Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Park, Jang-June, Thi, Emily P, Carpio, Victor H, Bi, Yingzhi, Cole, Andrew G, Dorsey, Bruce D, Fan, Kristi, Harasym, Troy, Iott, Christina L, Kadhim, Salam, Kim, Jin Hyang, Lee, Amy C H, Nguyen, Duyan, Paratala, Bhavna S, Qiu, Ruiqing, White, Andre, Lakshminarasimhan, Damodharan, Leo, Christopher, Suto, Robert K, Rijnbrand, Rene, Tang, Sunny, Sofia, Michael J, Moore, Chris B
Published in Nature communications (22.02.2021)
Published in Nature communications (22.02.2021)
Get full text
Journal Article
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)
Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
Get full text
Journal Article
Discovery of a Potent, Selective, and Orally Active Proteasome Inhibitor for the Treatment of Cancer
Dorsey, Bruce D, Iqbal, Mohamed, Chatterjee, Sankar, Menta, Ernesto, Bernardini, Raffaella, Bernareggi, Alberto, Cassarà, Paolo G, D’Arasmo, Germano, Ferretti, Edmondo, De Munari, Sergio, Oliva, Ambrogio, Pezzoni, Gabriella, Allievi, Cecilia, Strepponi, Ivan, Ruggeri, Bruce, Ator, Mark A, Williams, Michael, Mallamo, John P
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
Get full text
Journal Article
Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2
Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Benjamin J, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M
Published in The Journal of immunology (1950) (01.10.2011)
Published in The Journal of immunology (1950) (01.10.2011)
Get full text
Journal Article
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis
Stump, Kristine L, Lu, Lily D, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Ben J, Angeles, Thelma S, Albom, Mark S, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M
Published in Arthritis research & therapy (21.04.2011)
Published in Arthritis research & therapy (21.04.2011)
Get full text
Journal Article
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment
Mirza, Amar N, Fry, Micah A, Urman, Nicole M, Atwood, Scott X, Roffey, Jon, Ott, Gregory R, Chen, Bin, Lee, Alex, Brown, Alexander S, Aasi, Sumaira Z, Hollmig, Tyler, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce R, Zificsak, Craig A, Sirota, Marina, Tang, Jean Y, Butte, Atul, Epstein, Ervin, Sarin, Kavita Y, Oro, Anthony E
Published in JCI insight (02.11.2017)
Published in JCI insight (02.11.2017)
Get full text
Journal Article
Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase
Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew A, Cheng, Mangeng, Quail, Matthew, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Haltiwanger, R. Curtis, Wells-Knecht, Kevin, Ott, Gregory R, Ghose, Arup K, Ator, Mark A, Ruggeri, Bruce, Dorsey, Bruce D
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
Get full text
Journal Article
Discovery and Process Synthesis of Novel 2,7-Pyrrolo[2,1-f][1,2,4]triazines
Thieu, Tho, Sclafani, Joseph A, Levy, Daniel V, McLean, Andrew, Breslin, Henry J, Ott, Gregory R, Bakale, Roger P, Dorsey, Bruce D
Published in Organic letters (19.08.2011)
Published in Organic letters (19.08.2011)
Get full text
Journal Article
Synthesis and Pharmacological Evaluation of N-(3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a Potent Antimitotic Agent
Shetty, Rupa S, Lee, Younghee, Liu, Bin, Husain, Arifa, Joseph, Rhoda W, Lu, Yixin, Nelson, David, Mihelcic, John, Chao, Wenchun, Moffett, Kristofer K, Schumacher, Andreas, Flubacher, Dietmar, Stojanovic, Aleksandar, Bukhtiyarova, Marina, Williams, Ken, Lee, Kyoung-Jin, Ochman, Alexander R, Saporito, Michael S, Moore, William R, Flynn, Gary A, Dorsey, Bruce D, Springman, Eric B, Fujimoto, Ted, Kelly, Martha J
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
Get full text
Journal Article
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
Wan, Weihua, Albom, Mark S., Lu, Lihui, Quail, Matthew R., Becknell, Nadine C., Weinberg, Linda R., Reddy, Dandu R., Holskin, Beverly P., Angeles, Thelma S., Underiner, Ted L., Meyer, Sheryl L., Hudkins, Robert L., Dorsey, Bruce D., Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng
Published in Blood (15.02.2006)
Published in Blood (15.02.2006)
Get full text
Journal Article
Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors
Mesaros, Eugen F, Thieu, Tho V, Wells, Gregory J, Zificsak, Craig A, Wagner, Jason C, Breslin, Henry J, Tripathy, Rabindranath, Diebold, James L, McHugh, Robert J, Wohler, Ashley T, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Huang, Zeqi, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin J, Aimone, Lisa D, Cheng, Mangeng, Ator, Mark A, Ott, Gregory R, Dorsey, Bruce D
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
Get full text
Journal Article
Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1
Liu, Bin, Lee, Younghee, Zou, Jinming, Petrassi, H. Michael, Joseph, Rhoda W., Chao, Wenchun, Michelotti, Enrique L., Bukhtiyarova, Marina, Springman, Eric B., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Get full text
Journal Article
Structure–Activity Relationships and Discovery of (S)‑6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro‑6H‑pyrido[1,2‑h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer
Gotchev, Dimitar, Dorsey, Bruce D., Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C.-H., Cole, Andrew G., Sofia, Michael J.
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
Get full text
Journal Article
Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer
Gotchev, Dimitar, Dorsey, Bruce D, Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C-H, Cole, Andrew G, Sofia, Michael J
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
Get full text
Journal Article
Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836
Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Mesaros, Eugen F., Thi, Emily P., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lee, Amy C. H., Olland, Andrea, Suto, Robert K., Sofia, Michael J.
Published in Journal of medicinal chemistry (04.09.2024)
Published in Journal of medicinal chemistry (04.09.2024)
Get full text
Journal Article
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA
Liu, Fei, Lee, Amy C. H, Guo, Fang, Kondratowicz, Andrew S, Micolochick Steuer, Holly M, Miller, Angela, Bailey, Lauren D, Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G, Cuconati, Andrea, Cole, Andrew G, Gotchev, Dimitar, Dorsey, Bruce D, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Gao, Min
Published in Journal of virology (25.08.2021)
Published in Journal of virology (25.08.2021)
Get full text
Journal Article
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506
Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Quintero, Jorge G., Yi Fan, Kristi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Phelps, Janet R., Lee, Amy C.H., Thi, Emily P., Chiu, Tim, Tang, Sunny, Horanyi, Peter S., Mayclin, Stephen J., Harasym, Troy O., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
Get full text
Journal Article
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation
Mani, Nagraj, Cole, Andrew G, Phelps, Janet R, Ardzinski, Andrzej, Cobarrubias, Kyle D, Cuconati, Andrea, Dorsey, Bruce D, Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O, Kadhim, Salam, Kultgen, Steven G, Lee, Amy C H, Li, Alice H L, Long, Quanxin, Majeski, Sara A, Mao, Richeng, McClintock, Kevin D, Reid, Stephen P, Rijnbrand, Rene, Snead, Nicholas M, Micolochick Steuer, Holly M, Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J
Published in Antimicrobial agents and chemotherapy (01.06.2018)
Published in Antimicrobial agents and chemotherapy (01.06.2018)
Get full text
Journal Article
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein
Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Burns, Robbin, Chiu, Tim, Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Harasym, Troy O., Kadhim, Salam, Kowalski, Roseann, Kultgen, Steven G., Lee, Amy C.H., Li, Alice H., Majeski, Sara A., Miller, Angela, Pasetka, Chris, Reid, Stephen P., Rijnbrand, Rene, Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Teng, Xiaowei, Wang, Xiaohe, Sofia, Michael J.
Published in Antiviral research (01.01.2022)
Published in Antiviral research (01.01.2022)
Get full text
Journal Article
Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators
Mesaros, Eugen F., Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J., Ardzinski, Andrzej, Stever, Kim, Micolochick Steuer, Holly M., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lam, Angela M., Thi, Emily P., Dorsey, Bruce D., Sofia, Michael J.
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
Get full text
Journal Article