Brexanolone as adjunctive therapy in super‐refractory status epilepticus
Rosenthal, Eric S., Claassen, Jan, Wainwright, Mark S., Husain, Aatif M., Vaitkevicius, Henrikas, Raines, Shane, Hoffmann, Ethan, Colquhoun, Helen, Doherty, James J., Kanes, Stephen J.
Published in Annals of neurology (01.09.2017)
Published in Annals of neurology (01.09.2017)
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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Wong, Man Ying, Lewis, Michael, Doherty, James J, Shi, Yang, Cashikar, Anil G, Amelianchik, Anna, Tymchuk, Svitlana, Sullivan, Patrick M, Qian, Mingxing, Covey, Douglas F, Petsko, Gregory A, Holtzman, David M, Paul, Steven M, Luo, Wenjie
Published in Journal of neuroinflammation (17.06.2020)
Published in Journal of neuroinflammation (17.06.2020)
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Stimulus-specific adaptation in auditory cortex is an NMDA-independent process distinct from the sensory novelty encoded by the mismatch negativity
Farley, Brandon J, Quirk, Michael C, Doherty, James J, Christian, Edward P
Published in The Journal of neuroscience (08.12.2010)
Published in The Journal of neuroscience (08.12.2010)
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Trial of SAGE-217 in Patients with Major Depressive Disorder
Gunduz-Bruce, Handan, Silber, Christopher, Kaul, Inder, Rothschild, Anthony J, Riesenberg, Robert, Sankoh, Abdul J, Li, Haihong, Lasser, Robert, Zorumski, Charles F, Rubinow, David R, Paul, Steven M, Jonas, Jeffrey, Doherty, James J, Kanes, Stephen J
Published in The New England journal of medicine (05.09.2019)
Published in The New England journal of medicine (05.09.2019)
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Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N -Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning
Izumi, Yukitoshi, Mennerick, Steven J, Doherty, James J, Zorumski, Charles F
Published in The Journal of pharmacology and experimental therapeutics (01.04.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2021)
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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator
Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.
Published in Neuropharmacology (15.12.2020)
Published in Neuropharmacology (15.12.2020)
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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA A receptor positive allosteric modulator
Althaus, Alison L, Ackley, Michael A, Belfort, Gabriel M, Gee, Steven M, Dai, Jing, Nguyen, David P, Kazdoba, Tatiana M, Modgil, Amit, Davies, Paul A, Moss, Stephen J, Salituro, Francesco G, Hoffmann, Ethan, Hammond, Rebecca S, Robichaud, Albert J, Quirk, Michael C, Doherty, James J
Published in Neuropharmacology (15.12.2020)
Published in Neuropharmacology (15.12.2020)
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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor
Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Blanco, Maria-Jesus, Belfort, Gabriel M, Dai, Jing, Loya, Carlos M, Ackley, Michael A, Althaus, Alison L, Grossman, Scott J, Hoffmann, Ethan, Doherty, James J, Robichaud, Albert J
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors
Paul, Steven M, Doherty, James J, Robichaud, Albert J, Belfort, Gabriel M, Chow, Brian Y, Hammond, Rebecca S, Crawford, Devon C, Linsenbardt, Andrew J, Shu, Hong-Jin, Izumi, Yukitoshi, Mennerick, Steven J, Zorumski, Charles F
Published in The Journal of neuroscience (30.10.2013)
Published in The Journal of neuroscience (30.10.2013)
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Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism
Modgil, Amit, Parakala, Manasa L., Ackley, Michael A., Doherty, James J., Moss, Stephen J., Davies, Paul A.
Published in Neuropharmacology (01.02.2017)
Published in Neuropharmacology (01.02.2017)
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AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study
Litman, Robert E, Smith, Mark A, Doherty, James J, Cross, Alan, Raines, Shane, Gertsik, Lev, Zukin, Stephen R
Published in Schizophrenia research (01.04.2016)
Published in Schizophrenia research (01.04.2016)
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SAGE-718: A First-in-Class N‑Methyl‑d‑Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment
Hill, Matthew D., Blanco, Maria-Jesus, Salituro, Francesco G., Bai, Zhu, Beckley, Jacob T., Ackley, Michael A., Dai, Jing, Doherty, James J., Harrison, Boyd L., Hoffmann, Ethan C., Kazdoba, Tatiana M., Lanzetta, David, Lewis, Michael, Quirk, Michael C., Robichaud, Albert J.
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA A receptors
Parakala, Manasa L, Zhang, Yihui, Modgil, Amit, Chadchankar, Jayashree, Vien, Thuy N, Ackley, Michael A, Doherty, James J, Davies, Paul A, Moss, Stephen J
Published in The Journal of biological chemistry (09.08.2019)
Published in The Journal of biological chemistry (09.08.2019)
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Journal Article
Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors
Parakala, Manasa L., Zhang, Yihui, Modgil, Amit, Chadchankar, Jayashree, Vien, Thuy N., Ackley, Michael A., Doherty, James J., Davies, Paul A., Moss, Stephen J.
Published in The Journal of biological chemistry (09.08.2019)
Published in The Journal of biological chemistry (09.08.2019)
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Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions
Tang, Weiting, Beckley, Jacob T., Zhang, Jin, Song, Rui, Xu, Yuchen, Kim, Sukhan, Quirk, Michael C., Robichaud, Albert J., Diaz, Eva Sarai, Myers, Scott J., Doherty, James J., Ackley, Michael A., Traynelis, Stephen F., Yuan, Hongjie
Published in Cellular and molecular life sciences : CMLS (01.02.2023)
Published in Cellular and molecular life sciences : CMLS (01.02.2023)
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