Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
Chen, Rui, Mias, George I., Li-Pook-Than, Jennifer, Jiang, Lihua, Lam, Hugo Y.K., Chen, Rong, Miriami, Elana, Karczewski, Konrad J., Hariharan, Manoj, Dewey, Frederick E., Cheng, Yong, Clark, Michael J., Im, Hogune, Habegger, Lukas, Balasubramanian, Suganthi, O'Huallachain, Maeve, Dudley, Joel T., Hillenmeyer, Sara, Haraksingh, Rajini, Sharon, Donald, Euskirchen, Ghia, Lacroute, Phil, Bettinger, Keith, Boyle, Alan P., Kasowski, Maya, Grubert, Fabian, Seki, Scott, Garcia, Marco, Whirl-Carrillo, Michelle, Gallardo, Mercedes, Blasco, Maria A., Greenberg, Peter L., Snyder, Phyllis, Klein, Teri E., Altman, Russ B., Butte, Atul J., Ashley, Euan A., Gerstein, Mark, Nadeau, Kari C., Tang, Hua, Snyder, Michael
Published in Cell (16.03.2012)
Published in Cell (16.03.2012)
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Journal Article
Clinical Interpretation and Implications of Whole-Genome Sequencing
Dewey, Frederick E, Grove, Megan E, Pan, Cuiping, Goldstein, Benjamin A, Bernstein, Jonathan A, Chaib, Hassan, Merker, Jason D, Goldfeder, Rachel L, Enns, Gregory M, David, Sean P, Pakdaman, Neda, Ormond, Kelly E, Caleshu, Colleen, Kingham, Kerry, Klein, Teri E, Whirl-Carrillo, Michelle, Sakamoto, Kenneth, Wheeler, Matthew T, Butte, Atul J, Ford, James M, Boxer, Linda, Ioannidis, John P. A, Yeung, Alan C, Altman, Russ B, Assimes, Themistocles L, Snyder, Michael, Ashley, Euan A, Quertermous, Thomas
Published in JAMA : the journal of the American Medical Association (12.03.2014)
Published in JAMA : the journal of the American Medical Association (12.03.2014)
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Journal Article
Performance comparison of whole-genome sequencing platforms
Lam, Hugo Y K, Clark, Michael J, Chen, Rui, Chen, Rong, Natsoulis, Georges, O'Huallachain, Maeve, Dewey, Frederick E, Habegger, Lukas, Ashley, Euan A, Gerstein, Mark B, Butte, Atul J, Ji, Hanlee P, Snyder, Michael
Published in Nature biotechnology (01.01.2012)
Published in Nature biotechnology (01.01.2012)
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Journal Article
Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease
Zhu, Na, Welch, Carrie L, Wang, Jiayao, Allen, Philip M, Gonzaga-Jauregui, Claudia, Ma, Lijiang, King, Alejandra K, Krishnan, Usha, Rosenzweig, Erika B, Ivy, D Dunbar, Austin, Eric D, Hamid, Rizwan, Pauciulo, Michael W, Lutz, Katie A, Nichols, William C, Reid, Jeffrey G, Overton, John D, Baras, Aris, Dewey, Frederick E, Shen, Yufeng, Chung, Wendy K
Published in Genome medicine (20.07.2018)
Published in Genome medicine (20.07.2018)
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Journal Article
Genomic diagnostics within a medically underserved population: efficacy and implications
Strauss, Kevin A., Gonzaga-Jauregui, Claudia, Brigatti, Karlla W., Williams, Katie B., King, Alejandra K., Van Hout, Cristopher, Robinson, Donna L., Young, Millie, Praveen, Kavita, Heaps, Adam D., Kuebler, Mindy, Baras, Aris, Reid, Jeffrey G., Overton, John D., Dewey, Frederick E., Jinks, Robert N., Finnegan, Ian, Mellis, Scott J., Shuldiner, Alan R., Puffenberger, Erik G.
Published in Genetics in medicine (01.01.2018)
Published in Genetics in medicine (01.01.2018)
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Journal Article
Electrocardiographic predictors of atrial fibrillation
Perez, Marco V., MD, Dewey, Frederick E., MD, Marcus, Rachel, MD, Ashley, Euan A., MRCP, DPhil, MD, Al-Ahmad, Amin A., MD, Wang, Paul J., MD, Froelicher, Victor F., MD, FACC
Published in The American heart journal (01.10.2009)
Published in The American heart journal (01.10.2009)
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Journal Article
Molecular diagnosis of long QT syndrome at 10 days of life by rapid whole genome sequencing
Priest, James R., MD, Ceresnak, Scott R., MD, Dewey, Frederick E., MD, Malloy-Walton, Lindsey E., DO, Dunn, Kyla, MS, Grove, Megan E., MS, Perez, Marco V., MD, Maeda, Katsuhide, MD, PhD, Dubin, Anne M., MD, FHRS, Ashley, Euan A., MRCP, DPhil
Published in Heart rhythm (01.10.2014)
Published in Heart rhythm (01.10.2014)
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Journal Article
Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure
Perez, Marco V., MD, Pavlovic, Aleksandra, BS, Shang, Ching, PhD, Wheeler, Matthew T., MD, PhD, Miller, Clint L., PhD, Liu, Jing, MD, Dewey, Frederick E., MD, PhD, Pan, Stephen, MD, MS, Thanaporn, Porama K., MD, Absher, Devin, PhD, Brandimarto, Jeffrey, PhD, Salisbury, Heidi, RN, MSN, CNS, Chan, Khin, MD, Mukherjee, Rupak, PhD, Konadhode, Roda P., PhD, Myers, Richard M., PhD, Sedehi, Daniel, MD, Scammell, Thomas E., MD, Quertermous, Thomas, MD, Cappola, Thomas, MD, ScM, Ashley, Euan A., MRCP, DPhil
Published in Journal of the American College of Cardiology (08.12.2015)
Published in Journal of the American College of Cardiology (08.12.2015)
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Journal Article
Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure
Dewey, Frederick E, Perez, Marco V, Wheeler, Matthew T, Watt, Clifton, Spin, Joshua, Langfelder, Peter, Horvath, Steve, Hannenhalli, Sridhar, Cappola, Thomas P, Ashley, Euan A
Published in Circulation. Cardiovascular genetics (01.02.2011)
Published in Circulation. Cardiovascular genetics (01.02.2011)
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Journal Article
Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data
Dewey, Frederick E, Grove, Megan E, Priest, James R, Waggott, Daryl, Batra, Prag, Miller, Clint L, Wheeler, Matthew, Zia, Amin, Pan, Cuiping, Karzcewski, Konrad J, Miyake, Christina, Whirl-Carrillo, Michelle, Klein, Teri E, Datta, Somalee, Altman, Russ B, Snyder, Michael, Quertermous, Thomas, Ashley, Euan A
Published in PLoS genetics (01.10.2015)
Published in PLoS genetics (01.10.2015)
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Journal Article
Prognostic value of heart rate increase at onset of exercise testing
LEEPER, Nicholas J, DEWEY, Frederick E, ASHLEY, Euan A, SANDRI, Marcus, SWEE YAW TAN, HADLEY, David, MYERS, Jonathan, FROELICHER, Victor
Published in Circulation (New York, N.Y.) (30.01.2007)
Published in Circulation (New York, N.Y.) (30.01.2007)
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Journal Article
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
Klarin, Derek, Damrauer, Scott M., Cho, Kelly, Sun, Yan V., Teslovich, Tanya M., Honerlaw, Jacqueline, Gagnon, David R., DuVall, Scott L., Li, Jin, Peloso, Gina M., Chaffin, Mark, Small, Aeron M., Huang, Jie, Tang, Hua, Lynch, Julie A., Ho, Yuk-Lam, Liu, Dajiang J., Emdin, Connor A., Li, Alexander H., Huffman, Jennifer E., Lee, Jennifer S., Natarajan, Pradeep, Chowdhury, Rajiv, Saleheen, Danish, Vujkovic, Marijana, Baras, Aris, Pyarajan, Saiju, Di Angelantonio, Emanuele, Neale, Benjamin M., Naheed, Aliya, Khera, Amit V., Danesh, John, Chang, Kyong-Mi, Abecasis, Gonçalo, Willer, Cristen, Dewey, Frederick E., Carey, David J., Concato, John, Gaziano, J. Michael, O’Donnell, Christopher J., Tsao, Philip S., Kathiresan, Sekar, Rader, Daniel J., Wilson, Peter W. F., Assimes, Themistocles L.
Published in Nature genetics (01.11.2018)
Published in Nature genetics (01.11.2018)
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Journal Article
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Dewey, Frederick E, Gusarova, Viktoria, Dunbar, Richard L, O’Dushlaine, Colm, Schurmann, Claudia, Gottesman, Omri, McCarthy, Shane, Van Hout, Cristopher V, Bruse, Shannon, Dansky, Hayes M, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Habegger, Lukas, Lopez, Alex, Penn, John, Zhao, An, Shao, Weiping, Stahl, Neil, Murphy, Andrew J, Hamon, Sara, Bouzelmat, Aurelie, Zhang, Rick, Shumel, Brad, Pordy, Robert, Gipe, Daniel, Herman, Gary A, Sheu, Wayne H.H, Lee, I-Te, Liang, Kae-Woei, Guo, Xiuqing, Rotter, Jerome I, Chen, Yii-Der I, Kraus, William E, Shah, Svati H, Damrauer, Scott, Small, Aeron, Rader, Daniel J, Wulff, Anders Berg, Nordestgaard, Børge G, Tybjærg-Hansen, Anne, van den Hoek, Anita M, Princen, Hans M.G, Ledbetter, David H, Carey, David J, Overton, John D, Reid, Jeffrey G, Sasiela, William J, Banerjee, Poulabi, Shuldiner, Alan R, Borecki, Ingrid B, Teslovich, Tanya M, Yancopoulos, George D, Mellis, Scott J, Gromada, Jesper, Baras, Aris
Published in The New England journal of medicine (20.07.2017)
Published in The New England journal of medicine (20.07.2017)
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Journal Article
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Dewey, Frederick E, Gusarova, Viktoria, O’Dushlaine, Colm, Gottesman, Omri, Trejos, Jesus, Hunt, Charleen, Van Hout, Cristopher V, Habegger, Lukas, Buckler, David, Lai, Ka-Man V, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Ledbetter, David H, Penn, John, Lopez, Alexander, Borecki, Ingrid B, Overton, John D, Reid, Jeffrey G, Carey, David J, Murphy, Andrew J, Yancopoulos, George D, Baras, Aris, Gromada, Jesper, Shuldiner, Alan R
Published in The New England journal of medicine (24.03.2016)
Published in The New England journal of medicine (24.03.2016)
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Journal Article
Genetic identification of familial hypercholesterolemia within a single U.S. health care system
Abul-Husn, Noura S., Manickam, Kandamurugu, Jones, Laney K., Wright, Eric A., Hartzel, Dustin N., Gonzaga-Jauregui, Claudia, O'Dushlaine, Colm, Leader, Joseph B., Kirchner, H. Lester, Lindbuchler, D'Andra M., Barr, Marci L., Giovanni, Monica A., Ritchie, Marylyn D., Overton, John D., Reid, Jeffrey G., Metpally, Raghu P. R., Wardeh, Amr H., Borecki, Ingrid B., Yancopoulos, George D., Baras, Aris, Shuldiner, Alan R., Gottesman, Omri, Ledbetter, David H., Carey, David J., Dewey, Frederick E., Murray, Michael F.
Published in Science (American Association for the Advancement of Science) (23.12.2016)
Published in Science (American Association for the Advancement of Science) (23.12.2016)
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Journal Article
Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation
Choi, Seung Hoan, Weng, Lu-Chen, Roselli, Carolina, Lin, Honghuang, Haggerty, Christopher M, Shoemaker, M. Benjamin, Barnard, John, Arking, Dan E, Chasman, Daniel I, Albert, Christine M, Chaffin, Mark, Tucker, Nathan R, Smith, Jonathan D, Gupta, Namrata, Gabriel, Stacey, Margolin, Lauren, Shea, Marisa A, Shaffer, Christian M, Yoneda, Zachary T, Boerwinkle, Eric, Smith, Nicholas L, Silverman, Edwin K, Redline, Susan, Vasan, Ramachandran S, Burchard, Esteban G, Gogarten, Stephanie M, Laurie, Cecelia, Blackwell, Thomas W, Abecasis, Gonçalo, Carey, David J, Fornwalt, Brandon K, Smelser, Diane T, Baras, Aris, Dewey, Frederick E, Jaquish, Cashell E, Papanicolaou, George J, Sotoodehnia, Nona, Van Wagoner, David R, Psaty, Bruce M, Kathiresan, Sekar, Darbar, Dawood, Alonso, Alvaro, Heckbert, Susan R, Chung, Mina K, Roden, Dan M, Benjamin, Emelia J, Murray, Michael F, Lunetta, Kathryn L, Lubitz, Steven A, Ellinor, Patrick T
Published in JAMA : the journal of the American Medical Association (11.12.2018)
Published in JAMA : the journal of the American Medical Association (11.12.2018)
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Journal Article
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease
Khera, Amit V, Won, Hong-Hee, Peloso, Gina M, O’Dushlaine, Colm, Liu, Dajiang, Stitziel, Nathan O, Natarajan, Pradeep, Nomura, Akihiro, Emdin, Connor A, Gupta, Namrata, Borecki, Ingrid B, Asselta, Rosanna, Duga, Stefano, Merlini, Piera Angelica, Correa, Adolfo, Kessler, Thorsten, Wilson, James G, Bown, Matthew J, Hall, Alistair S, Braund, Peter S, Carey, David J, Murray, Michael F, Kirchner, H. Lester, Leader, Joseph B, Lavage, Daniel R, Manus, J. Neil, Hartzel, Dustin N, Samani, Nilesh J, Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Lander, Eric S, Rader, Daniel J, Danesh, John, Ardissino, Diego, Gabriel, Stacey, Willer, Cristen, Abecasis, Gonçalo R, Saleheen, Danish, Dewey, Frederick E, Kathiresan, Sekar
Published in JAMA : the journal of the American Medical Association (07.03.2017)
Published in JAMA : the journal of the American Medical Association (07.03.2017)
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Journal Article
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Gusarova, Viktoria, O’Dushlaine, Colm, Teslovich, Tanya M., Benotti, Peter N., Mirshahi, Tooraj, Gottesman, Omri, Van Hout, Cristopher V., Murray, Michael F., Mahajan, Anubha, Nielsen, Jonas B., Fritsche, Lars, Wulff, Anders Berg, Gudbjartsson, Daniel F., Sjögren, Marketa, Emdin, Connor A., Scott, Robert A., Lee, Wen-Jane, Small, Aeron, Kwee, Lydia C., Dwivedi, Om Prakash, Prasad, Rashmi B., Bruse, Shannon, Lopez, Alexander E., Penn, John, Marcketta, Anthony, Leader, Joseph B., Still, Christopher D., Kirchner, H. Lester, Mirshahi, Uyenlinh L., Wardeh, Amr H., Hartle, Cassandra M., Habegger, Lukas, Fetterolf, Samantha N., Tusie-Luna, Teresa, Morris, Andrew P., Holm, Hilma, Steinthorsdottir, Valgerdur, Sulem, Patrick, Thorsteinsdottir, Unnur, Rotter, Jerome I., Chuang, Lee-Ming, Damrauer, Scott, Birtwell, David, Brummett, Chad M., Khera, Amit V., Natarajan, Pradeep, Orho-Melander, Marju, Flannick, Jason, Lotta, Luca A., Willer, Cristen J., Holmen, Oddgeir L., Ritchie, Marylyn D., Ledbetter, David H., Murphy, Andrew J., Borecki, Ingrid B., Reid, Jeffrey G., Overton, John D., Hansson, Ola, Groop, Leif, Shah, Svati H., Kraus, William E., Rader, Daniel J., Chen, Yii-Der I., Hveem, Kristian, Wareham, Nicholas J., Kathiresan, Sekar, Melander, Olle, Stefansson, Kari, Nordestgaard, Børge G., Tybjærg-Hansen, Anne, Abecasis, Goncalo R., Altshuler, David, Florez, Jose C., Boehnke, Michael, McCarthy, Mark I., Yancopoulos, George D., Carey, David J., Shuldiner, Alan R., Baras, Aris, Dewey, Frederick E., Gromada, Jesper
Published in Nature communications (13.06.2018)
Published in Nature communications (13.06.2018)
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