A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction
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Listeria-Based Cancer Vaccines That Segregate Immunogenicity from Toxicity
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Impact of Preexisting Vector-Specific Immunity on Vaccine Potency: Characterization of Listeria monocytogenes-Specific Humoral and Cellular Immunity in Humans and Modeling Studies Using Recombinant Vaccines in Mice
Leong, Meredith L, Hampl, Johannes, Liu, Weiqun, Mathur, Shruti, Bahjat, Keith S, Luckett, William, Dubensky, Thomas W. Jr, Brockstedt, Dirk G
Published in Infection and Immunity (01.09.2009)
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Enhanced virus-specific CD8+ T cell responses by Listeria monocytogenes-infected dendritic cells in the context of Tim-3 blockade
Ma, Cheng J, Ren, Jun P, Li, Guang Y, Wu, Xiao Y, Brockstedt, Dirk G, Lauer, Peter, Moorman, Jonathan P, Yao, Zhi Q
Published in PloS one (2014)
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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
Schietinger, Andrea, Philip, Mary, Krisnawan, Varintra E., Chiu, Edison Y., Delrow, Jeffrey J., Basom, Ryan S., Lauer, Peter, Brockstedt, Dirk G., Knoblaugh, Sue E., Hämmerling, Günter J., Schell, Todd D., Garbi, Natalio, Greenberg, Philip D.
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Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains
Lauer, Peter, Hanson, Bill, Lemmens, Edward E, Liu, Weiqun, Luckett, William S, Leong, Meredith L, Allen, Heather E, Skoble, Justin, Bahjat, Keith S, Freitag, Nancy E, Brockstedt, Dirk G, Dubensky, Thomas W. Jr
Published in Infection and Immunity (01.08.2008)
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Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
Le, Dung T, Wang-Gillam, Andrea, Picozzi, Vincent, Greten, Tim F, Crocenzi, Todd, Springett, Gregory, Morse, Michael, Zeh, Herbert, Cohen, Deirdre, Fine, Robert L, Onners, Beth, Uram, Jennifer N, Laheru, Daniel A, Lutz, Eric R, Solt, Sara, Murphy, Aimee Luck, Skoble, Justin, Lemmens, Ed, Grous, John, Dubensky, Jr, Thomas, Brockstedt, Dirk G, Jaffee, Elizabeth M
Published in Journal of clinical oncology (20.04.2015)
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Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)
Le, Dung T, Picozzi, Vincent J, Ko, Andrew H, Wainberg, Zev A, Kindler, Hedy, Wang-Gillam, Andrea, Oberstein, Paul, Morse, Michael A, Zeh, 3rd, Herbert J, Weekes, Colin, Reid, Tony, Borazanci, Erkut, Crocenzi, Todd, LoConte, Noelle K, Musher, Benjamin, Laheru, Dan, Murphy, Aimee, Whiting, Chan, Nair, Nitya, Enstrom, Amanda, Ferber, Sandy, Brockstedt, Dirk G, Jaffee, Elizabeth M
Published in Clinical cancer research (15.09.2019)
Published in Clinical cancer research (15.09.2019)
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Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma
Hassan, Raffit, Alley, Evan, Kindler, Hedy, Antonia, Scott, Jahan, Thierry, Honarmand, Somayeh, Nair, Nitya, Whiting, Chan C, Enstrom, Amanda, Lemmens, Ed, Tsujikawa, Takahiro, Kumar, Sushil, Choe, Gina, Thomas, Anish, McDougall, Katherine, Murphy, Aimee L, Jaffee, Elizabeth, Coussens, Lisa M, Brockstedt, Dirk G
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Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer
Tsujikawa, Takahiro, Crocenzi, Todd, Durham, Jennifer N, Sugar, Elizabeth A, Wu, Annie A, Onners, Beth, Nauroth, Julie M, Anders, Robert A, Fertig, Elana J, Laheru, Daniel A, Reiss, Kim, Vonderheide, Robert H, Ko, Andrew H, Tempero, Margaret A, Fisher, George A, Considine, Michael, Danilova, Ludmila, Brockstedt, Dirk G, Coussens, Lisa M, Jaffee, Elizabeth M, Le, Dung T
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Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity
Leger, Paul R, Hu, Dennis X, Biannic, Berenger, Bui, Minna, Han, Xinping, Karbarz, Emily, Maung, Jack, Okano, Akinori, Osipov, Maksim, Shibuya, Grant M, Young, Kyle, Higgs, Christopher, Abraham, Betty, Bradford, Delia, Cho, Cynthia, Colas, Christophe, Jacobson, Scott, Ohol, Yamini M, Pookot, Deepa, Rana, Payal, Sanchez, Jerick, Shah, Niket, Sun, Michael, Wong, Steve, Brockstedt, Dirk G, Kassner, Paul D, Schwarz, Jacob B, Wustrow, David J
Published in Journal of medicinal chemistry (28.05.2020)
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A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice
Keenan, Bridget P, Saenger, Yvonne, Kafrouni, Michel I, Leubner, Ashley, Lauer, Peter, Maitra, Anirban, Rucki, Agnieszka A, Gunderson, Andrew J, Coussens, Lisa M, Brockstedt, Dirk G, Dubensky, Thomas W, Hassan, Raffit, Armstrong, Todd D, Jaffee, Elizabeth M
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Published in Gastroenterology (New York, N.Y. 1943) (01.06.2014)
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Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study
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Tumors establish resistance to immunotherapy by regulating T reg recruitment via CCR4
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Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Activation of Immature Hepatic NK Cells As Immunotherapy for Liver Metastatic Disease
Bahjat, Keith S, Prell, Rodney A, Allen, Heather E, Liu, Weiqun, Lemmens, Edward E, Leong, Meredith L, Portnoy, Daniel A, Dubensky, Thomas W., Jr, Brockstedt, Dirk G, Giedlin, Martin A
Published in The Journal of immunology (1950) (01.12.2007)
Published in The Journal of immunology (1950) (01.12.2007)
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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors
Robles, Omar, Jackson, Jeffrey J, Marshall, Lisa, Talay, Oezcan, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Ketcham, John M, McKinnell, Jenny, Meleza, Cesar, Reilly, Maureen K, Riegler, Erin, Shunatona, Hunter P, Wadsworth, Angela, Younai, Ashkaan, Brockstedt, Dirk G, Wustrow, David J, Zibinsky, Mikhail
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Published in Journal of medicinal chemistry (13.08.2020)
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