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Published in Rapid communications in mass spectrometry (30.05.1999)
Published in Rapid communications in mass spectrometry (30.05.1999)
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Published in Journal of medicinal chemistry (05.12.2002)
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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification
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Published in Bioorganic & medicinal chemistry letters (01.12.2002)
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
Hastings, Nicholas B, Wang, Xiaohai, Song, Lixin, Butts, Brent D, Grotz, Diane, Hargreaves, Richard, Fred Hess, J, Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X, Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J, Ouyang, Xuesong, Rosahl, Thomas W, Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J, Wang, Ganfeng, Duffy, Joseph L, Parker, Eric M, Zhang, Lili
Published in Molecular neurodegeneration (18.05.2017)
Published in Molecular neurodegeneration (18.05.2017)
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Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution
BOYLE, Craig D, CHACKALAMANNIL, Samuel, YUGUANG WANG, GUOWEI ZHOU, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, COHEN-WILLIAMS, Mary, COFFIN, Vicki L, COX, Kathleen A, GROTZ, Diane E, DUFFY, Ruth A, CLADER, John W, RUPERTO, Vilma, LACHOWICZ, Jean E, GREENLEE, William J, JOSIEN, Hubert B, KAMINSKI, James J, KOZLOWSKI, Joseph A, MCCOMBIE, Stuart W, NAZARENO, Dennis V, TAGAT, Jayaram R
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Structure-Based Design of an Iminoheterocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates
Mandal, Mihirbaran, Wu, Yusheng, Misiaszek, Jeffrey, Li, Guoqing, Buevich, Alexei, Caldwell, John P, Liu, Xiaoxiang, Mazzola, Robert D, Orth, Peter, Strickland, Corey, Voigt, Johannes, Wang, Hongwu, Zhu, Zhaoning, Chen, Xia, Grzelak, Michael, Hyde, Lynn A, Kuvelkar, Reshma, Leach, Prescott T, Terracina, Giuseppe, Zhang, Lili, Zhang, Qi, Michener, Maria S, Smith, Brad, Cox, Kathleen, Grotz, Diane, Favreau, Leonard, Mitra, Kaushik, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Kennedy, Matthew E, Parker, Eric M, Cumming, Jared N, Stamford, Andrew W
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety
Mandal, Mihirbaran, Mitra, Kaushik, Grotz, Diane, Lin, Xinjie, Palamanda, Jairam, Kumari, Pramila, Buevich, Alexei, Caldwell, John P, Chen, Xia, Cox, Kathleen, Favreau, Leonard, Hyde, Lynn, Kennedy, Matthew E, Kuvelkar, Reshma, Liu, Xiaoxiang, Mazzola, Robert D, Parker, Eric, Rindgen, Diane, Sherer, Edward, Wang, Hongwu, Zhu, Zhaoning, Stamford, Andrew W, Cumming, Jared N
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist
DeMong, Duane, Dai, Xing, Hwa, Joyce, Miller, Michael, Lin, Sue-Ing, Kang, Ling, Stamford, Andrew, Greenlee, William, Yu, Wensheng, Wong, Michael, Lavey, Brian, Kozlowski, Joseph, Zhou, Guowei, Yang, De-Yi, Patel, Bhuneshwari, Soriano, Aileen, Zhai, Ying, Sondey, Christopher, Zhang, Hongtao, Lachowicz, Jean, Grotz, Diane, Cox, Kathleen, Morrison, Richard, Andreani, Teresa, Cao, Yang, Liang, Mark, Meng, Tao, McNamara, Paul, Wong, Jesse, Bradley, Prudence, Feng, Kung-I, Belani, Jitendra, Chen, Ping, Dai, Peng, Gauuan, Jolicia, Lin, Peishan, Zhao, He
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios
YAU YI LAU, KRISHNA, Gopal, YUMIBE, Nathan P, GROTZ, Diane E, SAPIDOU, Elpida, NORTON, Laura, INHOU CHU, CHEN, Cliff, SOARES, A. D, LIN, Chin-Chung
Published in Pharmaceutical research (01.11.2002)
Published in Pharmaceutical research (01.11.2002)
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Improving the oral efficacy of CNS drug candidates: Discovery of highly orally efficacious piperidinyl piperidine M-2 muscarinic receptor antagonists
Wang, YG, Chackalamannil, S, Hu, ZY, Greenlee, WJ, Clader, J, Boyle, CD, Kaminski, JJ, Billard, W, Binch, H, Crosby, G, Ruperto, Duffy, RA, Cohen-Williams, M, Coffin, VL, Cox, KA, Grotz, DE, Lachowicz, JE
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M 2 muscarinic receptor antagonists via benzamide modification
Boyle, Craig D., Vice, Susan F., Campion, Jennifer, Chackalamannil, Samuel, Lankin, Claire M., McCombie, Stuart W., Billard, William, Binch, III, Herbert, Crosby, Gordon, Williams, Mary-Cohen, Coffin, Vicki L., Cox, Kathleen A., Grotz, Diane E., Duffy, Ruth A., Ruperto, Vilma, Lachowicz, Jean E.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification
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Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution
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Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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SHAH, UNMESH, TONG, WEI, GROTZ, DIANE, TING, PAULINE, C, KUANG, RONGZE, ZHOU, GANG, COX, KATHLEEN, CHOWDBURY, SWAPAN
Year of Publication 04.10.2012
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Year of Publication 04.10.2012
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CCR5 antagonists useful for treating HIV
RAMANATHAN, RAGULAN, CHOWDHURY, SWAPAN K, RINDGEN, DIANE, MILLER, MICHAEL W, GROTZ, DIANE, TENDOLKAR, AMOL, ALTON, KEVIN B
Year of Publication 24.06.2009
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Year of Publication 24.06.2009
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CCR5 ANTAGONISTS USEFUL FOR TREATING HIV
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Year of Publication 03.12.2008
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Year of Publication 03.12.2008
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CCR5 ANTAGONISTS USEFUL FOR TREATING HIV
CHOWDHURY SWAPAN K, MILLER MICHAEL W, TENDOLKAR AMOL, ALTON KEVIN B, GROTZ DIANE, RAMANATHAN RAGU IAN, RINDGEN DIANE
Year of Publication 10.11.2008
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Year of Publication 10.11.2008
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CCR5 ANTAGONISTS USEFUL FOR TREATING HIV
ALTON, KEVIN, B, CHOWDHURY, SWAPAN, K, RAMANATHAN, RAGULAN, RINDGEN, DIANE, GROTZ, DIANE, MILLER, MICHAEL, W, TENDOLKAR, AMOL
Year of Publication 07.09.2007
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Year of Publication 07.09.2007
Patent
CCR5 antagonists useful for treating HIV
SWAPAN K. CHOWDHURY, AMOL TENDOLKAR, RAGULAN RAMANATHAN, DIANE GROTZ, KEVIN B. ALTON, DIANE RINDGEN, MICHAEL W. MILLER
Year of Publication 07.09.2007
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Year of Publication 07.09.2007
Patent
CCR5 ANTAGONISTS USEFUL FOR TREATING HIV
CHOWDHURY, SWAPAN K, RAMANATHAN, RAGULAN, RINDGEN, DIANE, MILLER, MICHAEL W, GROTZ, DIANE, TENDOLKAR, AMOL, ALTON, KEVIN B
Year of Publication 07.09.2007
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Year of Publication 07.09.2007
Patent