Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
Shifrut, Eric, Carnevale, Julia, Tobin, Victoria, Roth, Theodore L., Woo, Jonathan M., Bui, Christina T., Li, P. Jonathan, Diolaiti, Morgan E., Ashworth, Alan, Marson, Alexander
Published in Cell (13.12.2018)
Published in Cell (13.12.2018)
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PARP7 Inhibitors and AHR Agonists Act Synergistically Across a Wide-Range of Cancer Models
Chen, Huadong, Gou, Xuxu, Mao, Ying, O'Leary, Patrick C, Diolaiti, Morgan E, Ashworth, Alan
Published in Molecular cancer therapeutics (24.09.2024)
Published in Molecular cancer therapeutics (24.09.2024)
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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Flach, Johanna, Bakker, Sietske T, Mohrin, Mary, Conroy, Pauline C, Pietras, Eric M, Reynaud, Damien, Alvarez, Silvia, Diolaiti, Morgan E, Ugarte, Fernando, Forsberg, E Camilla, Le Beau, Michelle M, Stohr, Bradley A, Méndez, Juan, Morrison, Ciaran G, Passegué, Emmanuelle
Published in Nature (London) (14.08.2014)
Published in Nature (London) (14.08.2014)
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RASA2 ablation in T cells boosts antigen sensitivity and long-term function
Carnevale, Julia, Shifrut, Eric, Kale, Nupura, Nyberg, William A, Blaeschke, Franziska, Chen, Yan Yi, Li, Zhongmei, Bapat, Sagar P, Diolaiti, Morgan E, O'Leary, Patrick, Vedova, Shane, Belk, Julia, Daniel, Bence, Roth, Theodore L, Bachl, Stefanie, Anido, Alejandro Allo, Prinzing, Brooke, Ibañez-Vega, Jorge, Lange, Shannon, Haydar, Dalia, Luetke-Eversloh, Marie, Born-Bony, Maelys, Hegde, Bindu, Kogan, Scott, Feuchtinger, Tobias, Okada, Hideho, Satpathy, Ansuman T, Shannon, Kevin, Gottschalk, Stephen, Eyquem, Justin, Krenciute, Giedre, Ashworth, Alan, Marson, Alexander
Published in Nature (London) (01.09.2022)
Published in Nature (London) (01.09.2022)
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A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo
Taha, Taha Y, Suryawanshi, Rahul K, Chen, Irene P, Correy, Galen J, McCavitt-Malvido, Maria, O'Leary, Patrick C, Jogalekar, Manasi P, Diolaiti, Morgan E, Kimmerly, Gabriella R, Tsou, Chia-Lin, Gascon, Ronnie, Montano, Mauricio, Martinez-Sobrido, Luis, Krogan, Nevan J, Ashworth, Alan, Fraser, James S, Ott, Melanie
Published in PLoS pathogens (01.08.2023)
Published in PLoS pathogens (01.08.2023)
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A protein interaction landscape of breast cancer
Kim, Minkyu, Park, Jisoo, Bouhaddou, Mehdi, Kim, Kyumin, Rojc, Ajda, Modak, Maya, Soucheray, Margaret, McGregor, Michael J, O'Leary, Patrick, Wolf, Denise, Stevenson, Erica, Foo, Tzeh Keong, Mitchell, Dominique, Herrington, Kari A, Muñoz, Denise P, Tutuncuoglu, Beril, Chen, Kuei-Ho, Zheng, Fan, Kreisberg, Jason F, Diolaiti, Morgan E, Gordan, John D, Coppé, Jean-Philippe, Swaney, Danielle L, Xia, Bing, van 't Veer, Laura, Ashworth, Alan, Ideker, Trey, Krogan, Nevan J
Published in Science (American Association for the Advancement of Science) (01.10.2021)
Published in Science (American Association for the Advancement of Science) (01.10.2021)
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De novo design of drug-binding proteins with predictable binding energy and specificity
Lu, Lei, Gou, Xuxu, Tan, Sophia K, Mann, Samuel I, Yang, Hyunjun, Zhong, Xiaofang, Gazgalis, Dimitrios, Valdiviezo, Jesús, Jo, Hyunil, Wu, Yibing, Diolaiti, Morgan E, Ashworth, Alan, Polizzi, Nicholas F, DeGrado, William F
Published in Science (American Association for the Advancement of Science) (05.04.2024)
Published in Science (American Association for the Advancement of Science) (05.04.2024)
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Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
O'Leary, Patrick C, Chen, Huadong, Doruk, Yagmur U, Williamson, Tess, Polacco, Benjamin, McNeal, Andrew S, Shenoy, Tanushree, Kale, Nupura, Carnevale, Julia, Stevenson, Erica, Quigley, David A, Chou, Jonathan, Feng, Felix Y, Swaney, Danielle L, Krogan, Nevan J, Kim, Minkyu, Diolaiti, Morgan E, Ashworth, Alan
Published in Cancer research (Chicago, Ill.) (02.11.2022)
Published in Cancer research (Chicago, Ill.) (02.11.2022)
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Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3‑Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity
Velagapudi, Uday Kiran, Langelier, Marie-France, Delgado-Martin, Cristina, Diolaiti, Morgan E, Bakker, Sietske, Ashworth, Alan, Patel, Bhargav A, Shao, Xuwei, Pascal, John M, Talele, Tanaji T
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM -Deficient Tumors and Potent Synergy With PARP Inhibitors
Thomas, Anish, Fontaine, Shaun D., Diolaiti, Morgan E., Desai, Parth, Kumar, Rajesh, Takahashi, Nobuyuki, Sciuto, Linda, Nichols, Samantha, Ashworth, Alan, Feng, Felix Y., Ashley, Gary W., Nguyen, Minh, Pommier, Yves, Santi, Daniel V.
Published in Molecular cancer therapeutics (03.11.2022)
Published in Molecular cancer therapeutics (03.11.2022)
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In situ visualization of telomere elongation patterns in human cells
Diolaiti, Morgan E, Cimini, Beth A, Kageyama, Robin, Charles, Florie A, Stohr, Bradley A
Published in Nucleic acids research (01.10.2013)
Published in Nucleic acids research (01.10.2013)
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AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid
Chen, Daphne F, Roe, Leah T, Li, Yuping, Borges, Adair L, Zhang, Jenny Y, Babbar, Palak, Maji, Sourobh, Stevens, Maisie G V, Correy, Galen J, Diolaiti, Morgan E, Smith, Dominique H, Ashworth, Alan, Stroud, Robert M, Kelly, Mark J S, Bondy-Denomy, Joseph, Fraser, James S
Published in bioRxiv (26.08.2024)
Published in bioRxiv (26.08.2024)
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Journal Article
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo
Taha, Taha Y, Suryawanshi, Rahul K, Chen, Irene P, Correy, Galen J, O'Leary, Patrick C, Jogalekar, Manasi P, McCavitt-Malvido, Maria, Diolaiti, Morgan E, Kimmerly, Gabriella R, Tsou, Chia-Lin, Martinez-Sobrido, Luis, Krogan, Nevan J, Ashworth, Alan, Fraser, James S, Ott, Melanie
Published in bioRxiv (10.05.2023)
Published in bioRxiv (10.05.2023)
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Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors
Quigley, David, Alumkal, Joshi J, Wyatt, Alexander W, Kothari, Vishal, Foye, Adam, Lloyd, Paul, Aggarwal, Rahul, Kim, Won, Lu, Eric, Schwartzman, Jacob, Beja, Kevin, Annala, Matti, Das, Rajdeep, Diolaiti, Morgan, Pritchard, Colin, Thomas, George, Tomlins, Scott, Knudsen, Karen, Lord, Christopher J, Ryan, Charles, Youngren, Jack, Beer, Tomasz M, Ashworth, Alan, Small, Eric J, Feng, Felix Y
Published in Cancer discovery (01.09.2017)
Published in Cancer discovery (01.09.2017)
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Ablation of Cullin-5 in Primary Human T Cells Improves Tumor Killing and Persistence in BCMA-Targeting CAR-T Cells in a Multiple Myeloma Model
Bachl, Stefanie, Talbot, Alexis, Ching, Carter, Kale, Nupura, Li, Zhongmei, Diolaiti, Morgan, Chen, Amy Peixin, Muldoon, Joseph, Liu, Chang, Martin, Thomas, Eyquem, Justin, Carnevale, Julia
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
Gahbauer, Stefan, Correy, Galen J, Schuller, Marion, Ferla, Matteo P, Doruk, Yagmur Umay, Rachman, Moira, Wu, Taiasean, Diolaiti, Morgan, Wang, Siyi, Neitz, R Jeffrey, Fearon, Daren, Radchenko, Dmytro S, Moroz, Yurii S, Irwin, John J, Renslo, Adam R, Taylor, Jenny C, Gestwicki, Jason E, von Delft, Frank, Ashworth, Alan, Ahel, Ivan, Shoichet, Brian K, Fraser, James S
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2023)
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Journal Article
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2
Gahbauer, Stefan, Correy, Galen J, Schuller, Marion, Ferla, Matteo P, Doruk, Yagmur Umay, Rachman, Moira, Wu, Taiasean, Diolaiti, Morgan, Wang, Siyi, Neitz, R Jeffrey, Fearon, Daren, Radchenko, Dmytro, Moroz, Yurii, Irwin, John J, Renslo, Adam R, Taylor, Jenny C, Gestwicki, Jason E, von Delft, Frank, Ashworth, Alan, Ahel, Ivan, Shoichet, Brian K, Fraser, James S
Published in bioRxiv (28.07.2022)
Published in bioRxiv (28.07.2022)
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