10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d]pyridazine-1,9(2 H,6 H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants
Wiscount, Catherine M., Williams, Peter D., Tran, Lekhanh O., Embrey, Mark W., Fisher, Thorsten E., Sherman, Vanessa, Homnick, Carl F., Donnette Staas, D., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Wang, ZiQiang, Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Hazuda, Daria J., Day, Alysha M., Gabryelski, Lori J., Ecto, Linda T., Schleif, William A., DiStefano, Daniel J., Kochansky, Christopher J., Reza Anari, M.
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists
Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold
Williams, Peter D., Staas, Donnette D., Venkatraman, Shankar, Loughran, H. Marie, Ruzek, Rowena D., Booth, Theresa M., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Feuston, Bradley P., Ecto, Linda T., Flynn, Jessica A., DiStefano, Daniel J., Hazuda, Daria J., Bahnck, Carolyn M., Himmelberger, Amy L., Dornadula, Geetha, Hrin, Renee C., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Grobler, Jay A.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats
Bell, Ian M., Stump, Craig A., Gallicchio, Steven N., Staas, Donnette D., Zartman, C. Blair, Moore, Eric L., Sain, Nova, Urban, Mark, Bruno, Joseph G., Calamari, Amy, Kemmerer, Amanda L., Mosser, Scott D., Fandozzi, Christine, White, Rebecca B., Zrada, Matthew M., Selnick, Harold G., Graham, Samuel L., Vacca, Joseph P., Kane, Stefanie A., Salvatore, Christopher A.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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[11C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor
Bell, Ian M, Gallicchio, Steven N, Stump, Craig A, Bruno, Joseph G, Fan, Hong, Gantert, Liza T, Hostetler, Eric D, Kemmerer, Amanda L, McWherter, Melody, Moore, Eric L, Mosser, Scott D, Purcell, Mona L, Riffel, Kerry, Salvatore, Christopher A, Sanabria-Bohórquez, Sandra, Staas, Donnette D, White, Rebecca B, Williams, Mangay, Zartman, C. Blair, Cook, Jacquelynn J, Hargreaves, Richard J, Kane, Stefanie A, Graham, Samuel L, Selnick, Harold G
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
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8-Hydroxy-3,4-dihydropyrrolo[1,2- a]pyrazine-1(2 H)-one HIV-1 integrase inhibitors
Fisher, Thorsten E., Kim, Boyoung, Staas, Donnette D., Lyle, Terry A., Young, Steven D., Vacca, Joseph P., Zrada, Matthew M., Hazuda, Daria J., Felock, Peter J., Schleif, William A., Gabryelski, Lori J., Anari, M. Reza, Kochansky, Christopher J., Wai, John S.
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors
Wai, John S., Kim, Boyoung, Fisher, Thorsten E., Zhuang, Linghang, Embrey, Mark W., Williams, Peter D., Staas, Donnette D., Culberson, Chris, Lyle, Terry A., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Schleif, William A., Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Ellis, Joan D., Mallai, Rama, Young, Steven D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability
Staas, Donnette D., Savage, Kelly L., Sherman, Vanessa L., Shimp, Heidi L., Lyle, Terry A., Tran, Lekhanh O., Wiscount, Catherine M., McMasters, Daniel R., Sanderson, Philip E.J., Williams, Peter D., Lucas, Bobby J., Krueger, Julie A., Dale Lewis, S., White, Rebecca B., Yu, Sean, Wong, Bradley K., Kochansky, Christopher J., Reza Anari, M., Yan, Youwei, Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry (15.10.2006)
Published in Bioorganic & medicinal chemistry (15.10.2006)
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PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS
Gallicchio, Steven N, Fraley, Mark E, Bell, Ian M, Ginnetti, Anthony, Staas, Donnette D, Wang, Cheng, Mitchell, Helen J, Paone, Daniel V, Zartman, C. Blair
Year of Publication 14.01.2021
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Year of Publication 14.01.2021
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PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS
Gallicchio, Steven N, Fraley, Mark E, Bell, Ian M, Ginnetti, Anthony, Staas, Donnette D, Wang, Cheng, Mitchell, Helen J, Paone, Daniel V, Zartman, C. Blair
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Year of Publication 12.09.2019
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Piperidinone carboxamide azaindane CGRP receptor antagonists
Gallicchio, Steven N, Fraley, Mark E, Bell, Ian M, Staas, Donnette D, Wang, Cheng, Ginetti, Anthony, Mitchell, Helen J, Paone, Daniel V, Zartman, C. Blair
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Year of Publication 30.04.2019
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COMPOSTO, COMPOSIÇÃO FARNMACÊUTICA, E, USO DO COMPOSTO
IAN M. BELL, CHENG WANG, MARK E. FRALEY, HELEN J. MITCHELL, HEATHER E. STEVENSON, C. BLAIR ZARTMAN, DANIEL V. PAONE, STEVEN N. GALLICCHIO, ANTHONY GINNETTI, DONNETTE D. STAAS
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Year of Publication 18.04.2023
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PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS
Fraley Mark E, Gallicchio Steven N, Staas Donnette D, Bell Ian M, Ginetti Anthony, Mitchell Helen J, Paone Daniel V, Wang Cheng, Zartman C. Blair
Year of Publication 05.04.2018
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Year of Publication 05.04.2018
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Piperidinone carboxamide azaindane CGRP receptor antagonists
Fraley Mark E, Gallicchio Steven N, Staas Donnette D, Bell Ian M, Mitchell Helen J, Ginnetti Anthony, Paone Daniel V, Wang Cheng, Zartman C. Blair
Year of Publication 05.12.2017
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Year of Publication 05.12.2017
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