An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family
Cegarra, Céline, Cameron, Béatrice, Chaves, Catarina, Dabdoubi, Tarik, Do, Tuan-Minh, Genêt, Bruno, Roudières, Valérie, Shi, Yi, Tchepikoff, Patricia, Lesuisse, Dominique
Published in PloS one (15.09.2022)
Published in PloS one (15.09.2022)
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An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family
Céline Cegarra, Béatrice Cameron, Catarina Chaves, Tarik Dabdoubi, Tuan-Minh Do, Bruno Genêt, Valérie Roudières, Yi Shi, Patricia Tchepikoff, Dominique Lesuisse
Published in PloS one (15.09.2022)
Published in PloS one (15.09.2022)
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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Kurtyka, Magdalena, Wessely, Frank, Bau, Sarah, Ifie, Eseoghene, He, Liqun, de Wit, Nienke M., Pedersen, Alberte Bay Villekjær, Keller, Maximilian, Webber, Caleb, de Vries, Helga E., Ansorge, Olaf, Betsholtz, Christer, De Bock, Marijke, Chaves, Catarina, Brodin, Birger, Nielsen, Morten S., Neuhaus, Winfried, Bell, Robert D., Letoha, Tamás, Meyer, Axel H., Leparc, Germán, Lenter, Martin, Lesuisse, Dominique, Cader, Zameel M., Buckley, Stephen T., Loryan, Irena, Pietrzik, Claus U.
Published in European journal of cell biology (01.06.2024)
Published in European journal of cell biology (01.06.2024)
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Efficient and Modular Synthesis of New Structurally Diverse Functionalized [n]Paracyclophanes by a Ring-Distortion Strategy
Krieger, Jean-Philippe, Ricci, Gino, Lesuisse, Dominique, Meyer, Christophe, Cossy, Janine
Published in Angewandte Chemie International Edition (11.08.2014)
Published in Angewandte Chemie International Edition (11.08.2014)
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Non-Human Primate Blood–Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model
Chaves, Catarina, Do, Tuan-Minh, Cegarra, Céline, Roudières, Valérie, Tolou, Sandrine, Thill, Gilbert, Rocher, Corinne, Didier, Michel, Lesuisse, Dominique
Published in Pharmaceutics (14.10.2020)
Published in Pharmaceutics (14.10.2020)
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Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model
Do, Tuan-Minh, Capdevila, Cécile, Pradier, Laurent, Blanchard, Véronique, Lopez-Grancha, Mati, Schussler, Nathalie, Steinmetz, Anke, Beninga, Jochen, Boulay, Denis, Dugay, Philippe, Verdier, Patrick, Aubin, Nadine, Dargazanli, Gihad, Chaves, Catarina, Genet, Elisabeth, Lossouarn, Yves, Loux, Christophe, Michoux, François, Moindrot, Nicolas, Chanut, Franck, Gury, Thierry, Eyquem, Stéphanie, Valente, Delphine, Bergis, Olivier, Rao, Ercole, Lesuisse, Dominique
Published in Molecular therapy. Methods & clinical development (11.12.2020)
Published in Molecular therapy. Methods & clinical development (11.12.2020)
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Peptidomics of Haemonchus contortus
Buzy, Armelle, Allain, Camille, Harrington, John, Lesuisse, Dominique, Mikol, Vincent, Bruhn, David F, Maule, Aaron G, Guillemot, Jean-Claude
Published in ACS omega (20.04.2021)
Published in ACS omega (20.04.2021)
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Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease
Malanda, André, Abécassis, Pierre-Yves, Barnéoud, Pascal, Brunel, Pascale, Taupin, Véronique, Vigé, Xavier, Lesuisse, Dominique
Published in Data in brief (01.12.2019)
Published in Data in brief (01.12.2019)
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Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles
Nemecek, Conception, Metz, William A., Wentzler, Sylvie, Ding, Fa-Xiang, Venot, Corinne, Souaille, Catherine, Dagallier, Anne, Maignan, Sébastien, Guilloteau, Jean-Pierre, Bernard, François, Henry, Alain, Grapinet, Sandrine, Lesuisse, Dominique
Published in Chemical biology & drug design (01.08.2010)
Published in Chemical biology & drug design (01.08.2010)
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SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2
Lesuisse, Dominique, Lange, Gudrun, Deprez, Pierre, Bénard, Didier, Schoot, Bernard, Delettre, Georges, Marquette, Jean-Pierre, Broto, Pierre, Jean-Baptiste, Véronique, Bichet, Paulette, Sarubbi, Edoardo, Mandine, Eliane
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Rhodium(III)-Catalyzed C–H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones
Krieger, Jean-Philippe, Lesuisse, Dominique, Ricci, Gino, Perrin, Marc-Antoine, Meyer, Christophe, Cossy, Janine
Published in Organic letters (19.05.2017)
Published in Organic letters (19.05.2017)
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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus
Published in Pharmaceutical research (01.07.2022)
Published in Pharmaceutical research (01.07.2022)
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Journal Article
Harnessing C−H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones
Krieger, Jean-Philippe, Ricci, Gino, Lesuisse, Dominique, Meyer, Christophe, Cossy, Janine
Published in Chemistry : a European journal (12.09.2016)
Published in Chemistry : a European journal (12.09.2016)
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Journal Article
Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus
Published in Pharmaceutical research (2022)
Published in Pharmaceutical research (2022)
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Journal Article
New formats for improving brain drug delivery of antibodies: the blood-brain barrier case
Lafaye, Pierre, Lesuisse, Dominique, Declèves, Xavier
Published in M.S. Médecine sciences (06.01.2020)
Published in M.S. Médecine sciences (06.01.2020)
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Journal Article
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease
Lesuisse, Dominique, Malanda, André, Peyronel, Jean-François, Evanno, Yannick, Lardenois, Patrick, De-Peretti, Danielle, Abécassis, Pierre-Yves, Barnéoud, Pascal, Brunel, Pascale, Burgevin, Marie-Claude, Cegarra, Céline, Auger, Florian, Dommergue, Amélie, Lafon, Corinne, Even, Luc, Tsi, Joanna, Luc, Thy Phuong Hieu, Almario, Antonio, Olivier, Anne, Castel, Marie-Noëlle, Taupin, Véronique, Rooney, Thomas, Vigé, Xavier
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
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