H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma
Joshi, Jaya Julie, Coffey, Heather, Corcoran, Erik, Tsai, Jennifer, Huang, Chia-Ling, Ichikawa, Kana, Prajapati, Sudeep, Hao, Ming-Hong, Bailey, Suzanna, Wu, Jeremy, Rimkunas, Victoria, Karr, Craig, Subramanian, Vanitha, Kumar, Pavan, MacKenzie, Crystal, Hurley, Raelene, Satoh, Takashi, Yu, Kun, Park, Eunice, Rioux, Nathalie, Kim, Amy, Lai, Weidong G, Yu, Lihua, Zhu, Ping, Buonamici, Silvia, Larsen, Nicholas, Fekkes, Peter, Wang, John, Warmuth, Markus, Reynolds, Dominic J, Smith, Peter G, Selvaraj, Anand
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
Finci, Lorenzo I, Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G, Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A
Published in Genes & development (01.02.2018)
Published in Genes & development (01.02.2018)
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Reprogramming RNA processing: an emerging therapeutic landscape
Neil, Christopher R., Seiler, Michael W., Reynolds, Dominic J., Smith, Jesse J., Vaillancourt, Frédéric H., Smith, Peter G., Agrawal, Anant A.
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
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Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Gunzner-Toste, Janet, Liederer, Bianca M, Ly, Justin, O’Brien, Thomas, Oh, Angela, Wang, Leslie, Wang, Weiru, Xiao, Yang, Zak, Mark, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Gunzner-Toste, Janet, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Zheng, Xiaozhang, Bair, Kenneth W., Bauer, Paul, Baumeister, Timm, Bowman, Krista K., Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Feng, Yezhen, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Li, Hong, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Ly, Justin, O’Brien, Thomas, Oeh, Jason, Oh, Angela, Reynolds, Dominic J., Sampath, Deepak, Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Tremayne, Jarrod, Wang, Leslie, Wang, Weiru, Wang, Zhongguo, Wu, Hongxing, Wu, Jiansheng, Xiao, Yang, Yang, Guangxing, Yuen, Po-wai, Zak, Mark, Dragovich, Peter S.
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
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Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Zheng, Xiaozhang, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J., Sharma, Geeta, Smith, Chase C., Wang, Zhongguo, Dragovich, Peter S., Oh, Angela, Wang, Weiru, Zak, Mark, Wang, Yunli, Yuen, Po-wai, Bair, Kenneth W.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905)
Duffey, Matthew O, Vos, Tricia J, Adams, Ruth, Alley, Jennifer, Anthony, Justin, Barrett, Cynthia, Bharathan, Indu, Bowman, Douglas, Bump, Nancy J, Chau, Ryan, Cullis, Courtney, Driscoll, Denise L, Elder, Amy, Forsyth, Nancy, Frazer, Jonathan, Guo, Jianping, Guo, Luyi, Hyer, Marc L, Janowick, David, Kulkarni, Bheemashankar, Lai, Su-Jen, Lasky, Kerri, Li, Gang, Li, Jing, Liao, Debra, Little, Jeremy, Peng, Bo, Qian, Mark G, Reynolds, Dominic J, Rezaei, Mansoureh, Scott, Margaret Porter, Sells, Todd B, Shinde, Vaishali, Shi, Qiuju Judy, Sintchak, Michael D, Soucy, Francois, Sprott, Kevin T, Stroud, Stephen G, Nestor, Michelle, Visiers, Irache, Weatherhead, Gabriel, Ye, Yingchun, D’Amore, Natalie
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility
Zak, Mark, Liederer, Bianca M., Sampath, Deepak, Yuen, Po-wai, Bair, Kenneth W., Baumeister, Timm, Buckmelter, Alexandre J., Clodfelter, Karl H., Cheng, Eric, Crocker, Lisa, Fu, Bang, Han, Bingsong, Li, Guangkun, Ho, Yen-Ching, Lin, Jian, Liu, Xiongcai, Ly, Justin, O’Brien, Thomas, Reynolds, Dominic J., Skelton, Nicholas, Smith, Chase C., Tay, Suzanne, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Dragovich, Peter S.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Mukadam, Sophie, O’Brien, Thomas, Oh, Angela, Reynolds, Dominic J., Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Sodhi, Jasleen, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang, Bair, Kenneth W., Dragovich, Peter S.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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In vitro sensitivities to UVA of lymphocytes from patients with colon and melanoma cancers and precancerous states in the micronucleus and the Comet assays
NAJAFZADEH, Mojgan, BAUMGARTNER, Adolf, GOPALAN, Rajendran, DAVIES, Justin B, WRIGHT, Andrew, DOMINIC REYNOLDS, P, ANDERSON, Diana
Published in Mutagenesis (01.05.2012)
Published in Mutagenesis (01.05.2012)
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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer
Puyang, Xiaoling, Furman, Craig, Zheng, Guo Zhu, Wu, Zhenhua J, Banka, Deepti, Aithal, Kiran, Agoulnik, Sergei, Bolduc, David M, Buonamici, Silvia, Caleb, Benjamin, Das, Subhasree, Eckley, Sean, Fekkes, Peter, Hao, Ming-Hong, Hart, Andrew, Houtman, René, Irwin, Sean, Joshi, Jaya J, Karr, Craig, Kim, Amy, Kumar, Namita, Kumar, Pavan, Kuznetsov, Galina, Lai, Weidong G, Larsen, Nicholas, Mackenzie, Crystal, Martin, Lesley-Ann, Melchers, Diana, Moriarty, Alyssa, Nguyen, Tuong-Vi, Norris, John, O'Shea, Morgan, Pancholi, Sunil, Prajapati, Sudeep, Rajagopalan, Sujatha, Reynolds, Dominic J, Rimkunas, Victoria, Rioux, Nathalie, Ribas, Ricardo, Siu, Amy, Sivakumar, Sasirekha, Subramanian, Vanitha, Thomas, Michael, Vaillancourt, Frédéric H, Wang, John, Wardell, Suzanne, Wick, Michael J, Yao, Shihua, Yu, Lihua, Warmuth, Markus, Smith, Peter G, Zhu, Ping, Korpal, Manav
Published in Cancer discovery (01.09.2018)
Published in Cancer discovery (01.09.2018)
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Enantioselective Synthesis of Oasomycin A, Part III: Fragment Assembly and Confirmation of Structure
Evans, David A., Nagorny, Pavel, McRae, Kenneth J., Sonntag, Louis-Sebastian, Reynolds, Dominic J., Vounatsos, Filisaty
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Journal Article
1,2-Diacetals: A New Opportunity for Organic Synthesis
Ley, Steven V, Baeschlin, Daniel K, Dixon, Darren J, Foster, Alison C, Ince, Stuart J, Priepke, Henning W. M, Reynolds, Dominic J
Published in Chemical reviews (01.01.2001)
Published in Chemical reviews (01.01.2001)
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Journal Article
Enantioselective Synthesis of Oasomycin A, Part I: Synthesis of the C1-C12 and C13-C28 Subunits
Evans, David A., Nagorny, Pavel, McRae, Kenneth J., Reynolds, Dominic J., Sonntag, Louis-Sebastian, Vounatsos, Filisaty, Xu, Risheng
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C
Dixon, Darren J., Ley, Steven V., Reynolds, Dominic J.
Published in Chemistry : a European journal (02.04.2002)
Published in Chemistry : a European journal (02.04.2002)
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Journal Article
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C
Dixon, Darren J., Ley, Steven V., Reynolds, Dominic J.
Published in Angewandte Chemie International Edition (16.10.2000)
Published in Angewandte Chemie International Edition (16.10.2000)
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Sensitivity and specificity of the empirical lymphocyte genome sensitivity (LGS) assay: implications for improving cancer diagnostics
Anderson, Diana, Najafzadeh, Mojgan, Gopalan, Rajendran, Ghaderi, Nader, Scally, Andrew J, Britland, Stephen T, Jacobs, Badie K, Reynolds, P Dominic, Davies, Justin, Wright, Andrew L, Al-Ghazal, Shariff, Sharpe, David, Denyer, Morgan C
Published in The FASEB journal (01.10.2014)
Published in The FASEB journal (01.10.2014)
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