AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer
Jänne, Pasi A, Yang, James Chih-Hsin, Kim, Dong-Wan, Planchard, David, Ohe, Yuichiro, Ramalingam, Suresh S, Ahn, Myung-Ju, Kim, Sang-We, Su, Wu-Chou, Horn, Leora, Haggstrom, Daniel, Felip, Enriqueta, Kim, Joo-Hang, Frewer, Paul, Cantarini, Mireille, Brown, Kathryn H, Dickinson, Paul A, Ghiorghiu, Serban, Ranson, Malcolm
Published in The New England journal of medicine (30.04.2015)
Published in The New England journal of medicine (30.04.2015)
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In vitro models for the prediction of in vivo performance of oral dosage forms
Kostewicz, Edmund S., Abrahamsson, Bertil, Brewster, Marcus, Brouwers, Joachim, Butler, James, Carlert, Sara, Dickinson, Paul A., Dressman, Jennifer, Holm, René, Klein, Sandra, Mann, James, McAllister, Mark, Minekus, Mans, Muenster, Uwe, Müllertz, Anette, Verwei, Miriam, Vertzoni, Maria, Weitschies, Werner, Augustijns, Patrick
Published in European journal of pharmaceutical sciences (16.06.2014)
Published in European journal of pharmaceutical sciences (16.06.2014)
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Journal Article
Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
Dickinson, Paul A, Cantarini, Mireille V, Collier, Jo, Frewer, Paul, Martin, Scott, Pickup, Kathryn, Ballard, Peter
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
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Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies
Planchard, David, Brown, Kathryn H., Kim, Dong-Wan, Kim, Sang-We, Ohe, Yuichiro, Felip, Enriqueta, Leese, Philip, Cantarini, Mireille, Vishwanathan, Karthick, Jänne, Pasi A., Ranson, Malcolm, Dickinson, Paul A.
Published in Cancer chemotherapy and pharmacology (01.04.2016)
Published in Cancer chemotherapy and pharmacology (01.04.2016)
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Journal Article
Determining bioequivalence possibilities of long acting injectables through population PK modelling
Gajjar, Parmesh, Dickinson, Jake, Dickinson, Harri, Ruston, Linette, Mistry, Hitesh B., Patterson, Claire, Dickinson, Paul A.
Published in European journal of pharmaceutical sciences (01.12.2022)
Published in European journal of pharmaceutical sciences (01.12.2022)
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Journal Article
The Effect of Food or Omeprazole on the Pharmacokinetics of Osimertinib in Patients With Non-Small-Cell Lung Cancer and in Healthy Volunteers
Vishwanathan, Karthick, Dickinson, Paul A, Bui, Khanh, Cassier, Philippe A, Greystoke, Alastair, Lisbon, Eleanor, Moreno, Victor, So, Karen, Thomas, Karen, Weilert, Doris, Yap, Timothy A, Plummer, Ruth
Published in Journal of clinical pharmacology (01.04.2018)
Published in Journal of clinical pharmacology (01.04.2018)
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Journal Article
The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib
Vishwanathan, Karthick, Dickinson, Paul A., So, Karen, Thomas, Karen, Chen, Yuh‐Min, De Castro Carpeño, Javier, Dingemans, Anne‐Marie C., Kim, Hye Ryun, Kim, Joo‐Hang, Krebs, Matthew G., Chih‐Hsin Yang, James, Bui, Khanh, Weilert, Doris, Harvey, R. Donald
Published in British journal of clinical pharmacology (01.06.2018)
Published in British journal of clinical pharmacology (01.06.2018)
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Journal Article
STAT2 deficiency and susceptibility to viral illness in humans
Hambleton, Sophie, Goodbourn, Stephen, Young, Dan F., Dickinson, Paul, Mohamad, Siti M. B., Valappil, Manoj, McGovern, Naomi, Cant, Andrew J., Hackett, Scott J., Ghazal, Peter, Morgan, Neil V., Randall, Richard E.
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
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Journal Article
Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to Support Drug Product Quality: A Workshop Summary Report
Mitra, Amitava, Suarez-Sharp, Sandra, Pepin, Xavier J.H., Flanagan, Talia, Zhao, Yang, Kotzagiorgis, Evangelos, Parrott, Neil, Sharan, Satish, Tistaert, Christophe, Heimbach, Tycho, Zolnik, Banu, Sjögren, Erik, Wu, Fang, Anand, Om, Kakar, Shefali, Li, Min, Veerasingham, Shereeni, Kijima, Shinichi, Lima Santos, Gustavo Mendes, Ning, Baoming, Raines, Kimberly, Rullo, Greg, Mandula, Haritha, Delvadia, Poonam, Dressman, Jennifer, Dickinson, Paul A., Babiskin, Andrew
Published in Journal of pharmaceutical sciences (01.02.2021)
Published in Journal of pharmaceutical sciences (01.02.2021)
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Journal Article
High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay
Dölken, Lars, Ruzsics, Zsolt, Rädle, Bernd, Friedel, Caroline C, Zimmer, Ralf, Mages, Jörg, Hoffmann, Reinhard, Dickinson, Paul, Forster, Thorsten, Ghazal, Peter, Koszinowski, Ulrich H
Published in RNA (Cambridge) (01.09.2008)
Published in RNA (Cambridge) (01.09.2008)
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Journal Article
The effects of pharmaceutical excipients on drug disposition
Buggins, Talia R., Dickinson, Paul A., Taylor, Glyn
Published in Advanced drug delivery reviews (22.12.2007)
Published in Advanced drug delivery reviews (22.12.2007)
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Journal Article
Effect of multiple‐dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin
Harvey, R. Donald, Aransay, Noemi Reguart, Isambert, Nicolas, Lee, Jong‐Seok, Arkenau, Tobias, Vansteenkiste, Johan, Dickinson, Paul A., Bui, Khanh, Weilert, Doris, So, Karen, Thomas, Karen, Vishwanathan, Karthick
Published in British journal of clinical pharmacology (01.12.2018)
Published in British journal of clinical pharmacology (01.12.2018)
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Journal Article
Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitation
Larsen, Anne T., Ohlsson, Anja G., Polentarutti, Britta, Barker, Richard A., Phillips, Andrew R., Abu-Rmaileh, Ragheb, Dickinson, Paul A., Abrahamsson, Bertil, Østergaard, Jesper, Müllertz, Anette
Published in European journal of pharmaceutical sciences (23.01.2013)
Published in European journal of pharmaceutical sciences (23.01.2013)
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Journal Article
Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A, Watterson, Steven, Shui, Guanghou, Lacaze, Paul, Khondoker, Mizanur, Dickinson, Paul, Sing, Garwin, Rodríguez-Martín, Sara, Phelan, Peter, Forster, Thorsten, Strobl, Birgit, Müller, Matthias, Riemersma, Rudolph, Osborne, Timothy, Wenk, Markus R, Angulo, Ana, Ghazal, Peter
Published in PLoS biology (01.03.2011)
Published in PLoS biology (01.03.2011)
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Journal Article
Correction to: Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products
Selen, Arzu, Müllertz, Anette, Kesisoglou, Filippos, Ho, Rodney J. Y., Cook, Jack A., Dickinson, Paul A., Flanagan, Talia
Published in The AAPS journal (03.12.2020)
Published in The AAPS journal (03.12.2020)
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Journal Article
Self-Adaptive Air-path Health Management for a Heavy Duty-Diesel Engine
Poloni, Tomas, Dickinson, Paul, Zhang, Jianrui, Zhou, Peng
Published in International journal of prognostics and health management (13.02.2023)
Published in International journal of prognostics and health management (13.02.2023)
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Journal Article
Exploring a model-based analysis of patient derived xenograft studies in oncology drug development
Dickinson, Jake, de Matas, Marcel, Dickinson, Paul A, Mistry, Hitesh B
Published in PeerJ (San Francisco, CA) (27.01.2021)
Published in PeerJ (San Francisco, CA) (27.01.2021)
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Journal Article
Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products
Selen, Arzu, Müllertz, Anette, Kesisoglou, Filippos, Ho, Rodney J. Y., Cook, Jack A., Dickinson, Paul A., Flanagan, Talia
Published in The AAPS journal (27.07.2020)
Published in The AAPS journal (27.07.2020)
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Journal Article
An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
Dickinson, Paul A., Abu Rmaileh, Ragheb, Ashworth, Lee, Barker, Richard A., Burke, Wendy M., Patterson, Claire M., Stainforth, Nick, Yasin, Mohammed
Published in The AAPS journal (01.06.2012)
Published in The AAPS journal (01.06.2012)
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Journal Article
Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade
Fliss, Patricia M, Jowers, Tali Pechenick, Brinkmann, Melanie M, Holstermann, Barbara, Mack, Claudia, Dickinson, Paul, Hohenberg, Heinrich, Ghazal, Peter, Brune, Wolfram
Published in PLoS pathogens (01.02.2012)
Published in PLoS pathogens (01.02.2012)
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