Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.
Published in Scientific reports (12.06.2018)
Published in Scientific reports (12.06.2018)
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Journal Article
Preclinical evaluation of EC145, a folate-Vinca alkaloid conjugate
REDDY, Joseph A, DORTON, Ryan, WESTRICK, Elaine, DAWSON, Alicia, SMITH, Terri, XU, Le-Cun, VETZEL, Marilynn, KLEINDL, Paul, VLAHOV, Iontcho R, LEAMON, Christopher P
Published in Cancer research (Chicago, Ill.) (01.05.2007)
Published in Cancer research (Chicago, Ill.) (01.05.2007)
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Journal Article
Impact of High and Low Folate Diets on Tissue Folate Receptor Levels and Antitumor Responses Toward Folate-Drug Conjugates
Leamon, Christopher P, Reddy, Joseph A, Dorton, Ryan, Bloomfield, Alicia, Emsweller, Kristen, Parker, Nikki, Westrick, Elaine
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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Journal Article
High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide
Guertin, Amy D, O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A, Cristescu, Razvan, Haines, Brian B, Hinton, Marlene C, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L, Schmidt, Emmett V, Dussault, Isabelle, Leamon, Christopher P
Published in Molecular cancer therapeutics (01.08.2016)
Published in Molecular cancer therapeutics (01.08.2016)
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Journal Article
Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate
Leamon, Christopher P, Reddy, Joseph A, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Vetzel, Marilynn, Kleindl, Paul, Hahn, Spencer, Wang, Kevin, Vlahov, Iontcho R
Published in Bioconjugate chemistry (19.06.2019)
Published in Bioconjugate chemistry (19.06.2019)
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Journal Article
Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship
Leamon, Christopher P, Vlahov, Iontcho R, Reddy, Joseph A, Vetzel, Marilynn, Santhapuram, Hari Krishna R, You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy F, Westrick, Elaine
Published in Bioconjugate chemistry (19.03.2014)
Published in Bioconjugate chemistry (19.03.2014)
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Journal Article
Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue
Leamon, Christopher P, Reddy, Joseph A, Vetzel, Marilynn, Dorton, Ryan, Westrick, Elaine, Parker, Nikki, Wang, Yu, Vlahov, Iontcho
Published in Cancer research (Chicago, Ill.) (01.12.2008)
Published in Cancer research (Chicago, Ill.) (01.12.2008)
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Journal Article
Abstract 3035: Development and characterization of CCK2R-targeted SMDCs and identification of GIST as a potential therapeutic indication
Shillingford, Jonathan M., Reddy, Joseph A., Nelson, Melissa, Vetzel, Marilynn, Parham, Garth L., Dorton, Ryan, Guan, John, Parker, Nikki, Chu, Haiyan, Vlahov, Iontcho A., Leamon, Christopher P.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy
Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Dorton, Ryan, Bloomfield, Alicia, Vetzel, Marilynn, Klein, Patrick J., Westrick, Elaine, Xu, Le-cun, Wang, Yu
Published in Cancer chemotherapy and pharmacology (01.06.2017)
Published in Cancer chemotherapy and pharmacology (01.06.2017)
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Journal Article
Preclinical Antitumor Activity of a Novel Folate-Targeted Dual Drug Conjugate
Leamon, Christopher P, Reddy, Joseph A, Vlahov, Iontcho R, Westrick, Elaine, Dawson, Alicia, Dorton, Ryan, Vetzel, Marilynn, Santhapuram, Hari Krishna, Wang, Yu
Published in Molecular pharmaceutics (01.09.2007)
Published in Molecular pharmaceutics (01.09.2007)
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Journal Article
Abstract 4462: Structure-activity relationship studies for PSMA-targeted tubulysin conjugates
Wang, Kevin, Hahn, Spencer, Santhapuram, Hari, Qi, Longwu, Kleindl, Paul, Vaughn, Jeremy, You, Fei, Reddy, Joe, Dorton, Ryan, Leamon, Christopher, Vlahov, Iontcho
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications
Leamon, Christopher P, Reddy, Joseph A, Klein, Patrick J, Vlahov, Iontcho R, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Westrick, Elaine, Parker, Nikki, Bruna, Kristen, Vetzel, Marilynn, Gehrke, Mark, Nicoson, Jeffrey S, Messmann, Richard A, LoRusso, Patricia M, Sausville, Edward A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Journal Article
Abstract 2145: PSMA-specific anti-tumor activity of the targeted-tubulysin conjugate, EC1169
Reddy, Joseph A., Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Vetzel, Marilynn, Hahn, Spencer, Vlahov, Iontcho, Leamon, Christopher
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Abstract 1929: Antifolates as folate receptor targeting ligands: Design and synthesis of their conjugates with cytotoxic agents
Vlahov, Iontcho, You, Fei, Dorton, Ryan, Westrick, Elaine, Reddy, Joseph, Leamon, Christopher P.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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