Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)
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Published in Journal of medicinal chemistry (09.10.2008)
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High-performance liquid chromatographic enantioseparation of methanobenzazocines
Barker, William M., Worm, Karin, Dolle, Roland E.
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Published in Journal of Chromatography A (06.11.2009)
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Nascent structure–activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208
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Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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General and efficient synthetic approach to novel tricyclic spiroketones
Chu, Guo-Hua, Le Bourdonnec, Bertrand, Gu, Minghua, Saeui, Christopher T., Dolle, Roland E.
Published in Tetrahedron (04.07.2009)
Published in Tetrahedron (04.07.2009)
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Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists
CHU, Guo-Hua, SAEUI, Christopher T, BROGDON, Bernice, SMITH, Steve, LE BOURDONNEC, Bertrand, DOLLE, Roland E, WORM, Karin, WEAVER, Damian G, GOODMAN, Allan J, BROADRUP, Robert L, CASSE, Joel A, DEHAVEN, Robert N, LABUDA, Christopher J, KOBLISH, Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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CB2 selective sulfamoyl benzamides : Optimization of the amide functionality
GOODMAN, Allan J, AJELLO, Christopher W, KOBLISH, Michael, LITTLE, Patrick J, BROGDON, Bernice L, SMITH, Steven A, DOLLE, Roland E, WORM, Karin, LE BOURDONNEC, Bertrand, SAVOLAINEN, Markku A, O'HARE, Heather, CASSEL, Joel A, STABLEY, Gabriel J, DEHAVEN, Robert N, LABUDA, Christopher J
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Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Synthesis and Pharmacological Evaluation of Novel Octahydro-1H-pyrido[1,2-a]pyrazine as μ-Opioid Receptor Antagonists
Le Bourdonnec, Bertrand, Goodman, Allan J, Graczyk, Thomas M, Belanger, Serge, Seida, Pamela R, DeHaven, Robert N, Dolle, Roland E
Published in Journal of medicinal chemistry (14.12.2006)
Published in Journal of medicinal chemistry (14.12.2006)
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Novel malonamide derivatives as potent κ opioid receptor agonists
Chu, Guo-Hua, Gu, Minghua, Cassel, Joel A., Belanger, Serge, Graczyk, Thomas M., DeHaven, Robert N., Conway-James, Nathalie, Koblish, Michael, Little, Patrick J., DeHaven-Hudkins, Diane L., Dolle, Roland E.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands
WORM, Karin, ZHOU, Q. Jean, LITTLE, Patrick J, DOLLE, Roland E, SAEUI, Christopher T, GREEN, Rosalyn C, CASSEL, Joel A, STABLEY, Gabriel J, DEHAVEN, Robert N, CONWAY-JAMES, Nathalie, LABUDA, Christopher J, KOBLISH, Michael
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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Elucidation of the Bioactive Conformation of the N-Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Class of μ-Opioid Receptor Antagonists
Le Bourdonnec, Bertrand, Goodman, Allan J, Michaut, Mathieu, Ye, Hai-Fen, Graczyk, Thomas M, Belanger, Serge, Herbertz, Torsten, Yap, Glenn P. A, DeHaven, Robert N, Dolle, Roland E
Published in Journal of medicinal chemistry (14.12.2006)
Published in Journal of medicinal chemistry (14.12.2006)
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Novel sulfamoyl benzamides as selective CB2 agonists with improved in vitro metabolic stability
SELLITTO, Ian, LE BOURDONNEC, Bertrand, DEHAVEN, Robert N, LABUDA, Christopher J, KOBLISH, Michael, LITTLE, Patrick J, BROGDON, Bernice L, SMITH, Steven A, DOLLE, Roland E, WORM, Karin, GOODMAN, Allan, SAVOLAINEN, Markku A, CHU, Guo-Hua, AJELLO, Christopher W, SAEUI, Christopher T, LEISTER, Lara K, CASSEL, Joel A
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists
WORM, Karin, WEAVER, Damian G, KOBLISH, Michael, BROGDON, Bernice L, SMITH, Steven A, DOLLE, Roland E, GREEN, Rosalyn C, SAEUI, Christopher T, DULAY, Doreen-Marie S, BARKER, William M, CASSEL, Joel A, STABLEY, Gabriel J, DEHAVEN, Robert N, LABUDA, Christopher J
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Biaryl cannabinoid mimetics—Synthesis and structure–activity relationship
Worm, Karin, Zhou, Q. Jean, Stabley, Gabriel J., DeHaven, Robert N., Dolle, Roland E.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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5,7-Dimethoxy-3-(4-Pyridinyl)Quinoline Is a Potent and Selective Inhibitor of Human Vascular .beta.-Type Platelet-Derived Growth Factor Receptor Tyrosine Kinase
Dolle, Roland E, Dunn, Joseph A, Bobko, Mark, Singh, Baldev, Kuster, Joan E, Baizman, Eugene, Harris, Alex L, Sawutz, David G, Miller, Deborah, Wang, Su, Faltynek, Connie R, Xie, Wen, Sarup, Jay, Bode, D. Christopher, Pagani, Edward D, Silver, Paul J
Published in Journal of medicinal chemistry (19.08.1994)
Published in Journal of medicinal chemistry (19.08.1994)
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