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Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation
Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J
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Published in Journal of medicinal chemistry (30.11.2006)
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The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead
Siu, Tony, Kozina, Ekaterina S., Jung, Joon, Rosenstein, Craig, Mathur, Anjili, Altman, Michael D., Chan, Grace, Xu, Lin, Bachman, Eric, Mo, Jan-Rung, Bouthillette, Melaney, Rush, Thomas, Dinsmore, Christopher J., Marshall, C. Gary, Young, Jonathan R.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
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Parallel Synthesis of Ureas and Carbamates from Amines and CO2 under Mild Conditions
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Published in Organic letters (19.03.2010)
Published in Organic letters (19.03.2010)
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Atrial Antifibrillatory Effects of Structurally Distinct IKur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure
Regan, Christopher P, Kiss, Laszlo, Stump, Gary L, McIntyre, Charles J, Beshore, Douglas C, Liverton, Nigel J, Dinsmore, Christopher J, Lynch, Jr, Joseph J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
Ruiz, E Josue, Pinto-Fernandez, Adan, Turnbull, Andrew P, Lan, Linxiang, Charlton, Thomas M, Scott, Hannah C, Damianou, Andreas, Vere, George, Riising, Eva M, Da Costa, Clive, Krajewski, Wojciech W, Guerin, David, Kearns, Jeffrey D, Ioannidis, Stephanos, Katz, Marie, McKinnon, Crystal, O'Connell, Jonathan, Moncaut, Natalia, Rosewell, Ian, Nye, Emma, Jones, Neil, Heride, Claire, Gersch, Malte, Wu, Min, Dinsmore, Christopher J, Hammonds, Tim R, Kim, Sunkyu, Komander, David, Urbe, Sylvie, Clague, Michael J, Kessler, Benedikt M, Behrens, Axel
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Published in eLife (12.10.2021)
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Discovery of 1-Amino-5H-pyrido[4,3-b]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders
Lim, Jongwon, Taoka, Brandon, Otte, Ryan D, Spencer, Kerrie, Dinsmore, Christopher J, Altman, Michael D, Chan, Grace, Rosenstein, Craig, Sharma, Sujata, Su, Hua-Poo, Szewczak, Alexander A, Xu, Lin, Yin, Hong, Zugay-Murphy, Joan, Marshall, C. Gary, Young, Jonathan R
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase
Dinsmore, Christopher J, Bogusky, Michael J, Culberson, J. Christopher, Bergman, Jeffrey M, Homnick, Carl F, Zartman, C. Blair, Mosser, Scott D, Schaber, Michael D, Robinson, Ronald G, Koblan, Kenneth S, Huber, Hans E, Graham, Samuel L, Hartman, George D, Huff, Joel R, Williams, Theresa M
Published in Journal of the American Chemical Society (07.03.2001)
Published in Journal of the American Chemical Society (07.03.2001)
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The Discovery of 3‑((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)‑4-cyanotetrahydro‑2H‑pyran-3-yl)‑1H‑pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties
Siu, Tony, Brubaker, Jason, Fuller, Peter, Torres, Luis, Zeng, Hongbo, Close, Joshua, Mampreian, Dawn M., Shi, Feng, Liu, Duan, Fradera, Xavier, Johnson, Kevin, Bays, Nathan, Kadic, Elma, He, Fang, Goldenblatt, Peter, Shaffer, Lynsey, Patel, Sangita B., Lesburg, Charles A., Alpert, Carla, Dorosh, Lauren, Deshmukh, Sujal V., Yu, Hongshi, Klappenbach, Joel, Elwood, Fiona, Dinsmore, Christopher J., Fernandez, Rafael, Moy, Lily, Young, Jonathan R.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors
Simov, Vladimir, Deshmukh, Sujal V., Dinsmore, Christopher J., Elwood, Fiona, Fernandez, Rafael B., Garcia, Yudith, Gibeau, Craig, Gunaydin, Hakan, Jung, Joon, Katz, Jason D., Kraybill, Brian, Lapointe, Blair, Patel, Sangita B., Siu, Tony, Su, Hua, Young, Jonathan R.
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
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MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
PAN, Bo-Sheng, CHAN, Grace K. Y, JEWELL, James P, KARIV, Ilona, KATZ, Jason D, KUNII, Kaiko, WEI LU, LUTTERBACH, Bart A, PAWELETZ, Cloud P, XIANLU QU, REILLY, John F, SZEWCZAK, Alexander A, CHENARD, Melissa, QINWEN ZENG, KOHL, Nancy E, DINSMORE, Christopher J, CHI, An, DAVIS, Lenora J, DESHMUKH, Sujal V, GIBBS, Jackson B, GIL, Susana, GAOZHEN HANG, HATCH, Harold
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Discovery of 1‑[3-(1-Methyl‑1H‑pyrazol-4-yl)-5-oxo‑5H‑benzo[4,5]cyclohepta[1,2‑b]pyridin-7-yl]‑N‑(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c‑Met/Ron Dual Kinase Inhibitor with Preferential Affinity for the Activated State of c‑Met
Northrup, Alan B, Katcher, Matthew H, Altman, Michael D, Chenard, Melissa, Daniels, Matthew H, Deshmukh, Sujal V, Falcone, Danielle, Guerin, David J, Hatch, Harold, Li, Chaomin, Lu, Wei, Lutterbach, Bart, Allison, Timothy J, Patel, Sangita B, Reilly, John F, Reutershan, Michael, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Szewczak, Alexander A, Walker, Deborah, Wilson, Kevin, Young, Jonathan R, Pan, Bo-Sheng, Dinsmore, Christopher J
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Approaches to the Synthesis of the Vancomycin Antibiotics. Synthesis of Orienticin C (Bis-dechlorovancomycin) Aglycon
Evans, David A, Barrow, James C, Watson, Paul S, Ratz, Andrew M, Dinsmore, Christopher J, Evrard, Deborah A, DeVries, Keith M, Ellman, Jonathan A, Rychnovsky, Scott D, Lacour, Jérôme
Published in Journal of the American Chemical Society (09.04.1997)
Published in Journal of the American Chemical Society (09.04.1997)
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Discovery of a 5H-Benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer
Katz, Jason D, Jewell, James P, Guerin, David J, Lim, Jongwon, Dinsmore, Christopher J, Deshmukh, Sujal V, Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D, Dahlberg, William K, Davis, Lenora, Falcone, Danielle, Gabarda, Ana E, Hang, Gaozhen, Hatch, Harold, Holmes, Rachael, Kunii, Kaiko, Lumb, Kevin J, Lutterbach, Bart, Mathvink, Robert, Nazef, Naim, Patel, Sangita B, Qu, Xianlu, Reilly, John F, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Spencer, Kerrie B, Szewczak, Alexander A, Walker, Deborah, Wang, Wenxian, Young, Jonathan, Zeng, Qinwen
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Oxidative coupling of arylglycine-containing peptides. A biomimetic approach to the synthesis of the macrocyclic actinoidinic-containing vancomycin subunit
Evans, David A, Dinsmore, Christopher J, Evrard, Deborah A, DeVries, Keith M
Published in Journal of the American Chemical Society (01.07.1993)
Published in Journal of the American Chemical Society (01.07.1993)
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