Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring
Ménard, Delphine, Niculescu-Duvaz, Ion, Dijkstra, Harmen P, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M, Zambon, Alfonso, Nourry, Arnaud, Roman, Esteban, Davies, Lawrence, Manne, Helen A, Friedlos, Frank, Kirk, Ruth, Whittaker, Steven, Gill, Adrian, Taylor, Richard D, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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Journal Article
Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)
Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P, Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M, Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Whittaker, Steven, Kirk, Ruth, Gill, Adrian, Taylor, Richard D, Raynaud, Florence I, Moreno-Farre, Javier, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
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Journal Article
Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group
Suijkerbuijk, Bart M. J. M, Niculescu-Duvaz, Ion, Gaulon, Catherine, Dijkstra, Harmen P, Niculescu-Duvaz, Dan, Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A, Friedlos, Frank, Ogilvie, Lesley M, Hedley, Douglas, Lopes, Filipa, Preece, Natasha P. U, Moreno-Farre, Javier, Raynaud, Florence I, Kirk, Ruth, Whittaker, Steven, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Journal Article
BRAF Inhibitors Based on an Imidazo[4,5]pyridin-2-one Scaffold and a Meta Substituted Middle Ring
Nourry, Arnaud, Zambon, Alfonso, Davies, Lawrence, Niculescu-Duvaz, Ion, Dijkstra, Harmen P, Ménard, Delphine, Gaulon, Catherine, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M, Friedlos, Frank, Manne, Helen A, Kirk, Ruth, Whittaker, Steven, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
Transmission of Binding Information across Lipid Bilayers
Dijkstra, Harmen P., Hutchinson, Jordan J., Hunter, Christopher A., Qin, Haiyuan, Tomas, Salvador, Webb, Simon J., Williams, Nicholas H.
Published in Chemistry : a European journal (01.01.2007)
Published in Chemistry : a European journal (01.01.2007)
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Journal Article
Sulfato-bridged ECE-pincer palladium(II) complexes: structures in the solid-state and in solution, and catalytic properties
Kruithof, Cornelis A, Berger, Alexsandro, Dijkstra, Harmen P, Soulimani, Fouad, Visser, Tom, Lutz, Martin, Spek, Anthony L, Gebbink, Robertus J M Klein, van Koten, Gerard
Published in Dalton transactions : an international journal of inorganic chemistry (01.01.2009)
Published in Dalton transactions : an international journal of inorganic chemistry (01.01.2009)
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Journal Article
Selective and diagnostic labelling of serine hydrolases with reactive phosphonate inhibitors
Dijkstra, Harmen P., Sprong, Hein, Aerts, Bas N. H., Kruithof, Cornelis A., Egmond, Maarten R., Gebbink, Robertus J. M. Klein
Published in Organic & biomolecular chemistry (07.02.2008)
Published in Organic & biomolecular chemistry (07.02.2008)
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Journal Article
A facile synthesis of an oxazolo[5,4]pyrimidin-2-one and a pyrimido[5,4][1,3]oxazin-2-one
Dijkstra, Harmen P., Gaulon, Catherine, Niculescu-Duvaz, Dan, Springer, Caroline J.
Published in Synlett (21.06.2006)
Published in Synlett (21.06.2006)
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Journal Article
Non-Tethered Organometallic Phosphonate Inhibitors for Lipase Inhibition: Positioning of the Metal Center in the Active Site of Cutinase
Kruithof, Cornelis A., Dijkstra, Harmen P., Lutz, Martin, Spek, Anthony L., Egmond, Maarten R., Klein Gebbink, Robertus J. M., van Koten, Gerard
Published in European Journal of Inorganic Chemistry (01.10.2008)
Published in European Journal of Inorganic Chemistry (01.10.2008)
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Journal Article
Corrections to Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)
Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P., Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M., Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Whittaker, Steven, Kirk, Ruth, Gill, Adrian, Taylor, Richard D., Raynaud, Florence I., Moreno-Farre, Javier, Marais, Richard, Springer, Caroline J.
Published in Journal of medicinal chemistry (24.09.2009)
Published in Journal of medicinal chemistry (24.09.2009)
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Journal Article
Imidazo[4,5-b]pyridin-2-on forbindelser og analoger derav som terapeutiske forbindelser
Taylor, Richard David, Dijkstra, Harmen, Marais, Richard Malcolm, Springer, Caroline Joy, Gill, Adrian Liam, Niculescu-Du-Vaz, Dan, Gaulon, Catherine, Mendard, Dephine, Vela, Esteban Roman
Year of Publication 21.08.2017
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Year of Publication 21.08.2017
Patent
IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS
SPRINGER, CAROLINE JOY, GILL, ADRIAN LIAM, ROMAN VELA, ESTEBAN, GAULON, CATHERINE, TAYLOR, RICHARD DAVID, MARAIS, RICHARD MALCOLM, MENARD, DELPHINE, DIJKSTRA, HARMEN, NICULESCU-DUVAZ, DAN
Year of Publication 29.01.2016
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Year of Publication 29.01.2016
Patent
IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS
RICHARD MALCOLM MARAIS, HARMEN DIJKSTRA, CATHERINE GAULON, CAROLINE JOY SPRINGER, RICHARD DAVID TAYLOR, DELPHINE MENARD, DAN NICULESCU-DUVAZ, ADRIAN LIAM GILL, ESTEBAN ROMAN VELA
Year of Publication 02.11.2015
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Year of Publication 02.11.2015
Patent
IMIDAZO[4,5-B]PYRIDIN-2-ON- OG OXAZOLO[4,5-B]PYRIDIN-2-ONFORBINDELSER OG ANALOGER DERAF SOM TERAPEUTISKE FORBINDELSER
SPRINGER, CAROLINE JOY, GILL, ADRIAN LIAM, ROMAN VELA, ESTEBAN, GAULON, CATHERINE, MARAIS, RICHARD MALCOLM, TAYLOR, RICHARD DAVID, MENARD, DELPHINE, DIJKSTRA, HARMEN, NICULESCU-DUVAZ, DAN
Year of Publication 26.10.2015
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Year of Publication 26.10.2015
Patent
IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS
SPRINGER, CAROLINE JOY, GILL, ADRIAN LIAM, ROMAN VELA, ESTEBAN, GAULON, CATHERINE, TAYLOR, RICHARD DAVID, MARAIS, RICHARD MALCOLM, MENARD, DELPHINE, DIJKSTRA, HARMEN, NICULESCU-DUVAZ, DAN
Year of Publication 22.07.2015
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Year of Publication 22.07.2015
Patent
IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS
NICULESCU-DUVAZ, Dan Cancer Research UK Center, Menard, Delphine Cancer Research UK Centre, Gill, Adrian Liam Astex Therapeutics Limited, Taylor, Richard David Astex Therapeutics Limited, Roman Vela, Esteban Cancer Research UK Centre, Marais, Richard Malcolm, Gaulon, Catherine Laboratoire de Synthese Organique, Springer, Caroline Joy Cancer Research UK Center, DIJKSTRA, Harmen
Year of Publication 30.05.2016
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Year of Publication 30.05.2016
Patent