Discovery of N-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1) Receptor Antagonist
Hodgetts, Kevin J, Ge, Ping, Yoon, Taeyoung, Lombaert, Stéphane De, Brodbeck, Robbin, Gulianello, Michael, Kieltyka, Andrzej, Horvath, Raymond F, Kehne, John H, Krause, James E, Maynard, George D, Hoffman, Diane, Lee, Younglim, Fung, Laurence, Doller, Dario
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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Journal Article
Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist
Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Journal Article
Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia
Bennouar, Khaled-Ezaheir, Uberti, Michelle A., Melon, Christophe, Bacolod, Maria D., Jimenez, Hermogenes N., Cajina, Manuel, Kerkerian-Le Goff, Lydia, Doller, Darío, Gubellini, Paolo
Published in Neuropharmacology (01.03.2013)
Published in Neuropharmacology (01.03.2013)
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Journal Article
The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies
Wierońska, Joanna M., Sławińska, Anna, Łasoń-Tyburkiewicz, Magdalena, Gruca, Piotr, Papp, Mariusz, Zorn, Stevin H., Doller, Darío, Kłeczek, Natalia, Noworyta-Sokołowska, Karolina, Gołembiowska, Krystyna, Pilc, Andrzej
Published in Psychopharmacology (01.01.2015)
Published in Psychopharmacology (01.01.2015)
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A case study of foliglurax, the first clinical mGluR4 PAM for symptomatic treatment of Parkinson's disease: translational gaps or a failing industry innovation model?
Doller, Dario, Bespalov, Anton, Miller, Rob, Pietraszek, Malgorzata, Kalinichev, Mikhail
Published in Expert opinion on investigational drugs (01.12.2020)
Published in Expert opinion on investigational drugs (01.12.2020)
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Journal Article
Recent Developments in Group I Metabotropic Glutamate Receptor Allosteric Modulators for the Treatment of Psychiatric and Neurological Disorders (2014-May 2015)
Li, Guiying, Jorgensen, Morten, Campbell, Brian M, Doller, Dario
Published in Current topics in medicinal chemistry (01.12.2016)
Published in Current topics in medicinal chemistry (01.12.2016)
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Journal Article
Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators
Hong, Sang-Phyo, Liu, Kevin G, Ma, Gil, Sabio, Michael, Uberti, Michelle A, Bacolod, Maria D, Peterson, John, Zou, Zack Z, Robichaud, Albert J, Doller, Darío
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Journal Article
Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles
Meegalla, Sanath K., Doller, Dario, Liu, Ruiping, Sha, DeYou, Lee, YuKai, Soll, Richard M., Wisnewski, Nancy, Silver, Gary M., Dhanoa, Dale
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
Quality of Research Tools
Doller, Dario, Wes, Paul
Published in Good Research Practice in Non-Clinical Pharmacology and Biomedicine (2020)
Published in Good Research Practice in Non-Clinical Pharmacology and Biomedicine (2020)
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Book Chapter
Journal Article
5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): synthesis and characterization of a novel and selective insect GABA receptor radioligand
Meegalla, Sanath K, Doller, Dario, Silver, Gary M, Wisnewski, Nancy, Soll, Richard M, Dhanoa, Dale
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents
Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Journal Article
Potent, low molecular weight thrombin receptor antagonists
Chackalamannil, Samuel, Doller, Darı́o, Eagen, Keith, Czarniecki, Michael, Ahn, Ho-Sam, Foster, Carolyn J., Boykow, George
Published in Bioorganic & medicinal chemistry letters (05.11.2001)
Published in Bioorganic & medicinal chemistry letters (05.11.2001)
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Journal Article
Drug Design Strategies for GPCR Allosteric Modulators
Conn, P Jeffrey, Kuduk, Scott D, Doller, Darío
Published in Annual reports in medicinal chemistry (2012)
Published in Annual reports in medicinal chemistry (2012)
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Journal Article
Discovery and structure–activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators
Zhou, Hao, Topiol, Sidney W., Grenon, Michel, Jimenez, Hermogenes N., Uberti, Michelle A., Smith, Daniel G., Brodbeck, Robbin M., Chandrasena, Gamini, Pedersen, Henrik, Madsen, Jens Christian, Doller, Darío, Li, Guiying
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
Jimenez, Hermogenes N., Liu, Kevin G., Hong, Sang-Phyo, Reitman, Michael S., Uberti, Michelle A., Bacolod, Maria D., Cajina, Manuel, Nattini, Megan, Sabio, Michael, Doller, Darío
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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