CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Hernandez-Cedeño, M., Venegas-Rodriguez, R., Peña-Ruiz, R., Bequet-Romero, M., Santana-Sanchez, R., Penton-Arias, E., Martinez-Donato, G., Guillén-Nieto, G., del Carmen Dominguez-Horta, María
Published in Cell stress & chaperones (01.05.2021)
Published in Cell stress & chaperones (01.05.2021)
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Journal Article
Jusvinza, an anti-inflammatory drug derived from the human heat-shock protein 60, for critically ill COVID-19 patients. An observational study
Venegas-Rodríguez, Rafael, Serrano-Díaz, Anabel, Peña-Ruiz, Ruben, Santana-Sánchez, Raul, Hernández-Cedeño, Mabel, Rittoles Navarro, Aliusha, Grecesqui-Cruz, Inti, Pérez-Aguilera, Liam, Segura-Fernández, Anadys, Rosario-Cruz, Leticia, Martínez-Donato, Gilliam, Guillén-Nieto, Gerardo, Domínguez-Horta, Maria Del Carmen
Published in PloS one (02.02.2023)
Published in PloS one (02.02.2023)
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Journal Article
CIGB-258 Exerts Potent Anti-Inflammatory Activity against Carboxymethyllysine-Induced Acute Inflammation in Hyperlipidemic Zebrafish via the Protection of Apolipoprotein A-I
Cho, Kyung-Hyun, Nam, Hyo-Seon, Kim, Ji-Eun, Na, Hye-Jee, Del Carmen Dominguez-Horta, Maria, Martinez-Donato, Gillian
Published in International journal of molecular sciences (01.04.2023)
Published in International journal of molecular sciences (01.04.2023)
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Journal Article
Synergistic Anti-Inflammatory Activity of Lipid-Free Apolipoprotein (apo) A-I and CIGB-258 in Acute-Phase Zebrafish via Stabilization of the apoA-I Structure to Enhance Anti-Glycation and Antioxidant Activities
Cho, Kyung-Hyun, Bahuguna, Ashutosh, Lee, Yunki, Lee, Sang Hyuk, Dominguez-Horta, Maria Del Carmen, Martinez-Donato, Gillian
Published in International journal of molecular sciences (20.05.2024)
Published in International journal of molecular sciences (20.05.2024)
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Journal Article
A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation
Domínguez-Horta, Maria Del Carmen, Serrano-Díaz, Anabel, Hernández-Cedeño, Mabel, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo
Published in Frontiers in immunology (28.04.2023)
Published in Frontiers in immunology (28.04.2023)
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Journal Article
Synergistic Anti-Inflammatory Activity of Apolipoprotein A-I and CIGB-258 in Reconstituted High-Density Lipoproteins (rHDL) against Acute Toxicity of Carboxymethyllysine in Zebrafish and Its Embryo
Cho, Kyung-Hyun, Kim, Ji-Eun, Kang, Dae-Jin, Dominguez-Horta, Maria Del Carmen, Martinez-Donato, Gillian
Published in Pharmaceuticals (Basel, Switzerland) (28.01.2024)
Published in Pharmaceuticals (Basel, Switzerland) (28.01.2024)
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Journal Article
BioHabana 2022: Preventive and Immunotherapeutic Strategies Against COVID-19 and Cancer in Cuba
Bello-Rivero, Iraldo, Crombet-Ramos, Tania, Mesa-Pardillo, Circe, Morera-Díaz, Yanelys, Mazorra-Herrera, Zaima, Garcia-Rivera, Dagmar, Nodarse-Cuní, Hugo, Hernández-Bernal, Francisco, Muzio-Gonzalez, Verena, Aguilera-Barreto, Ana, Vazquez-Blomquist, Dania, Domínguez-Horta, Maria Del Carmen, Guillen-Nieto, Gerardo
Published in Journal of interferon & cytokine research (01.12.2023)
Published in Journal of interferon & cytokine research (01.12.2023)
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Journal Article
CIGB-814, an altered peptide ligand derived from human heat-shock protein 60, decreases anti-cyclic citrullinated peptides antibodies in patients with rheumatoid arthritis
Corrales, Oreste, Hernández, Laura, Prada, Dinorah, Gómez, Jorge, Reyes, Yusimy, López, Ana Marta, González, Luis Javier, del Carmen Domínguez Horta, Maria
Published in Clinical rheumatology (01.03.2019)
Published in Clinical rheumatology (01.03.2019)
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Journal Article
CIGB-258, péptido inhibidor de la hiperinflamación en pacientes con COVID-19
María del Carmen Domínguez Horta, Rafael Venegas Rodríguez, Gerardo Guillén Nieto, Gillian Martínez Donato, Mabel Hernández Cedeño, Mónica Bequet Romero, Rubén Peña Ruiz, Raúl Santana Sánchez, Luis Javier González, Ania Cabrales, Gabriel Padrón, Leticia Rosario Cruz, Idelsis Esquivel Moynelo
Published in Anales de la Academia de Ciencias de Cuba (01.01.2022)
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Published in Anales de la Academia de Ciencias de Cuba (01.01.2022)
Journal Article
Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study
Cimino, Rita, Savioli, Marco, Carrante, Noemi Ferrante, Placidi, Ernesto, Garay-Perez, Hilda, López-Abad, Matilde, Lasa, Alexis Musacchio, Domínguez-Horta, Maria Del Carmen, Gatto, Emanuela, Cavalieri, Francesca, Bocchinfuso, Gianfranco, Venanzi, Mariano
Published in ChemPhysMater (01.01.2022)
Published in ChemPhysMater (01.01.2022)
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Journal Article
Enhancing Wound Healing and Anti-Inflammatory Effects by Combination of CIGB-258 and Apolipoprotein A-I against Carboxymethyllysine Toxicity in Zebrafish: Insights into Structural Stabilization and Antioxidant Properties
Cho, Kyung-Hyun, Lee, Yunki, Lee, Sang Hyuk, Kim, Ji-Eun, Bahuguna, Ashutosh, Dominguez-Horta, Maria del Carmen, Martinez-Donato, Gillian
Published in Antioxidants (28.08.2024)
Published in Antioxidants (28.08.2024)
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Journal Article
Compassionate use of Jusvinza in the treatment of a patient with severe Leptospirosis associated with the Jarisch Herxeimer reaction
Ruben Manuel Peña Ruiz, Rafael Venegas Rodriguez, Raul Santana Sánchez, Beatriz Mary Santiesteban Licea, Aliusha Rittoles Navarro, Liam Manuel Pérez Aguilera, Alejandro Rittoles Navarro, Alejandro Ávila Galano, Maria del Carmen Dominguez Horta
Published in Revista cubana de medicina militar (01.07.2024)
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Published in Revista cubana de medicina militar (01.07.2024)
Journal Article
The treatment with Jusvinza reduces hyperinflammation and hypercoagulation in critical ill patients with COVID-19
Rafael Venegas Rodríguez, Anabel Serrano Díaz, Rubén Peña Ruiz, Raúl Santana Sánchez, Aliusha Rittoles Navarro, Inti Grecesqui Cruz, Liam Manuel Pérez Aguilera, Anadys Segura Fernández, Mabel Hernández-Cedeño, Leticia Rosario Cruz, Deyli Chacón Montano, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta
Published in Revista cubana de medicina militar (01.11.2021)
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Published in Revista cubana de medicina militar (01.11.2021)
Journal Article
The treatment with Jusvinza reduces hyperinflammation and hypercoagulation in critical ill patients with COVID-19
Rafael Venegas Rodríguez, Anabel Serrano Díaz, Rubén Peña Ruiz, Raúl Santana Sánchez, Aliusha Rittoles Navarro, Inti Grecesqui Cruz, Liam Manuel Pérez Aguilera, Anadys Segura Fernández, Mabel Hernández-Cedeño, Leticia Rosario Cruz, Deyli Chacón Montano, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta
Published in Revista cubana de medicina militar (01.11.2021)
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Published in Revista cubana de medicina militar (01.11.2021)
Journal Article
CIGB-258 immunomodulatory peptide for the treatment of critical and severe COVID-19 patients
Rafael Venegas Rodríguez, Rubén Peña Ruiz, Raúl Santana Sánchez, Mónica Bequet-Romero, Mabel Hernández-Cedeño, Beatriz Santiesteban Licea, Ariana García, Pedro Rafel Aroche de Dios, Daniela Oliva Pérez, Leticia Rosario Cruz, Idelsis Esquivel Moynelo, Maura García Sánchez, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta
Published in Revista cubana de medicina militar (01.10.2020)
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Published in Revista cubana de medicina militar (01.10.2020)
Journal Article
Comportamiento de la actividad clínica y la respuesta al tratamiento en pacientes con artritis reumatoide tratados con Jusvinza
Pozo Abreu, Silvia Maria, Ruiz Vaquero, Rene, Domínguez Horta, María del Carmen, Prada Hernández, Dinorah Marisabel, Ordaz Acosta, Arisel, Molinero Rodríguez, Claudino, Reyes Pineda, Yusimí, Gómez Morejón, Jorge Alexis
Published in Revista cubana de reumatología (2023)
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Published in Revista cubana de reumatología (2023)
Journal Article
Phase I Clinical Trial with a Novel Altered Peptide Ligand Derived from Human Heat-Shock Protein 60 for Treatment of Rheumatoid Arthritis: Safety, Pharmacokinetics and Preliminary Therapeutic Effects
Prada, Dinorah, Gomez, Jorge, Lorenzo, Norailys, Corrales, Oreste, Lopez, Ana, Gonzalez, Evelio, Cabrales, Ania, Reyes, Yusimy, Bermudez, Yuliet, Avila, Yisel, Perez, Lina, Molinero, Claudio, Martinez, Osmel, Oramas, Leonardo, Minoso, Yaysel, Ramos, Yassel, Garay, Hilda, Perez, Ever, Lopez, Matilde, Reyes, Osvaldo, Cruz, Yolanda, Hernandez, Alfredo, Carlos, Cabal, Besada, Vladimir, Gonzalez, Luis Javier, Padron, Gabriel, Dominguez Horta, Maria del Carmen
Published in Journal of clinical trials (2018)
Published in Journal of clinical trials (2018)
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Journal Article
사이토카인 폭풍 증후군의 치료를 위한 펩타이드
DOMINGUEZ HORTA MARIA DEL CARMEN, VENEGAS RODRIGUEZ RAFAEL, ORTEGA GONZALEZ LILIA MARIA, NODARSE CUNI HUGO, GARAY PEREZ HILDA ELISA, UBIETA GOMEZ RAIMUNDO, GUILLEN NIETO GERARDO ENRIQUE, MARTINEZ DONATO GILLIAN, LOPEZ ABAD CRUZ MATILDE, HERNANDEZ CEDENO MABEL
Year of Publication 20.12.2022
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Year of Publication 20.12.2022
Patent
APL 형 펩타이드를 포함하는 약제학적 조성물
DOMINGUEZ HORTA MARIA DEL CARMEN, BESADA PEREZ VLADIMIR ARMANDO, GONZALEZ LOPEZ LUIS JAVIER, LOPEZ ABAD CRUZ MATILDE
Year of Publication 09.09.2020
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Year of Publication 09.09.2020
Patent