FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models
O'Farrell, Marie, Duke, Greg, Crowley, Richard, Buckley, Douglas, Martins, Eduardo B, Bhattacharya, Dipankar, Friedman, Scott L, Kemble, George
Published in Scientific reports (19.09.2022)
Published in Scientific reports (19.09.2022)
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Journal Article
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression
Ventura, Richard, Mordec, Kasia, Waszczuk, Joanna, Wang, Zhaoti, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George, Heuer, Timothy S.
Published in EBioMedicine (01.08.2015)
Published in EBioMedicine (01.08.2015)
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Journal Article
FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George
Published in EBioMedicine (01.02.2017)
Published in EBioMedicine (01.02.2017)
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Journal Article
Structures of Active and Latent PAI-1: A Possible Stabilizing Role for Chloride Ions
Stout, Thomas J, Graham, Hugh, Buckley, Douglas I, Matthews, David J
Published in Biochemistry (Easton) (25.07.2000)
Published in Biochemistry (Easton) (25.07.2000)
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Journal Article
Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target
Buckley, Douglas, Duke, Gregory, Heuer, Timothy S, O'Farrell, Marie, Wagman, Allan S, McCulloch, William, Kemble, George
Published in Pharmacology & therapeutics (Oxford) (01.09.2017)
Published in Pharmacology & therapeutics (Oxford) (01.09.2017)
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Journal Article
Abstract 4743: Preclinical studies characterize tumor type sensitivity to FASN inhibition and the mechanism and efficacy of novel drug combinations with TVB-2640
Heuer, Timothy S., Ventura, Richard, Lai, Julie, Waszczuk, Joanna, Rubio, Claudia, Hammonds, Glenn, O’ Farrell, Marie, Buckley, Douglas, Kemble, George
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract C175: FASN inhibition studies in preclinical tumor models identify biomarkers that align with in vitro and in vivo sensitivity to TVB-2640
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Waszczuk, Joanna, Rubio, Claudia, O' Farrell, Marie, Buckley, Douglas, Kemble, George
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Abstract 4446: Discovery of tumor types highly susceptible to FASN inhibition and biomarker candidates for clinical analysis
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Waszczuk, Joanna, Hammonds, Glenn, Fridlib, Marina, Johnson, Russell, Hu, Lily, Wagman, Allan, O'Farrell, Marie, Buckley, Douglas, Kemble, George
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 1815: Efficacy of FASN-selective small molecule inhibitors in preclinical tumor models
Heuer, Timothy S., Ventura, Richard, Waszczuk, Joanna, Mordec, Kasia, Lai, Julie, Johnson, Russell, Hu, Lilly, Cai, Haiying, Wagman, Allan, Buckley, Douglas, Parish, Stanley T., Bruckheimer, Elizabeth, Kemble, George
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract B261: Characterization of FASN-selective small-molecule inhibitors in preclinical tumor models
Heuer, Timothy S., Chen, Minchao, Ventura, Richard, Waszczuk, Joanna, Yendluri, Satya, Lai, Julie, Tep, Samnang, Feng, Shirley, Johnson, Russell, Zaharia, Cristiana, Buckley, Douglas, Kemble, George
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Heterocyclic modulators of lipid synthesis
Buckley, Douglas I, Wagman, Allan S, Evanchik, Marc, McDowell, Robert S, Duke, Gregory
Year of Publication 07.03.2024
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Year of Publication 07.03.2024
Patent
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
Buckley, Douglas I, Wagman, Allan S, Mcdowell, Robert S, Evanchik, Marc, Duke, Gregory
Year of Publication 21.12.2023
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Year of Publication 21.12.2023
Patent
Heterocyclic modulators of lipid synthesis
Buckley, Douglas I, Wagman, Allan S, Evanchik, Marc, McDowell, Robert S, Duke, Gregory
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent
Heterocyclic modulators of lipid synthesis
Buckley, Douglas, Wagman, Allan S, Evanchik, Marc, McDowell, Robert S, Duke, Gregory
Year of Publication 11.04.2023
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Year of Publication 11.04.2023
Patent
Heterocyclic modulators of lipid synthesis
Buckley, Douglas I, Wagman, Allan S, Mcdowell, Robert S, Evanchik, Marc, Duke, Gregory
Year of Publication 25.11.2022
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Year of Publication 25.11.2022
Patent
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
MCDOWELL, Robert S, DUKE, Gregory, BUCKLEY, Douglas, WAGMAN, Allan S, EVANCHIK, Marc
Year of Publication 27.10.2022
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Year of Publication 27.10.2022
Patent
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
MCDOWELL, Robert S, DUKE, Gregory, BUCKLEY, Douglas, WAGMAN, Allan S, EVANCHIK, Marc
Year of Publication 22.09.2022
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Year of Publication 22.09.2022
Patent