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Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
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ubiquitin ligase COP1 is a critical negative regulator of p53
Dornan, D, Wertz, I, Shimizu, H, Arnott, D, Frantz, G.D, Dowd, P, O'Rourke, K, Koeppen, H, Dixit, V.M
Published in Nature (06.05.2004)
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Extracellular matrix specific protein fingerprints measured in serum can separate pancreatic cancer patients from healthy controls
Willumsen, Nicholas, Bager, Cecilie L, Leeming, Diana J, Smith, Victoria, Karsdal, Morten A, Dornan, David, Bay-Jensen, Anne-Christine
Published in BMC cancer (21.11.2013)
Published in BMC cancer (21.11.2013)
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ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
Dornan, David, Shimizu, Harumi, Mah, Angie, Dudhela, Tanay, Eby, Michael, O'Rourke, Karen, Seshagiri, Somasekar, Dixit, Vishva M
Published in Science (American Association for the Advancement of Science) (25.08.2006)
Published in Science (American Association for the Advancement of Science) (25.08.2006)
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Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase
Wertz, Ingrid E., O'Rourke, Karen M., Zhang, Zemin, Dornan, David, Arnott, David, Deshaies, Raymond J., Dixit, Vishva M.
Published in Science (American Association for the Advancement of Science) (27.02.2004)
Published in Science (American Association for the Advancement of Science) (27.02.2004)
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Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone
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Published in Haematologica (Roma) (01.06.2012)
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Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer
Willumsen, Nicholas, Bager, Cecilie L., Leeming, Diana J., Smith, Victoria, Christiansen, Claus, Karsdal, Morten A., Dornan, David, Bay‐Jensen, Anne‐Christine
Published in Cancer medicine (Malden, MA) (01.10.2014)
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Effect of FCGR2A and FCGR3A variants on CLL outcome
Dornan, David, Spleiss, Olivia, Yeh, Ru-Fang, Duchateau-Nguyen, Guillemette, Dufour, Annika, Zhi, Jianguo, Robak, Tadeusz, Moiseev, Sergey I., Dmoszynska, Anna, Solal-Celigny, Philippe, Warzocha, Krzysztof, Loscertales, Javier, Catalano, John, Afanasiev, Boris V., Larratt, Loree, Rossiev, Viktor A., Bence-Bruckler, Isabelle, Geisler, Christian H., Montillo, Marco, Wenger, Michael K., Weisser, Martin
Published in Blood (18.11.2010)
Published in Blood (18.11.2010)
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COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
DORNAN, David, BHEDDAH, Sheila, NEWTON, Kim, INCE, William, FRANTZ, Gretchen D, DOWD, Patrick, KOEPPEN, Hartmut, DIXIT, Vishva M, FRENCH, Dorothy M
Published in Cancer research (Chicago, Ill.) (15.10.2004)
Published in Cancer research (Chicago, Ill.) (15.10.2004)
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605 Systemically administered HER2-targeted ISACs provoke a rapid, local response that engages the innate and adaptive arms of the immune system to eradicate tumors in preclinical models
LeBlanc, Heidi, Pearson, Cecelia, Kenkel, Justin, Blum, LIsa, Ho, Po, Luo, Angela, Laura, Richard, Zhou, Matthew, Gregorio, Joshua, Luo, Andrew, Ackerman, Shelley, Safina, Brian, Dornan, David, Alonso, Michael, Kowanetz, Marcin
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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784 BDC-2034: discovery of a CEA-targeting immune-stimulating antibody conjugate (ISAC) for solid tumors
Mallet, William, Gadkari, Rishali, Pearson, Cecelia, Torrez Dulgeroff, Laughing Bear, Luo, Angela, Luo, AAngela Luondrew, Melrose, Jennifer, Nolin, Jess, Lee, Arthur, Zhou, Matthew, Anand, Puneet, Sarma, Ganapathy, Henning, Karla, Blum, Lisa, Chapin, Steven, Bogaert, Liz, Ackerman, Shelley, Kudirka, Romas, Shen, Yuyi, Husain, Amreen, Perez, Edith, Kowanetz, Marcin, Alonso, Michael, Safina, Brian, Dornan, David
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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603 Covalent attachment of a TLR7/8 agonist to tumor-targeting antibodies drives potent anti-tumor efficacy by synergistically activating FcgR- and TLR- signaling and enables safe systemic administration
Ackerman, Shelley, Hartmann, Felix, Pearson, Cecelia, Gonzalez, Joseph, Ho, Po Yi, Kimmey, Samuel, Luo, Andrew, Ackerman, Benjamin, Lee, Arthur, Laura, Richard, Paik, Jason, Henning, Karla, Jackson, David, Chapin, Steven, Devens, Bruce, Dornan, David, Bendall, Sean, Engleman, Edgar, Alonso, Michael
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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401 Phase 1/2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001 with or without immune checkpoint inhibitor in patients with advanced HER2-expressing solid tumors
Sharma, Manish, Dumbrava, Ecaterina Ileana, Carvajal, Richard, Catenacci, Daniel, Emens, Leisha, Hanna, Glenn, Juric, Dejan, Kang, Yoon-Koo, Lee, Jeeyun, Lee, Keun-Wook, Li, Bob, Moore, Kathleen, Pegram, Mark, Pohlmann, Paula, Rasco, Drew, Spira, Alexander, Tan, Antoinette, Wang, Ding, Ackerman, Shelley, LeBlanc, Heidi, Dornan, David, Kowanetz, Marcin, Alonso, Michael, Perez, Edith
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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DNA-dependent Acetylation of p53 by the Transcription Coactivator p300
Dornan, David, Shimizu, Harumi, Perkins, Neil D, Hupp, Ted R
Published in The Journal of biological chemistry (11.04.2003)
Published in The Journal of biological chemistry (11.04.2003)
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The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53
Dornan, David, Shimizu, Harumi, Burch, Lindsay, Smith, Amanda J., Hupp, Ted R.
Published in Molecular and Cellular Biology (01.12.2003)
Published in Molecular and Cellular Biology (01.12.2003)
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