Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164
Le, Dung T, Kim, Tae Won, Van Cutsem, Eric, Geva, Ravit, Jäger, Dirk, Hara, Hiroki, Burge, Matthew, O'Neil, Bert, Kavan, Petr, Yoshino, Takayuki, Guimbaud, Rosine, Taniguchi, Hiroya, Elez, Elena, Al-Batran, Salah-Eddin, Boland, Patrick M, Crocenzi, Todd, Atreya, Chloe E, Cui, Yi, Dai, Tong, Marinello, Patricia, Diaz, Jr, Luis A, André, Thierry
Published in Journal of clinical oncology (01.01.2020)
Published in Journal of clinical oncology (01.01.2020)
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Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
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Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
Kim, KiBem, Skora, Andrew D., Li, Zhaobo, Liu, Qiang, Tam, Ada J., Blosser, Richard L., Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin
Published in Proceedings of the National Academy of Sciences - PNAS (12.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (12.08.2014)
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The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors
Rousseau, Benoit, Foote, Michael B, Maron, Steven B, Diplas, Bill H, Lu, Steve, Argilés, Guillem, Cercek, Andrea, Diaz, Luis A
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Published in The New England journal of medicine (25.03.2021)
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Cancer Genome Landscapes
Vogelstein, Bert, Papadopoulos, Nickolas, Velculescu, Victor E., Zhou, Shibin, Diaz, Luis A., Kinzler, Kenneth W.
Published in Science (American Association for the Advancement of Science) (29.03.2013)
Published in Science (American Association for the Advancement of Science) (29.03.2013)
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Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
Vogelstein, Bert, Papadopoulos, Nickolas, He, Yiping, Wu, Jian, Dressman, Devin C, Iacobuzio-Donahue, Christine, Markowitz, Sanford D, Velculescu, Victor E, Diaz Jr, Luis A, Kinzler, Kenneth W
Published in Nature (London) (25.03.2010)
Published in Nature (London) (25.03.2010)
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Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade
Lee, Valerie, Murphy, Adrian, Le, Dung T., Diaz, Luis A.
Published in The oncologist (Dayton, Ohio) (01.10.2016)
Published in The oncologist (Dayton, Ohio) (01.10.2016)
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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
Diaz Jr, Luis A., Williams, Richard T., Wu, Jian, Kinde, Isaac, Hecht, J. Randolph, Berlin, Jordan, Allen, Benjamin, Bozic, Ivana, Reiter, Johannes G., Nowak, Martin A., Kinzler, Kenneth W., Oliner, Kelly S., Vogelstein, Bert
Published in Nature (London) (28.06.2012)
Published in Nature (London) (28.06.2012)
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Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? : A Systematic Review
Mitchell, Aaron P, Trivedi, Niti U, Gennarelli, Renee L, Chimonas, Susan, Tabatabai, Sara M, Goldberg, Johanna, Diaz, Jr, Luis A, Korenstein, Deborah
Published in Annals of internal medicine (01.03.2021)
Published in Annals of internal medicine (01.03.2021)
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Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study
Diaz, Luis A, Shiu, Kai-Keen, Kim, Tae-Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis, Smith, Denis, Garcia-Carbonero, Rocio, Benavides, Manuel, Gibbs, Peter, de la Fourchardiere, Christelle, Rivera, Fernando, Elez, Elena, Le, Dung T, Yoshino, Takayuki, Zhong, Wen Yan, Fogelman, David, Marinello, Patricia, Andre, Thierry
Published in The lancet oncology (01.05.2022)
Published in The lancet oncology (01.05.2022)
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Circulating mutant DNA to assess tumor dynamics
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Published in Nature medicine (01.09.2008)
Published in Nature medicine (01.09.2008)
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Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
Wu, Jian, Jiao, Yuchen, Dal Molin, Marco, Maitra, Anirban, de Wilde, Roeland F, Wood, Laura D, Eshleman, James R, Goggins, Michael G, Wolfgang, Christopher L, Canto, Marcia I, Schulick, Richard D, Edil, Barish H, Choti, Michael A, Adsay, Volkan, Klimstra, David S, Offerhaus, G. Johan A, Klein, Alison P, Kopelovich, Levy, Carter, Hannah, Karchin, Rachel, Allen, Peter J, Schmidt, C. Max, Naito, Yoshiki, Diaz, Luis A. Jr, Kinzler, Kenneth W, Papadopoulos, Nickolas, Hruban, Ralph H, Vogelstein, Bert
Published in Proceedings of the National Academy of Sciences - PNAS (27.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (27.12.2011)
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The genomic landscape of response to EGFR blockade in colorectal cancer
Bertotti, Andrea, Papp, Eniko, Jones, Siân, Adleff, Vilmos, Anagnostou, Valsamo, Lupo, Barbara, Sausen, Mark, Phallen, Jillian, Hruban, Carolyn A., Tokheim, Collin, Niknafs, Noushin, Nesselbush, Monica, Lytle, Karli, Sassi, Francesco, Cottino, Francesca, Migliardi, Giorgia, Zanella, Eugenia R., Ribero, Dario, Russolillo, Nadia, Mellano, Alfredo, Muratore, Andrea, Paraluppi, Gianluca, Salizzoni, Mauro, Marsoni, Silvia, Kragh, Michael, Lantto, Johan, Cassingena, Andrea, Li, Qing Kay, Karchin, Rachel, Scharpf, Robert, Sartore-Bianchi, Andrea, Siena, Salvatore, Diaz, Luis A., Trusolino, Livio, Velculescu, Victor E.
Published in Nature (London) (08.10.2015)
Published in Nature (London) (08.10.2015)
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DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
Jiao, Yuchen, Shi, Chanjuan, Edil, Barish H, de Wilde, Roeland F, Klimstra, David S, Maitra, Anirban, Schulick, Richard D, Tang, Laura H, Wolfgang, Christopher L, Choti, Michael A, Velculescu, Victor E, Diaz, Luis A. Jr, Vogelstein, Bert, Kinzler, Kenneth W, Hruban, Ralph H, Papadopoulos, Nickolas
Published in Science (American Association for the Advancement of Science) (04.03.2011)
Published in Science (American Association for the Advancement of Science) (04.03.2011)
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Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
Yun, Jihye, Rago, Carlo, Cheong, Ian, Pagliarini, Ray, Angenendt, Philipp, Rajagopalan, Harith, Schmidt, Kerstin, Willson, James K.V, Markowitz, Sandy, Zhou, Shibin, Diaz, Luis A. Jr, Velculescu, Victor E, Lengauer, Christoph, Kinzler, Kenneth W, Vogelstein, Bert, Papadopoulos, Nickolas
Published in Science (American Association for the Advancement of Science) (18.09.2009)
Published in Science (American Association for the Advancement of Science) (18.09.2009)
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Phallen, Jillian, Sausen, Mark, Adleff, Vilmos, Leal, Alessandro, Hruban, Carolyn, White, James, Anagnostou, Valsamo, Fiksel, Jacob, Cristiano, Stephen, Papp, Eniko, Speir, Savannah, Reinert, Thomas, Orntoft, Mai-Britt Worm, Woodward, Brian D, Murphy, Derek, Parpart-Li, Sonya, Riley, David, Nesselbush, Monica, Sengamalay, Naomi, Georgiadis, Andrew, Li, Qing Kay, Madsen, Mogens Rørbæk, Mortensen, Frank Viborg, Huiskens, Joost, Punt, Cornelis, van Grieken, Nicole, Fijneman, Remond, Meijer, Gerrit, Husain, Hatim, Scharpf, Robert B, Diaz, Jr, Luis A, Jones, Siân, Angiuoli, Sam, Ørntoft, Torben, Nielsen, Hans Jørgen, Andersen, Claus Lindbjerg, Velculescu, Victor E
Published in Science translational medicine (16.08.2017)
Published in Science translational medicine (16.08.2017)
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Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177): an open-label, randomised, phase 3 trial
Andre, Thierry, Amonkar, Mayur, Norquist, Josephine M, Shiu, Kai-Keen, Kim, Tae Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis J A, Smith, Denis, Garcia-Carbonero, Rocio, Sevilla, Isabel, De La Fouchardiere, Christelle, Rivera, Fernando, Elez, Elena, Diaz, Luis A, Yoshino, Takayuki, Van Cutsem, Eric, Yang, Ping, Farooqui, Mohammed, Le, Dung T
Published in The lancet oncology (01.05.2021)
Published in The lancet oncology (01.05.2021)
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