Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities
Teyra, Joan, Huang, Haiming, Jain, Shobhit, Guan, Xinyu, Dong, Aiping, Liu, Yanli, Tempel, Wolfram, Min, Jinrong, Tong, Yufeng, Kim, Philip M., Bader, Gary D., Sidhu, Sachdev S.
Published in Structure (London) (03.10.2017)
Published in Structure (London) (03.10.2017)
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Journal Article
The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain
Min, Jinrong, Xu, Chao, Bian, Chuanbing, Lam, Robert, Dong, Aiping
Published in Nature communications (08.03.2011)
Published in Nature communications (08.03.2011)
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Journal Article
Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4
Liu, Yanli, Qin, Su, Chen, Tsai-Yu, Lei, Ming, Dhar, Shilpa S., Ho, Jolene Caifeng, Dong, Aiping, Loppnau, Peter, Li, Yanjun, Lee, Min Gyu, Min, Jinrong
Published in Nature communications (03.01.2019)
Published in Nature communications (03.01.2019)
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Journal Article
Structure and Biochemical Functions of SIRT6
Pan, Patricia W., Feldman, Jessica L., Devries, Mark K., Dong, Aiping, Edwards, Aled M., Denu, John M.
Published in The Journal of biological chemistry (22.04.2011)
Published in The Journal of biological chemistry (22.04.2011)
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Journal Article
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations
Wu, Hong, Zeng, Hong, Dong, Aiping, Li, Fengling, He, Hao, Senisterra, Guillermo, Seitova, Alma, Duan, Shili, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Schapira, Matthieu
Published in PloS one (19.12.2013)
Published in PloS one (19.12.2013)
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Journal Article
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase
Xiong, Yan, Li, Fengling, Babault, Nicolas, Dong, Aiping, Zeng, Hong, Wu, Hong, Chen, Xin, Arrowsmith, Cheryl H, Brown, Peter J, Liu, Jing, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, DiMaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian
Published in Nature chemical biology (10.07.2011)
Published in Nature chemical biology (10.07.2011)
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Journal Article
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2014)
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Journal Article
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
Nakayama, Kazuhide, Szewczyk, Magdalena M, Dela Sena, Carlo, Wu, Hong, Dong, Aiping, Zeng, Hong, Li, Fengling, de Freitas, Renato Ferreira, Eram, Mohammad S, Schapira, Matthieu, Baba, Yuji, Kunitomo, Mihoko, Cary, Douglas R, Tawada, Michiko, Ohashi, Akihiro, Imaeda, Yasuhiro, Saikatendu, Kumar Singh, Grimshaw, Charles E, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Kiba, Atsushi, Tomita, Daisuke, Brown, Peter J
Published in Oncotarget (06.04.2018)
Published in Oncotarget (06.04.2018)
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Journal Article
Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
Kamps, Jos J.A.G., Huang, Jiaxin, Poater, Jordi, Xu, Chao, Pieters, Bas J.G.E., Dong, Aiping, Min, Jinrong, Sherman, Woody, Beuming, Thijs, Matthias Bickelhaupt, F., Li, Haitao, Mecinović, Jasmin
Published in Nature communications (18.11.2015)
Published in Nature communications (18.11.2015)
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Journal Article
Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP
Liu, Yanli, Lau, Johnathan, Li, Weiguo, Tempel, Wolfram, Li, Li, Dong, Aiping, Narula, Ashrut, Qin, Su, Min, Jinrong
Published in Biochemical journal (15.01.2016)
Published in Biochemical journal (15.01.2016)
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Journal Article
Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)
Getlik, Matthäus, Smil, David, Zepeda-Velázquez, Carlos, Bolshan, Yuri, Poda, Gennady, Wu, Hong, Dong, Aiping, Kuznetsova, Ekaterina, Marcellus, Richard, Senisterra, Guillermo, Dombrovski, Ludmila, Hajian, Taraneh, Kiyota, Taira, Schapira, Matthieu, Arrowsmith, Cheryl H, Brown, Peter J, Vedadi, Masoud, Al-awar, Rima
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3
Zhang, Qi, Harding, Rachel, Hou, Feng, Dong, Aiping, Walker, John R., Bteich, Joseph, Tong, Yufeng
Published in The Journal of biological chemistry (12.08.2016)
Published in The Journal of biological chemistry (12.08.2016)
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Journal Article
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation
Islam, Kabirul, Chen, Yuling, Wu, Hong, Bothwell, Ian R., Blum, Gil J., Zeng, Hong, Dong, Aiping, Zheng, Weihong, Min, Jinrong, Deng, Haiteng, Luo, Minkui
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
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Journal Article
Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9
Wu, Hong, Mathioudakis, Nikolas, Diagouraga, Boubou, Dong, Aiping, Dombrovski, Ludmila, Baudat, Frédéric, Cusack, Stephen, de Massy, Bernard, Kadlec, Jan
Published in Cell reports (Cambridge) (17.10.2013)
Published in Cell reports (Cambridge) (17.10.2013)
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Journal Article
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Journal Article
Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19
Dong, Cheng, Nakagawa, Reiko, Oyama, Kyohei, Yamamoto, Yusuke, Zhang, Weilian, Dong, Aiping, Li, Yanjun, Yoshimura, Yuriko, Kamiya, Hiroyuki, Nakayama, Jun-Ichi, Ueda, Jun, Min, Jinrong
Published in eLife (01.09.2020)
Published in eLife (01.09.2020)
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Journal Article
Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin
Schuetz, Anja, Min, Jinrong, Antoshenko, Tatiana, Wang, Chia-Lin, Allali-Hassani, Abdellah, Dong, Aiping, Loppnau, Peter, Vedadi, Masoud, Bochkarev, Alexey, Sternglanz, Rolf, Plotnikov, Alexander N.
Published in Structure (London) (01.03.2007)
Published in Structure (London) (01.03.2007)
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