Asymmetric hydrogenation reactions mediated by a new class of bicyclic bisphosphinites
Derrien, Nadine, Dousson, Cyril B., Roberts, Stanley M., Berens, Ulrich, Burk, Mark J., Ohff, Manuela
Published in Tetrahedron: asymmetry (27.08.1999)
Published in Tetrahedron: asymmetry (27.08.1999)
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2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION
GOSSELIN GILLES, MOUSSA ADEL M, GRIFFON JEAN FRANCOIS, RAHALI HOUCINE, ALEXANDRE FRANCOIS RENE, DOUSSON CYRIL B, STEWART ALISTAIR JAMES, DUKHAN DAVID, MAYES BENJAMIN ALEXANDER, PIERRA CLAIRE, PARSY CHRISTOPHE CLAUDE, SURLERAUX DOMINIQUE
Year of Publication 22.07.2015
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Year of Publication 22.07.2015
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Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase
Mortlock, Andrew A, Foote, Kevin M, Heron, Nicola M, Jung, Frédéric H, Pasquet, Georges, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, De Savi, Chris, Roberts, Nicola J, Johnson, Trevor, Dousson, Cyril B, Hill, George B, Perkins, David, Hatter, Glenn, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Crafter, Claire, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen, Khatri, Liz, Brady, Madeleine C, Kearney, Sarah, McKillop, David, Rhead, Steve, Parry, Tony, Green, Stephen
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS
RAHALI HOUCINE, CONVARD THIERRY, DEROCK MICHEL, DOUSSON CYRIL B, ALEXANDRE FRANCOIS RENE, PAPARIN JEAN LAURENT, DUKHAN DAVID, DA COSTA DANIEL, PIERRA CLAIRE, PARSY CHRISTOPHE CLAUDE, BRANDT GUILLAUME, SURLERAUX DOMINIQUE
Year of Publication 25.10.2012
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Year of Publication 25.10.2012
Patent