Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells
Bröer, Angelika, Gauthier-Coles, Gregory, Rahimi, Farid, van Geldermalsen, Michelle, Dorsch, Dieter, Wegener, Ansgar, Holst, Jeff, Bröer, Stefan
Published in The Journal of biological chemistry (15.03.2019)
Published in The Journal of biological chemistry (15.03.2019)
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EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
BLADT, Friedhelm, FADEN, Bettina, PEHL, Ulrich, STIEBER, Frank, SCHADT, Oliver, BLAUKAT, Andree, FRIESE-HAMIM, Manja, KNUEHL, Christine, WILM, Claudia, FITTSCHEN, Claus, GRÄDLER, Ulrich, MEYRING, Michael, DORSCH, Dieter, JAEHRLING, Frank
Published in Clinical cancer research (01.06.2013)
Published in Clinical cancer research (01.06.2013)
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Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa
MEDERSKI, Werner W. K. R, DORSCH, Dieter, ANZALI, Soheila, GLEITZ, Johannes, CEZANNE, Bertram, TSAKLAKIDIS, Christos
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
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Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects
Schindler, Christina E. M, Baumann, Hannah, Blum, Andreas, Böse, Dietrich, Buchstaller, Hans-Peter, Burgdorf, Lars, Cappel, Daniel, Chekler, Eugene, Czodrowski, Paul, Dorsch, Dieter, Eguida, Merveille K. I, Follows, Bruce, Fuchß, Thomas, Grädler, Ulrich, Gunera, Jakub, Johnson, Theresa, Jorand Lebrun, Catherine, Karra, Srinivasa, Klein, Markus, Knehans, Tim, Koetzner, Lisa, Krier, Mireille, Leiendecker, Matthias, Leuthner, Birgitta, Li, Liwei, Mochalkin, Igor, Musil, Djordje, Neagu, Constantin, Rippmann, Friedrich, Schiemann, Kai, Schulz, Robert, Steinbrecher, Thomas, Tanzer, Eva-Maria, Unzue Lopez, Andrea, Viacava Follis, Ariele, Wegener, Ansgar, Kuhn, Daniel
Published in Journal of chemical information and modeling (23.11.2020)
Published in Journal of chemical information and modeling (23.11.2020)
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Discovery and Optimization of 2‑Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity
Buchstaller, Hans-Peter, Anlauf, Uwe, Dorsch, Dieter, Kuhn, Daniel, Lehmann, Martin, Leuthner, Birgitta, Musil, Djordje, Radtki, Daniela, Ritzert, Claudio, Rohdich, Felix, Schneider, Richard, Esdar, Christina
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Abstract 1482: M4645 is a potent and highly selective inhibitor of disease relevant cKIT mutations for the treatment of metastatic or recurrent GIST
Linde, Nina, Blum, Andreas, Dorsch, Dieter, Graedler, Ulrich, Busch, Michael, Glaser, Nina, Petersson, Carl, Ruff, Aaron, Sherbetjian, Eva, Esdar, Christina
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Identification of M4205A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors
Blum, Andreas, Dorsch, Dieter, Linde, Nina, Brandstetter, Susanne, Buchstaller, Hans-Peter, Busch, Michael, Glaser, Nina, Grädler, Ulrich, Ruff, Aaron, Petersson, Carl, Schieferstein, Hanno, Sherbetjian, Eva, Esdar, Christina
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors
Dorsch, Dieter, Schadt, Oliver, Stieber, Frank, Meyring, Michael, Grädler, Ulrich, Bladt, Friedhelm, Friese-Hamim, Manja, Knühl, Christine, Pehl, Ulrich, Blaukat, Andree
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models
Buchstaller, Hans-Peter, Anlauf, Uwe, Dorsch, Dieter, Kögler, Sarah, Kuhn, Daniel, Lehmann, Martin, Leuthner, Birgitta, Lodholz, Sara, Musil, Djordje, Radtki, Daniela, Rettig, Corinna, Ritzert, Claudio, Rohdich, Felix, Schneider, Richard, Wegener, Ansgar, Weigt, Stefan, Wilkinson, Kai, Esdar, Christina
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Discovery of novel 7-azaindoles as PDK1 inhibitors
Wucherer-Plietker, Margarita, Merkul, Eugen, Müller, Thomas J.J., Esdar, Christina, Knöchel, Thorsten, Heinrich, Timo, Buchstaller, Hans-Peter, Greiner, Hartmut, Dorsch, Dieter, Finsinger, Dirk, Calderini, Michel, Bruge, David, Grädler, Ulrich
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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